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Deproteinated calf blood ingredient brain targeting nanosphere and preparation method thereof

A technology for deproteinizing and calf blood, applied in the field of medicine, can solve problems such as difficulty in diagnosing and treating brain diseases, and achieve the effects of easy implementation and simple preparation method.

Inactive Publication Date: 2009-11-18
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most active drugs cannot pass through the blood-brain barrier (BBB), which makes it difficult to diagnose and treat many brain diseases.

Method used

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  • Deproteinated calf blood ingredient brain targeting nanosphere and preparation method thereof
  • Deproteinated calf blood ingredient brain targeting nanosphere and preparation method thereof
  • Deproteinated calf blood ingredient brain targeting nanosphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. Calf Blood Deproteinized Fraction Brain Targeting Nanoparticles

[0020] In parts by weight, the ingredients include: 5 parts of dextran, 30 parts of pluronic F-68, 75 parts of deproteinized calf blood extract injection, 30 parts of n-butyl polycyanoacrylate and 5 parts of Tween 80.

Embodiment 2

[0021] Example 2. Calf blood deproteinized fraction brain-targeted nanoparticles

[0022] In parts by weight, the composition includes: 30 parts of dextran, 5 parts of pluronic F-68, 100 parts of deproteinized calf blood extract injection, 5 parts of n-butyl polycyanoacrylate and 30 parts of Tween 80.

Embodiment 3

[0023] Example 3. Calf Blood Deproteinized Fraction Brain Targeting Nanoparticles

[0024] In parts by weight, the composition includes: 18 parts of dextran, 18 parts of pluronic F-68, 50 parts of deproteinized calf blood extract injection, 18 parts of n-butyl polycyanoacrylate and 18 parts of Tween 80.

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Abstract

The invention discloses a deproteinated calf blood ingredient brain targeting nanosphere preparation method, specifically comprising: according to the parts by weight, dissolving 5-30 parts of stabilizing agent in distilled water, then dissolving 5-30 parts of pluronic F-68 in distilled water, mixing the two obtained solution, shaking well, adding 50-100 parts of deproteinated calf blood extractive injection, shaking well, after constant volume, adjusting the PH value to 1-4, slowly adding 5-30 parts of polybutylcyanoacrylate while stirring; stirring for 1-6h, adjusting PH value to 6-8, stirring for 1-6h to obtain the colloid solution of deproteinated calf blood ingredient nanosphere, filtering, freeze drying; dissolving the freezedrying powder of deproteinated calf blood ingredient nanosphere, adding 5-30 parts of tween 80 and stirring for 0.5-3h to obtain deproteinated calf blood ingredient brain targeting nanophere. The invention has the advantages of simple preparation method, low cost, easy storage, short time to reach the brain, rapid blood clearance rate and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of a nano-preparation of deproteinized calf blood extract of a drug for treating cerebral dementia and cerebral apoplexy. Background technique [0002] The central nervous system (Central nervous system, CNS) incidence rate has been higher than the sum of cancer and cardiovascular diseases, such as brain tumors, Alzheimer's disease, Parkinson's syndrome, viral infection and so on. Because the brain is the center of human central nervous activity and the most complex part of the nervous system. However, most active drugs cannot pass through the blood-brain barrier (BBB), which makes the diagnosis and treatment of many brain diseases difficult. Therefore, solving the problem of drug delivery through the BBB has become the key to the drug treatment of brain diseases. Calf blood deproteinized extract injection is used to treat diseases such as cerebral apoplex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/16A61K9/14A61K9/08A61K47/36A61P25/28A61P7/02A61P9/10A61K35/14
Inventor 楼一层黄芬阮班昭易辉周园
Owner WUHAN UNIV OF TECH
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