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Antibiotic medicament containing amoxicillin nano granule and potassium clavulanate

A technology of potassium clavulanate and amoxicillin is applied in the field of medicine to achieve the effects of improving clinical curative effect, good effect and improving antibacterial activity

Inactive Publication Date: 2008-07-09
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the existing common dosage forms of amoxicillin can no longer meet the clinical treatment requirements, and new preparations with broad-spectrum, high efficiency, sustained release, safety and pathogen targeting must be developed

Method used

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  • Antibiotic medicament containing amoxicillin nano granule and potassium clavulanate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Accurately weigh 0.5g of Dextran T-70 and 0.5g of Poloxamer F68, dissolve them completely with 98.3mL of distilled water, add 200mg of amoxicillin original drug, adjust the pH to 2, add 0.5g of cyanoacrylic acid drop by drop under magnetic stirring n-butyl ester, continue to stir for 5h and then adjust the pH to 6 to obtain a light yellow amoxicillin polycyanoacrylate n-butyl cyanoacrylate nanoparticle colloidal solution, then add clavulanic acid in the ratio of amoxicillin and clavulanate potassium 2:1 Potassium 100mg is mixed, promptly makes the antibiotic medicine solution of the present invention. Finally, the prepared solution is filtered through a 0.45um microporous membrane and then freeze-dried at -40°C to obtain the freeze-dried powder of the present invention. Antibiotic drug solution of the present invention detects through transmission electron microscope and particle size analyzer, and average particle diameter is 128nm, and particle size is uniform, and 85%...

Embodiment 2

[0041] Accurately weigh 1g of Dextran T-70 and 1g of poloxamer F68, dissolve them completely with 96.6mL of distilled water, add 300mg of amoxicillin original drug, adjust the pH to 2.5, add 1g of n-butyl cyanoacrylate drop by drop under magnetic stirring After continuing to stir for 8 hours, adjust the pH to 6.5 to obtain a light yellow amoxicillin polycyanoacrylate n-butyl cyanoacrylate nanoparticle colloidal solution, then add 60 mg of potassium clavulanate in the ratio of amoxicillin to potassium clavulanate 5:1 and mix Evenly, the antibiotic drug solution of the present invention is obtained. Finally, the prepared solution is filtered through a 0.45um microporous membrane and then freeze-dried at -55°C to obtain the freeze-dried powder of the present invention. The antibiotic drug solution of the present invention is detected by a transmission electron microscope and a particle size analyzer, and the average particle size is 137.3nm, and the particle size is uniform, 74% ...

Embodiment 3

[0043] Accurately weigh 2g of Dextran T-70 and 2g of poloxamer F68, dissolve them completely with 93.5mL of distilled water, add 400mg of amoxicillin original drug, adjust the pH to 3, add 2g of n-butyl cyanoacrylate dropwise under magnetic stirring After continuing to stir for 12 hours, the pH was adjusted to be 7 to obtain a light yellow amoxicillin polycyanoacrylate n-butyl cyanoacrylate nanoparticle colloidal solution, and then 40 mg of potassium clavulanate was added and mixed with amoxicillin and potassium clavulanate in a ratio of 10:1. Evenly, the antibiotic drug solution of the present invention is obtained. Finally, the prepared solution is filtered with a 0.45um microporous membrane and then freeze-dried at -70°C to obtain the freeze-dried powder of the present invention. The antibiotic drug solution of the present invention is detected by a transmission electron microscope and a particle size analyzer, and the average particle size is 140.6nm, and the particle size...

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Abstract

The present invention discloses an antibiotic medicine which contains amoxicillin nano-particles and clavulanate potassium and is made from 0.2 percent to 0.4 percent of amoxicillin, 0.02 percent to 0.25 percent of the clavulanate potassium, 0.5 percent to 2 percent of carrier, 0.5 percent to 2 percent of stabilizing agent, 0.5 percent to 2 percent of surfactant and 93 percent to 98.5 percent of distilled water according to the following method that: carrier monomers and the surfactant are dissolved in the distilled water completely; the amoxicillin is added; pH value is adjusted to be 2 to 3; butyl cyanoacrylate is added while being stirred by magnetic force and is stirred continuously for 5 to 12 hours, the pH value is adjusted to be 6 to 7, flaxen amoxicillin poly butyl cyanoacrylate nano-particle colloid solution is obtained; the clavulanate potassium is added by the proportion of the amoxicillin and the clavulanate potassium of 2 ®U 1 to 10 ®U 1 to obtain the antibiotic medicine which not only has simple preparation method but also has the advantages of wide spectrum, high efficiency, being targeted, slow-released, safe, etc.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a broad-spectrum, high-efficiency, sustained-release and safe antibiotic drug containing amoxicillin nanoparticles and potassium clavulanate. technical background [0002] Amoxicillin (Amoxicillin or Amoxycillin), also known as amoxicillin, is a semi-synthetic broad-spectrum acid-resistant aminopenicillin antibiotic. The chemical name of this product is (2S, 5R, 6R)-3,3-dimethyl-6-[(R)-(one)-2-amino-2-(4-hydroxyphenyl)acetamido]-7 -Oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate, molecular formula C 16 h 19 N 3 o 5 S·3H 2 O, the molecular weight is 429.46. [0003] Amoxicillin is an antibiotic commonly used clinically. It has a broad antibacterial spectrum, strong bactericidal power, and rapid action. , Escherichia coli, Salmonella, and Proteus mirabilis are all sensitive, and are widely used clinically to treat sensitive bacterial infections such as the respirator...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K9/19A61K47/16A61K47/32A61P31/04A61K31/424
Inventor 欧阳五庆杨雪峰
Owner NORTHWEST A & F UNIV
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