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Method for preparing magnetic adriamycin poly-alkyl-alfa-cyanoacrylate nanoparticles

A technology of poly(n-butyl cyanoacrylate) and doxorubicin is applied in medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc. Satisfaction and other issues, to achieve the effect of good targeting effect, huge application prospects, and easy implementation

Inactive Publication Date: 2008-10-01
蔡林 +2
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AI Technical Summary

Problems solved by technology

Although there are many treatment methods such as chemotherapy, radiotherapy, surgery, bioregulation therapy, gene therapy, etc., the curative effect is still not satisfactory.
Chemotherapy is one of the main methods to treat tumors, but the severe side effects of chemotherapeutic drugs limit its wide application

Method used

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Examples

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Embodiment Construction

[0007] Describe the present invention in detail below in conjunction with example.

[0008] Fe 3 o 4 Preparation of water-based magnetic fluid: weigh 1.80g of FeCl at a molar ratio of 1.05:2 2 4H 2 O with 4.70 g FeCl 3 ·6H 2 O, dissolved in 85mL of deionized water, then added 10mL of acetone dissolved with 250mg of n-decanoic acid, stirred for 15 minutes to form a homogeneous microemulsion, the stirring speed was 800rpm, then added 10mL of 25% ammonia water dropwise, and then in 5 minutes Add 30ml of acetone dissolved with 2.0g of n-decanoic acid, stir continuously at 80°C to grow the crystal for 30 minutes to form a stable water-based magnetic fluid with a pH value of 5-6, and then cool it slowly to room temperature naturally.

[0009] Preparation of ADM-PBCA-MNPS: Weigh 1.5g of Dextran-70 and dissolve it in 20ml of deionized water, then add 10mg of doxorubicin hydrochloride, stir to dissolve it, then add 1ml of Tween80 solution, and disperse for 10 minutes with ultrasou...

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Abstract

The invention discloses a preparation method of magnetic doxorubicin polybutylcyanoacrylate nanoparticles, which relates to the preparation of osteosarcoma targeted therapeutic nanodrugs. The magnetic doxorubicin polybutylcyanoacrylate nanoparticles are mainly prepared by Fe3O4 water-based magnetic fluid, Dextran-70, Tween80, doxorubicin hydrochloride, Alpha-polybutylcyanoacrylate and so on. The ADM-PBCA-MNPS prepared by the invention is a novel targeted drug delivery system-magnetic targeted drug delivery system, which has the advantages of simple preparation method, lower production cost, good targeted effect, easy implementation of targeted therapy and so on, thus showing great application prospect in the field of the targeted therapy of tumors.

Description

technical field [0001] The invention relates to a preparation method of drug nanoparticles for targeted therapy of osteosarcoma. Background technique [0002] Osteosarcoma is one of the most common malignant tumors of the skeletal system. It occurs frequently in adolescents and has a high degree of malignancy. It is one of the main diseases leading to the death of adolescents. Although there are many treatment methods such as chemotherapy, radiotherapy, surgical treatment, bioregulation therapy, gene therapy, etc., the curative effect is still not satisfactory. Chemotherapy is one of the main ways to treat tumors, but the severe side effects of chemotherapeutic drugs limit its wide application. Therefore, people try to use various drug carriers to construct a targeted drug delivery system for targeted therapy of tumor tissue, which not only enhances the curative effect of chemotherapy drugs but also reduces their toxic and side effects. Therefore, the targeted drug deliver...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/704A61K47/02A61P35/00
Inventor 蔡林胡治平王栋锋
Owner 蔡林
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