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Biomedical material special for human soft tissue adhesion and preparation method thereof

A biomedical material and soft tissue technology, applied in the fields of application, medical science, surgical adhesives, etc., can solve the problems of not being able to meet medical needs to the maximum extent, insufficient bonding strength, bonding speed, and bonding durability, etc., to achieve suitable The effect of large-scale industrial application, cheap raw materials, and improved adhesion durability

Inactive Publication Date: 2016-12-07
胡何辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the usual cyanoacrylate adhesives are more or less deficient in terms of bonding strength, bonding speed, bonding durability, etc., and cannot fully meet medical needs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Weigh 50 parts of n-butyl α-cyanoacrylate, 45 parts of vinylpyrrolidone, 45 parts of hydroxypropyl methacrylate, 40 parts of isopropyl acrylate, 15 parts of acetyl triethyl citrate, aloe 12 parts of nano powder, 10 parts of benzoin dimethyl ether, 8 parts of N,N-dimethyl-p-aniline, 7 parts of trilaurylamine, 5 parts of calcium carbonate, 4 parts of alumina, 4 parts of wollastonite powder, aluminum silicate ceramics 3 parts of fiber, 2 parts of defatted silkworm chrysalis powder, 2 parts of squalane, 1 part of ginkgo biloba extract, 1 part of L-cysteine, 3 parts of carboxymethyl cellulose;

[0025] (2) Mix calcium carbonate, alumina, wollastonite powder, and aluminum silicate ceramic fiber, and add it to a ball mill. The speed of the ball mill is 220 r / min, and the ball is ground into a powder with a particle size of less than 8 μm, and then the mixed powder Put the body into an oven and dry at 120°C to obtain a powdery dry blend;

[0026] (3) Add α-n-butyl cyanoacr...

Embodiment 2

[0031] (1) Weigh 55 parts of n-butyl α-cyanoacrylate, 50 parts of vinylpyrrolidone, 50 parts of hydroxypropyl methacrylate, 45 parts of isopropyl acrylate, 20 parts of tributyl citrate, and aloe nano 14 parts of fine powder, 12 parts of benzoin dimethyl ether, 9 parts of N,N-dimethyl-p-aniline, 8 parts of trilaurylamine, 6 parts of calcium carbonate, 5 parts of alumina, 5 parts of wollastonite powder, aluminum silicate ceramic fiber 4 parts, 3 parts of defatted silkworm chrysalis powder, 3 parts of squalane, 2 parts of ginkgo biloba extract, 2 parts of L-cysteine, 4 parts of sodium gluconate;

[0032] (2) Mix calcium carbonate, alumina, wollastonite powder, and aluminum silicate ceramic fiber, and add it to a ball mill. The speed of the ball mill is 245 r / min, and the ball is ground into a powder with a particle size of less than 8 μm, and then the mixed powder Put the body into an oven and dry it at 135°C to obtain a powdery dry blend;

[0033] (3) Add α-n-butyl cyanoacrylat...

Embodiment 3

[0038] (1) Weigh 60 parts of n-butyl α-cyanoacrylate, 55 parts of vinylpyrrolidone, 55 parts of hydroxypropyl methacrylate, 50 parts of isopropyl acrylate, 25 parts of acetyl tributyl citrate, aloe 16 parts of nano powder, 14 parts of benzoin dimethyl ether, 10 parts of N,N-dimethyl-p-aniline, 9 parts of trilaurylamine, 7 parts of calcium carbonate, 6 parts of alumina, 6 parts of wollastonite powder, aluminum silicate ceramics 5 parts of fiber, 4 parts of defatted silkworm chrysalis powder, 4 parts of squalane, 3 parts of ginkgo biloba extract, 3 parts of L-cysteine, 5 parts of zinc oxide;

[0039] (2) Mix calcium carbonate, alumina, wollastonite powder, and aluminum silicate ceramic fiber, and add it to a ball mill. The speed of the ball mill is 270 r / min, and the ball is ground into a powder with a particle size of less than 8 μm, and then the mixed powder Put the body into an oven and dry it at 150°C to obtain a powdery dry blend;

[0040] (3) Add α-n-butyl cyanoacrylate, ...

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PUM

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Abstract

The invention discloses a biomedical material special for human soft tissue adhesion. Alpha-butylcyanoacrylate, vinylpyrrolidone, hydroxypropyl methacrylate and isopropyl acrylate serve as the main components, citrate, aloe nano powder, benzil dimethyl ketal, N,N-dimethyl aniline, trilaurylamine, calcium carbonate, aluminum oxide, wollastonite powder, alumina-silicate ceramic fiber, degreased pupa powder, squalane, folium ginkgo extracts, L-cysteine and retarder are added, ball-milling, ultrasonic dispersing, mixing and stirring, drying, irradiation sterilizing and other processes are adopted, and therefore the adhesion strength, adhesion speed, adhesion durability and other aspects of the prepared biomedical material special for human soft tissue adhesion are remarkably improved, the industry requirements can be met, and the material has good application prospects.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a special biomedical material for bonding human soft tissues and a preparation method thereof. Background technique [0002] With the advancement of medicine, the clinical requirements for the effect of surgical techniques and auxiliary materials are getting higher and higher. The philosophy of modern medicine is to minimize the pain of the patient, to allow the patient to recover as quickly as possible, and to restore the function to the greatest extent while also restoring the appearance perfectly. Therefore, the continuous increase of clinical demand has promoted the development of medical adhesive research and the clinical application of adhesive technology. [0003] Medical adhesive is a branch of medical polymer. It takes biological tissue as the bonding object. Most of the tissues and organs of the human body can be replaced by adhesive technology during the treatmen...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/00
CPCA61L24/02A61L24/0005A61L24/001
Inventor 胡何辉
Owner 胡何辉
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