397results about How to "Fast aggregation" patented technology

The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which can be utilized to generate a high protein concentration liquid suitable for administration to a subject. The invention further provides methods of utilizing the formulations of the present invention for therapeutic or prophylactic treatment of diseases and disorders or for diagnostic purposes.

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

A method and data structure is described that builds summary information using processor time that is usually proportional to the size of input data and a depth of hierarchies for a plurality of attributes. The output of computation is stored in a smaller area by eliminating redundant storage and computation. An index is generated which includes tuples or rows that include lower bound values for each of the attributes, values of children of the lower bound values based on the hierarchies of the attributes, and coverage class indicators of the coverage classes of the children.

The present invention relates to a curing assembly comprising at least two light sources combined into one light path, wherein the light sources are capable of curing a material exposed to the combined light path. The invention also relates to a method of curing a material or material in contact with a heat sensitive material comprising providing a curable material or a material associated with a heat sensitive material and exposing curable material to a combined light path from the curing assembly.

A method of collecting and authenticating electronic thereby, including the steps of storing a representation of a first handwritten signature and an associated first of a first signatory in a database, storing a representation of a second handwritten signature and an associated second authenticated electronic signature of a second signatory in the database, creating a message digest for a document file associated with a document to be signed, appending the message digest to the document file, transmitting the document file with the appended message digest to the first and second signatories, receiving the document file with the appended message digest from the first and second signatories after the first and second signatories electronic signatures, respectively, to the document rile, and, authenticating the first and second signatures, respectively, and the electronically signed document file. An apparatus for implementing the method is also disclosed.

The present invention relates to a curing assembly comprising at least two light sources combined into one light path, wherein the light sources are capable of curing a material exposed to the combined light path. The invention also relates to a method of curing a material or material in contact with a heat sensitive material comprising providing a curable material or a material associated with a heat sensitive material and exposing curable material to a combined light path from the curing assembly.

A multi-function vacuum bag for use in the manufacture of composites, wherein the vacuum bag may be configured to provide all-in-one capabilities, namely to function as the vacuum bag, a caul or caul sheet, release layer and / or a breather, as well as to provide other functions. Specifically, the multi-function vacuum bag allows a separate breather or breather material, a separate caul or caul layer, and a release or release layer all to be eliminated, if desired, as the multi-function vacuum bag is capable of performing the functions of each of these once formed. Furthermore, the multi-function vacuum bag may be used with various composite manufacturing process, such as VARTM or resin infusion processes, various vacuum bagging processes, filament winding processes, and others.

The present invention discloses a new class of triarylsulfonium salt photoacid generators (PAGs), which are thermally stable and can be activated by long wavelength UV or visible light. The sulfonium PAGs of the present invention are additionally soluble in monomers that can be polymerized by cationic polymerization chemistry, and mixtures of said sulfonium PAGs and monomers can be stored for long periods of time without undergoing polymerization. Furthermore, typical holographic recording media comprising one of these sulfonium PAGs, polymerizable monomer(s), a sensitizing dye, and a binder can be stored for long periods of time without exhibiting significant loss of recording sensitivity. Preferred sulfonium PAGs of the present invention are sulfonium PAGs substituted with one or more fluoro or fluoroalkyl groups.

The invention discloses a fluorine-contained surfactant and a preparation method thereof. The fluorine-contained surfactant is characterized in that a fluorine-contained monomer and a non fluorine-contained monomer, such as acrylic ester are processed by an anion polymerization technology to obtain a segmented copolymer. Compared with the prior art, the fluorine-contained surfactant has a segmented structure, has the advantages of excellent surface activity, pure product, low polymerization temperature, high polymerization speed, wide application prospect and excellent efficacy in the field of leveling; and no active groups or catalysts are introduced in.

The invention relates to a preparation method for cationic-type polyacrylamide reverse micro emulsion. The appearance of the micro emulsion is transparent or translucent low-viscosity micro latex and the mean particle diameter is 50 to 80 nm. The micro emulsion can be placed for a long time without delaminating. After routine extraction with alcohol and acetone, the micro emulsion becomes white powdered solids with the intrinsic viscosity of 200-600 ml / g. The preparation method is to take acrylamide and diallyl dimethyl ammonium chloride as comonomer, apply compounded emulsifying agent and redox initiation system, add sodium formate as reagent and additive in polymerization, and then apply the method of stepwise polymerization to the reverse micro emulsion polymerization. The cationic-type polyacrylamide of the invention has the advantages of moderate molecular weight, stable emulsion, rapid dissolution and narrow particle size distribution, thus being able to be widely applied to fields such as oil exploitation, paper making, textile dying, daily chemical industry and industrial water treatment.

A radiation polymerisable composition comprising: (A) a donor / acceptor component for forming a charge transfer complex said component being selected from the group consisting of: (i) a bifunctional compound having an electron donor group and an electron withdrawing group and a polymerisable unsaturated group; (ii) a mixture of (a) at least one unsaturated compound having an electron donor group and a polymerisable unsaturated moiety; and (b) at least one unsaturated compound having an electron acceptor group and a polymerisable unsaturated group; and (B) a Lewis acid.

The invention discloses an ultra-thin polyester double-sided adhesive tape comprising a polyester thin film layer and two glue layers formed by glue coated on front and back sides of the polyester thin film. The thickness of the polyester thin film is 0.001-0.0012mm. The thickness of the glue layer is 0.002mm. Therefore, the thickness of the double-sided adhesive tape is only 0.005mm, such that electronic product development trends of thin and light can be satisfied. The total thickness of adhesive is 0.004mm, such that the tape has ultra-low thermal resistance, and heat generated by electrical components can be conducted in time. Therefore, electrical component damage caused by long-term working under high temperature is avoided. Also, the invention discloses a formula for the glue used in the ultra-thin polyester double-sided adhesive tape. The glue comprises the raw materials of, by weight, 100 parts of acrylate prepolymer resin, 0.5-3 parts of a curing agent, and 100-200 parts of ethyl acetate. With the glue, a single side thickness is 0.002mm, and high adhesive performance can be provided.

A digital interface between analogue RF hardware and digital processing hardware which (a) defines how the analogue RF hardware and digital processing hardware send and receive digital data to one another and (b) is open in order to decouple the design of the analogue RF hardware from the design of the digital processing hardware. The adoption of such an interface will facilitate the uptake of software defined radio (SDR), both as a design-time and run-time technology, as it enables the production of analogue / RF components independently from the digital domain hardware and software.

Disclosed is a presensitized plate composed of a support having thereon an image recording layer which includes: an infrared absorber (A) that is a cyanine dye having at least one fused ring composed of a nitrogen-containing heterocycle in combination with an aromatic ring or a second heterocycle, and having on the aromatic ring or second heterocycle an electron-withdrawing group or a heavy atom-containing group, a radical generator (B), and a radical-polymerizable compound (C), and which is removable with printing ink and / or dampening water. The presensitized of the present invention can be imaged with an infrared light-emitting laser to directly record an image from digital data on a computer or the like and is then subjected to on-machine development without carrying out a development step, which is capable of providing a large number of good impressions with a practical amount of energy.

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

An active energy ray curable ink which is quickly polymerized by an active energy ray, high in crosslinking degree of a cured material formed, excellent in adhesive property, low in viscosity, excellent in long-term storability and also excellent in ejection stability, and an ink-jet recording process, an ink cartridge, a recording unit and an ink-jet recording apparatus using such an ink are provided. In the active energy ray curable aqueous ink comprising at least water and a polymerizable material which is radically polymerized by an active energy ray, the polymerizable material is a water-soluble polymerizable material represented by the following general formula (I). An ink-jet recording process, an ink cartridge, a recording unit and an ink-jet recording apparatus using such an ink

A polymerizable composition contains (A) a dye which is soluble in an organic solvent and in an alkaline aqueous solution and has an absorption in 700 to 1200 nm, (B) a radical polymerization initiator, (C) a compound having an ethylenically unsaturated bond, and (D) a binder polymer.

The invention relates to a pigment dispersion method, a pigment mixture, light-cured ink and thermo-cured ink. The pigment dispersion method comprises the steps of: mixing 0.05-20wt% of dispersion resin and 5-10wt% of solvent in a stirring way, and preparing dispersion resin solution; mixing 1-20wt% of dispersing agent and 15-20wt% of solvent in a stirring way, and preparing dispersing agent solution; adding 5-20wt% of pigment to be dispersed into the dispersing agent solution, and preparing first mixed solution; adding the dispersion resin solution into the first mixed solution, and preparing second mixed solution; adopting 20-55wt% of solvent to dilute the second mixed solution; and using a sand mill to grind and disperse the second mixed solution which is evenly diluted. The invention has the advantages of small grain diameter, narrow range of grain fineness distribution, low viscosity, excellent wettability, high storage stability and the like.

There is provided a recording ink containing at least: water; a water-soluble organic solvent; a surfactant; and a carbon black having a hydrophilic group on a surface thereof, wherein the carbon black releases humic acid in an aqueous dispersion of the carbon black, which is recovered from the recording ink, a concentration of the humic acid released in the aqueous dispersion containing 20% by mass of the carbon black of is expressed with a maximum absorbance at a wavelength of 230 nm to 260 nm, and the recording ink has the maximum absorbance of 5.0 to 20.0 at the wavelength of 230 nm to 260 nm.

An acrylamide derivative of the following general formula (I) is used to prepare a polymer or copolymer:wherein R1 represents a hydrogen atom, a straight-chain or branched alkyl group containing 1 to 4 carbon atoms or a C3-6 cycloalkyl group, R2 and R3 each independently represent an alkylene group containing 1 to 6 carbon atoms or R2 and R3 may be combined to form a ring, X represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group, and Y represents an amino group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group. The thus obtained polymer or copolymer is a polymer or hydrogel incorporating many functional groups while maintaining the sensitive temperature response.

The invention provides a software development method and device based on crowdsourcing. The method comprises the following steps: receiving original software requirements input by a demand provider; distributing the original software requirements to a product manager to enable the product manager to generate and publish a PRD (Product Requirement Document) according to the original software requirements; generating a first MDT (Module Development Task) corresponding to the PRD; distributing the first MDT to a product architect to enable the product architect to generate a plurality of second MDTs according to the first MDT and publish the plurality of second MDTs to internet users; receiving at least one group of deliverable products submitted by the internet users, and distributing the at least one group of deliverable products to the product architect to enable the product architect to generate a software product corresponding to the original software requirements according to the at least one group of deliverable products. According to the method, large-scale concurrence development can be realized, and software development speed is greatly improved.

A dual catalyst system thermoplastic phenolic resin preparation method comprises the steps of proportioning, refluxing and reacting, and drying; the raw materials comprises phenol or m-cresol and aldehydes compound, water, organic acid or inorganic acid and bivalent acetate in a molar ratio of 1:0.5-0.9:0-3.0:0.001-0.040:0.001-0.020; wherein, acetate is used as first catalyst and organic acid or inorganic acid is used as second catalyst in reaction process. The invention adopts phenolic aldehyde addition-condensation reaction in dual catalyst system to prepare the thermoplastic phenolic resin; the method has the advantage of rapid polymerization rate, high yield and low content of free phenols; the thermoplastic phenolic resin can be applied for preparing the coated sand and the prepared coated sand has higher hot tensile strength and tensile strength at room temperature.

The present invention provides polymeric quaternary ammonium photoinitiators being co-polymers of photoinitiator monomers, as well as quaternary ammonium photoinitiator monomer being valuable intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided a polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a quaternary ammonium are incorporated into the photoinitiator structure.

An arcless, atmospheric-pressure plasma generating apparatus capable of producing a large-area, temperature-controlled, stable discharge at power densities between about 0.1 W / cm3 and about 200 W / cm3, while having an operating gas temperature of less than 50° C., for processing materials outside of the discharge, is described. The apparatus produces active chemical species, including gaseous metastables and radicals which may be used for polymerization (either free radical-induced or through dehydrogenation-based polymerization), surface cleaning and modification, etching, adhesion promotion, and sterilization, as examples. The invention may include either a cooled rf-driven electrode or a cooled ground electrode, or two cooled electrodes, wherein active components of the plasma may be directed out of the plasma and onto an external workpiece without simultaneously exposing a material to the electrical influence or ionic components of the plasma.

Disclosed are a paper-plastic glue and its preparing method,comprising of high polymer latex 70-90%,resin 5-15%,inorganic powder filler 3-15%,dispersant 0.5-0.8%,thickener 0.2-0.5% and deformer 0.1-0.3%. Its preparing method is:1.pre the deformer with high polymer latex; 2. disperse; 3. add into inorganic filler and disperse;4.add into resin and disperse;5. add into thickener for adjusting the viscosity to be the construction one,the output and package the material.

A method of collecting and authenticating electronic signatures and documents signed thereby, including the steps of storing a representation of a first handwritten signature and an associated first authenticated electronic signature of a first signatory in a database, storing a representation of a second handwritten signature and an associated second authenticated electronic signature of a second signatory in the database, creating a message digest for a document file associated with a document to be signed, appending the message digest to the document file, transmitting the document file with the appended message digest to the first and second signatories, receiving the document file with the appended message digest from the first and second signatories after the first and second signatories have affixed their first and second electronic signatures, respectively, to the document file, and, authenticating the first and second signatures, respectively, and the electronically signed document file. An apparatus for implementing the method is also disclosed.

A spray-type staltic adhesive is prepared from the alpha-n-octyl cynoacrylate (1-50 wt.%) and the alpha-n-butyl cynoacrylate (1-80 wt.%) through proportioning, sequentially loading them in a container, stirring for 30-80 min, filtering by 0.45-micron medical film, and biological testing to be negative. Its advantages are high polymerizing speed, adhesion and diffusivity, less intradermal reaction, and high safety. It can be used in human body.