397results about How to "Fast aggregation" patented technology

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

The present invention relates to a silicone (meth)acrylamide monomer, and this silicone (meth)acrylamide monomer is particularly suitable for use in contact lenses, intraocular lenses, artificial cornea, and the like.

An arcless, atmospheric-pressure plasma generating apparatus capable of producing a large-area, temperature-controlled, stable discharge at power densities between about 0.1 W / cm3 and about 200 W / cm3, while having an operating gas temperature of less than 50° C., for processing materials outside of the discharge, is described. The apparatus produces active chemical species, including gaseous metastables and radicals which may be used for polymerization (either free radical-induced or through dehydrogenation-based polymerization), surface cleaning and modification, etching, adhesion promotion, and sterilization, as examples. The invention may include either a cooled rf-driven electrode or a cooled ground electrode, or two cooled electrodes, wherein active components of the plasma may be directed out of the plasma and onto an external workpiece without simultaneously exposing a material to the electrical influence or ionic components of the plasma.

A method of collecting and authenticating electronic signatures and documents signed thereby, including the steps of storing a representation of a first handwritten signature and an associated first authenticated electronic signature of a first signatory in a database, storing a representation of a second handwritten signature and an associated second authenticated electronic signature of a second signatory in the database, creating a message digest for a document file associated with a document to be signed, appending the message digest to the document file, transmitting the document file with the appended message digest to the first and second signatories, receiving the document file with the appended message digest from the first and second signatories after the first and second signatories have affixed their first and second electronic signatures, respectively, to the document file, and, authenticating the first and second signatures, respectively, and the electronically signed document file. An apparatus for implementing the method is also disclosed.