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Sustained-release formulation of nano-zinc green tea coated with n-butyl cyanoacrylate and its application

A technology of n-butyl cyanoacrylate and slow-release preparations, which is applied in the field of sustained-release preparations of nano-zinc green tea wrapped in n-butyl cyanoacrylate, to achieve the effects of improving bioavailability, increasing solubility, and enhancing stability

Active Publication Date: 2021-07-16
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Yet so far, there is no report that polycyanoacrylate n-butyl cyanoacrylate and green tea are jointly used in zinc supplementation

Method used

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  • Sustained-release formulation of nano-zinc green tea coated with n-butyl cyanoacrylate and its application
  • Sustained-release formulation of nano-zinc green tea coated with n-butyl cyanoacrylate and its application
  • Sustained-release formulation of nano-zinc green tea coated with n-butyl cyanoacrylate and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of nano-zinc green tea sustained-release preparation coated with n-butyl cyanoacrylate

[0049] (1) Preparation of Nano Zinc Green Tea

[0050] Grind the green tea leaves, weigh 10g of green tea powder and put it into 200mL of ultrapure water, stir it magnetically at 1000r / min for 1h, then pass it through 8μm grade filter paper and 220nm grade filter membrane to obtain the green tea extract, then add 0.10 The mol / L zinc acetate ultrapure aqueous solution is dripped dropwise into the green tea extract that is being continuously stirred (1000r / min) with a volume ratio of 1:1. liquid, the nano-zinc green tea crude liquid is centrifuged 3 times, and the obtained solids are dispersed in ultrapure water for freezing and freeze-drying to obtain a nano-zinc green tea freeze-dried powder;

[0051] (2) Preparation of poly(n-butyl cyanoacrylate) coated nano-zinc green tea sustained-release preparation

[0052] Prepare the organic phase mixture: disperse 3.0 mg of nan...

Embodiment 2

[0065] Preparation of nano-zinc green tea sustained-release preparation coated with n-butyl cyanoacrylate

[0066] (1) Preparation of Nano Zinc Green Tea

[0067] Grind the green tea leaves, weigh 10g of green tea powder and put it into 100mL of ultrapure water, stir magnetically at 1000r / min for 2h, then pass through 5μm grade filter paper and 220nm grade filter membrane for vacuum filtration to obtain green tea extract, and then add 0.10 The mol / L zinc acetate ultrapure aqueous solution is dripped dropwise into the green tea extract that is being continuously stirred (1000r / min) with a volume ratio of 1:1. liquid, the nano-zinc green tea crude liquid is centrifuged 3 times, and the obtained solids are dispersed in ultrapure water for freezing and freeze-drying to obtain a nano-zinc green tea freeze-dried powder;

[0068] (2) Preparation of poly(n-butyl cyanoacrylate) coated nano-zinc green tea sustained-release preparation

[0069] Prepare the organic phase mixture: disper...

Embodiment 3

[0076] Preparation of nano-zinc green tea sustained-release preparation coated with n-butyl cyanoacrylate

[0077] (1) Preparation of Nano Zinc Green Tea

[0078] Grind the green tea leaves, weigh 10g of green tea powder and put it into 100mL of ultrapure water, stir magnetically at 1000r / min for 1h, then pass through 6μm grade filter paper and 220nm grade filter membrane for vacuum filtration to obtain green tea extract, and then add 0.10 The mol / L zinc acetate ultrapure aqueous solution is dripped dropwise into the green tea extract that is being continuously stirred (1000r / min) at a volume ratio of 1:2. After biosynthesis reaction at room temperature for 2 hours, the obtained nano-zinc green tea The crude liquid is centrifuged three times with the nano-zinc green tea crude liquid, and the obtained solids are dispersed in ultrapure water for freezing and freeze-drying to obtain the nano-zinc green tea freeze-dried powder;

[0079] (2) Preparation of poly(n-butyl cyanoacryla...

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Abstract

The invention discloses a nano-zinc green tea slow-release preparation coated with n-butyl polycyanoacrylate, which comprises n-butyl polycyanoacrylate nanoparticles and nano-zinc green tea loaded in the n-butyl polycyanoacrylate nanoparticles. The present invention utilizes green tea extract and Zn under normal temperature 2+ It is easy to chelate the chemical reactivity and spontaneous polymerization of n-butyl cyanoacrylate in water, use green biosynthesis method to synthesize nano-zinc green tea, and use nano-zinc green tea as medicine to adopt two-phase interface spontaneous polymerization method A polycyanoacrylate-coated nano-zinc green tea sustained-release preparation was prepared. The slow-release time is as long as 72 hours, and it has the advantages of good biocompatibility, good biodegradability, and low toxicity.

Description

technical field [0001] The invention relates to the field of zinc supplements, in particular to a sustained-release preparation of nano-zinc green tea coated with n-butyl cyanoacrylate and its application. Background technique [0002] Zinc is an essential micronutrient element for mammals. It can be used as a coenzyme of metalloenzymes to regulate body metabolism and produce important biological effects, such as increasing growth rate, improving appetite, treating dermatitis, pica, etc. It has also been reported to regulate cell proliferation and growth to prevent the development and progression of prostate or other cancers. It is estimated that 17% of the world's population in 2011 and 31% in 2014 suffer from zinc deficiency, as can be seen with the reduction in the proportion of animal foods in the diet, and the presence of phytic acid, which inhibits zinc absorption in major food sources, can be observed Zinc deficiency has shown an increasing trend year by year. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K36/82A61K47/32A61P3/02A61K33/30
CPCA61K9/5138A61K33/30A61K36/82A61P3/02A61K2300/00
Inventor 鲍官虎姚京京
Owner ANHUI AGRICULTURAL UNIVERSITY
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