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Cyanoacrylate medical adhesive and preparation method thereof

A technology of cyanoacrylate and n-butyl cyanoacrylate is applied in the fields of high-performance tissue adhesives, cyanoacrylate medical adhesives and their preparation, and achieves strong bactericidal properties, fast bonding speed and strong adhesion. combined effect

Inactive Publication Date: 2021-11-05
NANJING SHUANGWEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A good tissue adhesive must have good biocompatibility, good bonding strength and durability, certain elasticity and toughness, non-toxic, and can be used in normal temperature, normal pressure, and humid environments, etc., while Most tissue adhesives made of other raw materials cannot meet the above requirements

Method used

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  • Cyanoacrylate medical adhesive and preparation method thereof
  • Cyanoacrylate medical adhesive and preparation method thereof
  • Cyanoacrylate medical adhesive and preparation method thereof

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preparation example Construction

[0052] Further, a preparation method of cyanoacrylate medical adhesive, the specific preparation steps are as follows:

[0053] (1) Dissolution of basic raw materials:

[0054] Weigh each component by mass ratio;

[0055] First, divide α-n-butyl cyanoacrylate into 3 equal parts, take one of them, and add it to the reactor;

[0056] Then, add weighed tributyl citrate, hydroxypropyl methacrylate, sebacate, tannic acid and thickener to the reactor in order; stir at room temperature and at a constant stirring rate , until it dissolves and disperses, and then save it for later use;

[0057] (2) Dissolution of stabilizers and colorants:

[0058] Get one of the remaining two equal parts of n-butyl cyanoacrylate, add it to another reactor, then add a weighed stabilizer, stir at room temperature and at a constant stirring rate until it reaches dissolve;

[0059] Then add the weighed coloring agent, and stir at room temperature and at a constant stirring rate until it dissolves, an...

Embodiment 1

[0067] Accurately weigh 100 parts of n-butyl α-cyanoacrylate (reference material), 5 parts of tributyl citrate, 1 part of hydroxypropyl methacrylate, 3.6 parts of sebacate, (stabilizer) to 0.3 part of quinone, 0.5 part of tannic acid, 1 part of polybutylcyanoacrylate (thickener), 0.005 part of D&C purple dye No. 2 (colorant) and fully stirred to prepare cyanoacrylate medical glue, And use it for 180-degree tensile strength test and curing test; the results show that its adhesive strength is about 170kpa, and the curing time is about 17s.

Embodiment 2

[0069] Accurately weigh 100 parts of n-butyl α-cyanoacrylate (reference material), 5 parts of tributyl citrate, 7 parts of hydroxypropyl methacrylate, 3.6 parts of sebacate, (stabilizer) to 0.08 part of methoxyphenol, 0.05 part of p-toluenesulfonic acid, 1.5 part of tannic acid, 5 parts of (thickener) polylactic acid, 0.005 part of colorant and fully stirred to prepare cyanoacrylate medical glue, and carried out 180 Tensile strength test and curing test; the results show that the bonding strength is 160kpa, and the curing time is about 10s.

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Abstract

The invention discloses a cyanoacrylate medical adhesive and a preparation method thereof, and belongs to the field of biomedical materials. The cyanoacrylate medical adhesive comprises the following components in percentage by mass of 100 parts of alpha-n-butyl cyanoacrylate, 2-8 parts of tributyl citrate, 1-7 parts of hydroxypropyl methacrylate,1-5 parts of sebacate, 0.05-3 parts of a stabilizer, 0.5-2.5 parts of tannic acid, 1-5 parts of a thickening agent, and 0.001-0.05 part of a coloring agent; and the preparation method comprises the following steps of weighing alpha-n-butyl cyanoacrylate, tributyl citrate, hydroxypropyl methacrylate, sebacate, the stabilizer, tannic acid, the thickening agent and the coloring agent according to a mass ratio to prepare the cyanoacrylate tissue adhesive. The cyanoacrylate medical tissue adhesive prepared by the invention takes the alpha-cyanoacrylate alkyl ester as a main component; and due to high reaction activity, the prepared cyanoacrylate medical adhesive has the advantages of strong bactericidal activity, strong adhesive force, high bonding speed and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a high-performance tissue adhesive mixed with several materials; in particular, it relates to a cyanoacrylate medical adhesive and a preparation method thereof. Background technique [0002] Although technological advances have enabled rapid developments in medical technology and resulted in novel surgical techniques, traditional mechanical closure techniques for tissue anastomosis and wound repair have remained unchanged. Suturing is always imperfect for clinicians and patients, it is time-consuming, prolongs the procedure time, and increases the risk of infection. Relatively speaking, tissue adhesives are a promising medical material for hemostasis, wound closure, tissue repair, and implant fixation. A good tissue adhesive must have good biocompatibility, good bonding strength and durability, certain elasticity and toughness, non-toxic, and can be used in normal temperature, ...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00A61L24/04
Inventor 秦梦娇游虎飞何琴玲潘维超乔梦娜
Owner NANJING SHUANGWEI BIOTECH
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