A kind of antibacterial rapid hemostasis medical glue material and preparation method thereof

A fast, propolis-based technology, applied in pharmaceutical formulations, applications, medical science, etc., can solve problems such as poor hemostatic performance

Active Publication Date: 2022-06-21
FUALIE SCI & TECH DEVING BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is to provide an antibacterial type rapid hemostasis medical adhesive material, to solve the problem of poor hemostatic performance of the simple cyanoacrylic medical adhesive material in the prior art;

Method used

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  • A kind of antibacterial rapid hemostasis medical glue material and preparation method thereof
  • A kind of antibacterial rapid hemostasis medical glue material and preparation method thereof
  • A kind of antibacterial rapid hemostasis medical glue material and preparation method thereof

Examples

Experimental program
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Effect test

preparation example 1

[0024] Preparation Example 1 Preparation of n-butyl cyanoacrylate

[0025] This preparation example is used to prepare the required n-butyl cyanoacrylate, and specifically includes the following steps:

[0026] (1) butyl ester transesterification reaction

[0027] CNCH 2 COOC 2 H 5 +C 4 H 9 OH—C 2 H 5 ONa→CNCH 2 COOC 4 H 9 +C 2 H 5 OH

[0028] In a 5L three-neck beaker equipped with a stirrer and a thermometer, put in 1400ml of ethyl cyanoacetate and 1200ml of n-butanol, turn on stirring, condense water, heat up to 40 degrees and above and add 25g of sodium ethoxide; At -82°C, ethanol began to distill. When the internal temperature reached 110°C and the top temperature reached 98-100°C, the heating was stopped and about 680ml of ethanol was collected;

[0029] Cool down to about 50°C inside temperature, turn on heating, change the bottle with vacuum pump to receive n-butanol, the vacuum degree is -0.1MPa, when the inner temperature rises to about 95°C and the top...

preparation example 2

[0039] Preparation Example 2 Preparation of n-octyl cyanoacrylate

[0040] This preparation example is used to prepare the required n-octyl cyanoacrylate, which specifically includes the following steps:

[0041] (1) with step (1) in Preparation Example 1;

[0042] (2) with step (2) in Preparation Example 1;

[0043] (3) Synthesis of n-octyl α-cyanoacrylate

[0044]

[0045]Add 380ml of methanol-formaldehyde solution and 0.95ml of piperidine to a 5L three-necked flask equipped with a stirrer, dropping funnel, condenser and water separator. When the temperature in the flask reaches 40°C and above, start to add cyanoacetic acid dropwise. 750ml of octyl ester, after the dropwise addition, collect methanol until the internal temperature is 120℃; then add 300ml of petroleum ether dropwise, start dehydration, speed up stirring, when the ether water layer in the reflux separator is clarified, the actual water is about 16ml, and the After the water is finished, about 300ml of pe...

Embodiment 1

[0050] The preparation method of the medical glue material for rapid hemostasis described in this embodiment includes the following steps:

[0051] (1) according to the mass ratio of 55wt%:45wt%, get the above-mentioned n-butyl cyanoacrylate and n-octyl cyanoacrylate and fully mix to obtain the required α-cyanoacrylate mixture; According to 70wt%: The mass ratio of 30wt% is fully mixed with the above-mentioned α-cyanoacrylate mixture and propolis to obtain the required medical glue matrix, for subsequent use;

[0052] (2) take carboxymethyl chitosan and place it with 1-methylimidazolium trifluoroacetate ionic liquid (accounting for 8wt% of the carboxymethyl chitosan quality) and cactus juice (directly squeezed with cactus) Obtain the juice, accounting for 5wt% of the carboxymethyl chitosan mass) in a closed container, remove the air and fill the container with CO 2 , control the temperature in the airtight container to 80°C and the pressure to 8MPa, so that the charged CO 2 ...

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Abstract

The invention belongs to the technical field of biomedical materials, in particular to an antibacterial medical adhesive material for quick hemostasis, and further discloses a preparation method thereof. The medical adhesive material of the present invention uses α-n-butyl cyanoacrylate and α-n-octyl cyanoacrylate as a mixed medical adhesive matrix, and is mixed with CO 2 The method of swelling and modifying the hemostatic material carboxymethyl chitosan with the selected ionic liquid and antibacterial agent carried by the supercritical fluid not only effectively improves the hemostatic performance of carboxymethyl chitosan, but also makes the whole medical adhesive material hemostatic The performance is greatly improved, and rapid hemostasis is realized, and the medical glue has better antibacterial performance, and can be applied to more clinical occasions.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to an antibacterial type rapid hemostatic medical glue material, and further discloses a preparation method thereof. Background technique [0002] Medical adhesives refer to preparations, materials or substances that can be adhered to or bonded between surfaces and are used in medical applications. They belong to special biomedical functional adhesives and are mainly used for local adhesion and repair of organs or tissues. Traditional suturing, or the combination and positioning of tissue and blood vessels for sealing and other technical fields, not only has the usual gluing function and mechanical function, but also has biomedical functions. Compared with traditional methods such as suturing and stapling, the use of medical glue can effectively shorten the operation time and significantly reduce the pain of patients. It is currently the preferred material for medical o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00C08F220/34C08B37/08
CPCA61L24/08A61L24/0015C08F220/34C08B37/003A61L2400/04A61L2300/404A61L2300/236C08L5/08Y02P20/54
Inventor 王威田霞张俊杰张怡婷王占光梁永菡刘冲田素
Owner FUALIE SCI & TECH DEVING BEIJING
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