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Quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and preparation method of quercetin nano sustained-release preparation

A nano-sustained-release, quercetin technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, nanotechnology and other directions, can solve the problem of unsatisfactory disease treatment effect, high preparation process requirements and complex and other problems, to achieve the effect of promoting penetration and absorption time, enhancing oral absorption, and enhancing stability.

Pending Publication Date: 2022-01-04
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these preparations can improve the water solubility and bioavailability of quercetin, the therapeutic effect on diseases is not very ideal, and the preparations also have certain toxicity, and the preparation process requires high and complicated deficiencies.

Method used

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  • Quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and preparation method of quercetin nano sustained-release preparation
  • Quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and preparation method of quercetin nano sustained-release preparation
  • Quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and preparation method of quercetin nano sustained-release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Method for preparing a safe and effective quercetin nano sustaining preparation for anti-silicone fibrosis

[0033] Step 1: 0.04 g of frozine is completely dissolved in 1 ml of glacial acetic acid, gradually slowly add water and adds an appropriate amount of glacial acetic acid to adjust the pH to 3.3, and make the mixed end volume of 80 ml.

[0034] Step 2: 0.10 grams of dodecyl sodium sulfate and 0.8 Cosol Sham-68 were added to a solution obtained in the above steps and ultrasonically 5 minutes to make a mixed uniform solution.

[0035] Step 3: Under the continuous magnetic force of 1100R / min, 200 μ-cyanoacrylate solution is slowly added to the stirring mixing medium in the above step 2. After 2.5 hours of the stirring rate at room temperature, the pH to 7.0 was adjusted with 0.01 mol / L of sodium hydroxide, and the quercetin drumped into the nano-suspension of the p-cyanoacrylate.

[0036] Step 4: 1.1 grams of the right-referenced anhydride-70 is dissolved in 20 ml of...

Embodiment 2

[0050] Method for preparing a safe and effective quercetin nano sustaining preparation for anti-silicone fibrosis

[0051] The preparation method includes the following steps:

[0052] Step 1: 0.06 g of falsecein is completely dissolved in 1 ml of glacial acetic acid, gradually slowly add water and adds an appropriate amount of ice acetic acid to adjust the pH to 3.1 and make the mixed end volume of 80 ml.

[0053] Step 2: 0.08 g of dodecyl sodium sulfate and 0.7 Cosol Sham-68 were added to the above-mentioned steps and uniform solutions were mixed in a solution obtained.

[0054] Step 3: Under the continuous magnetic force of 1000R / min, the 180 μl α-cyanoacrylate solution is slowly added to the stirring mix medium in the above step II. After 2.0 hours of the stirring rate at room temperature, the pH to 7.0 was adjusted with 0.01 mol / L of sodium hydroxide, and the nano-suspension of the quercetin inlet cyanoacrylate was initially obtained.

[0055] Step 4: The 20 ml of aqueous...

Embodiment 3

[0058] Method for preparing a safe and effective quercetin nano sustaining preparation for anti-silicone fibrosis

[0059] The preparation method includes the following steps:

[0060] Step one: 0.08 g quercetin completely dissolved in 1 ml of glacial acetic acid, and water was added slowly and gradually add an appropriate amount of glacial acetic acid such that the pH was adjusted to 2.9 and final volume of 80 ml mixing.

[0061] Step 2: 0.06 g sodium lauryl sulfate and 0.6 g poloxamer -68 was added to the resultant solution and a step for 3 minutes into a mixed solution of ultrasound.

[0062] Step Three: continuous magnetic stirring at 950r / min, the solution was stirred, n-butyl acrylate, 160 microliters of α- cyano slowly dropwise added to the above two steps in the mixed media. Stirring rate were maintained 1.8 hours at room temperature, with sodium hydroxide 0.01mol L / pH adjusted to 7.0, the carrier may be initially obtained into Quercetin n-butyl cyanoacrylate nanosuspens...

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Abstract

The invention provides a quercetin nano sustained-release preparation capable of safely and effectively resisting silica-dust-caused pneumoconiosis fibrosis and a preparation method of the quercetin nano sustained-release preparation. The quercetin nano sustained-release preparation comprises poly (n-butyl cyanoacrylate) nanoparticles and quercetin loaded on the poly (n-butyl cyanoacrylate) nanoparticles. The invention provides the quercetin nano sustained-release preparation which is prepared by a spontaneous polymerization method by taking acetic acid as an initiator and is safe and effective in resisting silica-dust-caused pneumoconiosis fibrosis. According to the method, no toxic organic solvent is used for dissolving water-insoluble quercetin, instead, glacial acetic acid is used for dissolving the quercetin. The glacial acetic acid is weak acid, the acidity value changes slowly during pH adjustment, the pH value is easy to control, while strong acid hydrochloric acid cannot be used, acetic acid is easy to ionize acetate anions in water, the anions can be used as an initiator, and when a monomer is added into water, the monomer is automatically initiated to be polymerized into a polymer and nanoparticles can wrap quercetin, so that the solubility and bioavailability of the quercetin are improved. The method has the advantages of low cost, easiness in operation, low energy consumption, no pollution, high safety and the like.

Description

Technical field [0001] The present invention belongs to the technical field of quercetin nano sustaining preparations, mainly involving a safe and effective quercetin nano-sustained release formulation and preparation method thereof. Background technique [0002] my country is a coal big country. The productive dust is the main occupational hazard factor of coal mines. It can produce large amounts of dust during the production process of underground, and the operators have inhaled the harmful dust in the long-term labor and in the lungs retention, dust lungs. The most common in the disease is coal-fired and lungs and silicosis. Silica, ie silicon fibrosis is due to long-term suction of large amounts of dust (main components of SiO) 2 ), The clinical pathology of the pulmonary diffuse fibrosis is mainly manifested as a silicon, macropathic alveolar inflammation, and dust-dumping pulmonary fibrosis, is the most common in the lungs, the fastest progress The most serious type of harm...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/352A61K47/20A61K47/36A61K47/10A61K47/12A61K47/32A61P11/00B82Y5/00B82Y40/00
CPCA61K9/5026A61K31/352A61K47/20A61K47/36A61K47/10A61K47/12A61P11/00B82Y5/00B82Y40/00
Inventor 姚京京胡洁沈文文崔世华段聪慧苏伟刘仁谋
Owner ANHUI UNIV OF SCI & TECH
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