Medical novel biomaterial

A new material and biological technology, applied in the field of new medical biomaterials, can solve the problems of poor impact resistance, slow degradation speed, and insufficient bonding strength, and achieve the effect of improving impact resistance, moderate curing speed, and easy degradation.

Inactive Publication Date: 2019-01-29
端木顺娣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing medical glue has the disadvantages of poor impact resistance, slow degradation speed, and insufficient bonding strength

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 A new medical biological material, prepared from the following raw materials in parts by mass: 188 parts of butyl cyanoacrylate, 0.1 part of hydroquinone, 8 parts of aloe vera nanopowder, 55 parts of soybean protein powder, and 44 parts of chitosan , 5 parts of acetic acid; The preparation method is:

[0012] (1) Take fresh aloe, dry to a moisture content of 15%, and pulverize to a particle size of 300-500nm;

[0013] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 30% in deionized water, then add deionized water with 4 times the volume of the chitosan solution, heat to 50°C, add the remaining components, mix and stir Evenly, adjust the solid content to 25%.

Embodiment 2

[0014] Embodiment 2 A new medical biomaterial, prepared from the following raw materials in parts by mass: 100 parts of butyl cyanoacrylate, 0.051 parts of hydroquinone, 24 parts of aloe vera nanopowder, 20 parts of soybean protein powder, and 10 parts of chitosan 1 part of acetic acid; the preparation method is:

[0015] (1) Take fresh aloe, dry it to a moisture content of 20%, and pulverize it to a particle size of 300-500nm;

[0016] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 40% in deionized water, add deionized water with 3 times the volume of the chitosan solution, heat to 60°C, add the remaining components, mix and stir Evenly, adjust the solid content to 30%.

Embodiment 3

[0017] Example 3 A new medical biological material, prepared from the following raw materials in parts by mass: 200 parts of butyl cyanoacrylate, 0.01 part of hydroquinone, 22 parts of aloe vera nanopowder, 35 parts of soybean protein powder, and 30 parts of chitosan , 3 parts of acetic acid; The preparation method is:

[0018] (1) Take fresh aloe, dry it to a moisture content of 10%, and pulverize it to a particle size of 300-500nm;

[0019] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 20% in deionized water, then add deionized water twice the volume of the chitosan solution, heat to 40°C, add the remaining components, mix and stir Evenly, adjust the solid content to 20%.

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PUM

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Abstract

The invention discloses a medical novel biomaterial prepared from, by mass, 80-200 parts of butyl cyanoacrylate, 0.01-0.1 parts of hydroquinone, 5-24 parts of aloe nano-powder, 20-55 parts of soy protein powder, 10-44 parts of chitosan, and 1-5 parts of acetic acid. A preparation method includes: preparing a chitosan solution, concentration being 20-40%, with deionized water, adding the deionizedwater by 2-4 times by volume as the chitosan solution, heating the liquid to 40-60 DEG C and adding other components, uniformly mixing and stirring the liquid and regulating solid content to production demand. By adding the aloe nano-powder, anti-impact capacity of the material is improved; the material is easy to degrade due to natural plant extracts and components. The chitosan can improve antibacterial activity of the product. The material has a proper curing speed, is high in adhesion speed, is low in heat release during adhesion, has good flexibility of adhesion film, is low in skin irritation, has high-strength quick adhesion effect on various injuries and surgical incisions, and is free of scars after curing.

Description

technical field [0001] The invention relates to a new medical biological material, which belongs to the technical field of medical auxiliary products. Background technique [0002] Medical glue is an emerging medical product that replaces sewing needles. The main component of medical glue is a-cyanoacrylate, which has the fastest polymerization speed in biological tissues. Under the action of anions in wound blood and interstitial fluid, medical glue can quickly polymerize and solidify to form a film and inlay tightly with the wound, which can firmly maintain the apposition state of the wound, and the glue film can prevent blood cells and platelets from passing through. Under the joint action of protein, the broken small blood vessels on the wound surface can be effectively stopped bleeding, while the adhesive film isolates the tissue and bacteria, and also has the effect of anti-infection and protection of the wound surface. The ether chain in the polymer also has analgesi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/08A61L24/0005A61L24/001A61L24/108C08L5/08C08L89/00
Inventor 端木顺娣
Owner 端木顺娣
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