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Composition of EGCG and bamboo leaf flavonoid, preparation method and applications thereof

A technology of bamboo leaf flavonoids and composition, applied in the field of EGCG and bamboo leaf flavonoids composition, can solve the problems of restricted compliance, unacceptable, single action mechanism, etc.

Active Publication Date: 2015-08-12
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the disadvantage is that, on the one hand, the mechanism of action of EGCG in cardiovascular and cerebrovascular is relatively simple, and it lacks the functional effect of protecting cardiovascular and cerebrovascular in an all-round way or treating cardiovascular and cerebrovascular diseases; on the other hand, the taste of EGCG is very bitter, which limits the For its application in medicine and food, it is difficult for consumers or patients to accept its bitter and astringent taste when it is taken orally directly, which severely restricts its application compliance

Method used

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  • Composition of EGCG and bamboo leaf flavonoid, preparation method and applications thereof
  • Composition of EGCG and bamboo leaf flavonoid, preparation method and applications thereof
  • Composition of EGCG and bamboo leaf flavonoid, preparation method and applications thereof

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Effect test

Embodiment 1

[0257] Compound tablet of embodiment 1, EGCG and bamboo leaf flavone and preparation thereof

[0258] The prescription quantity is calculated by weight percentage and contains:

[0259] EGCG 5%~25%, preferably 15%,

[0260] Bamboo leaf flavonoids 10% to 40%, preferably 30%,

[0261] Mannitol 20%~35%, preferably 30%,

[0262] Calcium hydrogen phosphate 8% to 20%, preferably 17%,

[0263] Sodium carboxymethyl starch 1%~10%, preferably 5%,

[0264] Aqueous solution of hydroxypropyl cellulose Appropriate amount, preferably 2.5% aqueous solution of hydroxypropyl cellulose, calculated as 2% by hydroxypropyl cellulose,

[0265] Magnesium stearate 0.5% to 2%, preferably 1%;

[0266] The preparation method comprises: passing EGCG, bamboo leaf flavonoids, mannitol, calcium hydrogen phosphate, and sodium carboxymethyl starch through a 80-mesh sieve, preferably 100-mesh sieve, and mixing EGCG and mannitol evenly after weighing according to the prescription amount , to obtain A mixed...

Embodiment 2

[0267] The compound granule of embodiment 2, EGCG and bamboo leaf flavone and its preparation

[0268] The prescription quantity is calculated by weight percentage and contains:

[0269] EGCG 1%~10%, preferably 3%,

[0270] Bamboo leaf flavonoids 1% to 20%, preferably 10%,

[0271] Granule excipients 85% to 98%, preferably fructose 87%;

[0272] Wherein the granule excipients include one or more of the following ingredients: fructose, xylitol, fructooligosaccharides, polyfructose, xylooligosaccharides, polydextrose, mannitol, sucrose, invert sugar (i.e. glucose and fructose equal mixture of dextrins), glucose, resistant dextrin, sorbitol, maltose, isomalt, mannose oligosaccharides, solid polyethylene glycols (e.g. polyethylene glycol-4000, polyethylene glycol-12000 , polyethylene glycol-6000, polyethylene glycol-2000, etc.), dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hydroxy Propylmethylcellulose,...

Embodiment 3

[0274] The compound capsule of embodiment 3, EGCG and bamboo leaf flavone and preparation thereof

[0275] The prescription quantity is calculated by weight percentage and contains:

[0276]EGCG 10%~30%, preferably 15%,

[0277] Bamboo leaf flavonoids 15% to 45%, preferably 40%,

[0278] Mannitol 15%~35%, preferably 26%,

[0279] Pregelatinized starch 8%~25%, preferably 12%,

[0280] Sodium carboxymethyl starch 1% to 15%, preferably 5%,

[0281] The ethanol solution of polyvinylpyrrolidone is an appropriate amount, preferably 1% with polyvinylpyrrolidone,

[0282] Magnesium stearate 0.5% to 2%, preferably 1%;

[0283] Its preparation method comprises: passing EGCG, bamboo leaf flavonoids, mannitol, pregelatinized starch and carboxymethyl starch sodium through 80 mesh sieve respectively, preferably passing through 100 mesh sieve, weighing according to the prescription amount, firstly mixing EGCG and bamboo leaf Flavonoids are mixed evenly to obtain A mixed powder, which i...

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Abstract

The invention provides a composition containing EGCG and bamboo leaf flavonoid. The composition can be made into any pharmaceutically-acceptable dosage form, and the weight ratio of EGCG to bamboo leaf flavonoid is 0.05-2:1. The invention further discloses a preparation method of the composition and applications of the composition in preparation of drugs for protecting heart and cerebral vessels and tissues, relieving myocardial and cerebral ischemia, and reducing the happening rate of myocardial infarction, stroke, and cardiovascular diseases.

Description

technical field [0001] The invention relates to a health food composition, its preparation method and application, specifically the composition of EGCG and bamboo leaf flavonoids, its preparation method and application. The health product composition of the present invention includes but not limited to medicine, medical food, health food or functional food, common food and so on. Background technique [0002] EGCG, that is, epigallocatechin gallate, the structural formula is as follows, [0003] , [0004] EGCG is a natural compound extracted and separated from green tea. It is the most efficient active monomer component in tea polyphenols. It has good safety and a wide range of physiological activities. Studies have shown that EGCG has antithrombotic, anti Arteriosclerosis, protection of the nervous system, anti-free radical damage, anti-oxidation, anti-oxidative stress, anti-angiogenesis, regulation of immunity, protection of cardiovascular and cerebrovascular and ant...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/16A61K9/20A61K9/48A23L1/29A61P9/00A61P25/00A61P9/10A61K31/353A23L33/00
Inventor 张耿元王保红唐湘成
Owner FUZHOU QIANZHENG PHARMA
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