A nerve guide with contact guiding function and its preparation method and device

A nerve conduit and orifice technology, used in rayon manufacturing, hollow filament manufacturing, textiles and papermaking, etc., can solve the problem of not being able to fully simulate the real microenvironment of nerves, and avoid additional procedures and structures such as secondary processing. Uniform and stable shape

Active Publication Date: 2017-11-17
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nerve conduits guide the regeneration direction of synapses through physical contact, mechanical constraints, and longitudinal tension. However, the diameter of nerve conduits is generally about 1 mm, which is much larger than the characteristic scale of nerve cells (1-10 μm); therefore, Nerve conduits can only provide macroscopic guidance for nerve growth, and cannot fully simulate the real microenvironment of nerve growth in vivo

Method used

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  • A nerve guide with contact guiding function and its preparation method and device
  • A nerve guide with contact guiding function and its preparation method and device
  • A nerve guide with contact guiding function and its preparation method and device

Examples

Experimental program
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Effect test

Embodiment 1

[0082] Embodiment 1, preparation polyacrylonitrile nerve guide

[0083] In this embodiment, the polymer material is polyacrylonitrile (PAN), the solvent material is dimethyl sulfoxide (DMSO), and the non-solvent and coagulant material are deionized water. Polyacrylonitrile is dissolved in dimethyl sulfoxide to form a polymer solution with a concentration of 6-10w / w%. The polymer solution was stirred at room temperature for 8 hours so that the polymer could be uniformly dissolved, left to stand for 12 hours to remove air bubbles in the solution, and then dried and sealed for storage. Put the polyacrylonitrile solution and deionized water into two injection needles respectively, and under the control of the micro-syringe pump, the flow rate control range of the polymer solution and deionized water is 0.5–3ml / min. Spinnerets with smooth outer walls and inner holes and spinnerets with 12 and 16 grooves in the inner holes were used for preparation respectively, and the air gap hei...

Embodiment 2

[0084] Embodiment 2, preparation polylactic acid-glycolic acid copolymer nerve guide

[0085] In this example, the polymer material is polylactic acid-glycolic acid copolymer (PLGA), the solvent material is dimethyl sulfoxide (DMSO), and the non-solvent and coagulant material are deionized water. The polylactic acid-glycolic acid copolymer is dissolved in dimethyl sulfoxide to form a polymer solution with a concentration of 15-25w / w%. Polylactic acid-glycolic acid copolymer dissolves slowly under block conditions, and an ultrasonic cleaner can be used to vibrate for a short time to speed up the dissolution rate. The polymer solution was stirred at room temperature for 8 hours so that the polymer could be uniformly dissolved, left to stand for 12 hours to remove air bubbles, and then dried and sealed for storage. Put the polylactic acid-glycolic acid copolymer solution and deionized water into two injection needles respectively, and under the control of the micro-syringe pump, t...

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Abstract

The invention discloses a nerve conduit having a contact-type guiding function. The nerve conduit comprises a hollow thin-film tube body, wherein a longitudinal groove structure is formed in the inner wall of the hollow thin-film tube body; the invention also discloses a manufacturing device, which comprises a base, a lifting platform which is arranged on the base, two micro injection pumps and a spinning nozzle which are arranged on the top surface of the lifting platform, and a coagulation basin which is located below the spinning nozzle; the spinning nozzle comprises a spraying head and two layers of spraying holes in the spraying head; a spraying cavity, which is connected to one of the micro injection pumps, is formed in the spraying head; the top ends of the outer layer of spraying holes communicate with the spraying cavity; the top ends of the inner layer of spraying holes are externally connected to the other micro injection pump and the bottom ends extend out of the outer layer of spraying holes; and grooves, which extend in the axial direction of the inner layer of spraying holes, are formed in the outer walls of the inner layer of spraying holes. The invention also discloses a method for manufacturing the nerve conduit. The nerve conduit manufactured by the invention is simultaneously formed with the longitudinal groove structure in the inner wall of the nerve conduit in a manufacturing process; and the longitudinal groove structure is uniform and stable in shape, so that such additional processes as secondary processing are avoided.

Description

technical field [0001] The invention relates to a preparation method and equipment for a nerve guide, in particular to a nerve guide with a contact guiding function and a preparation method and device thereof. Background technique [0002] The nervous system can be divided into the central nervous system and its peripheral nervous system. Its role is to regulate and control the common activities of various systems in the human body, making the body a complete unity. With the substantial improvement of current production automation and traffic mechanization, the incidence of peripheral nervous system injury is increasing day by day. In daily life, various mechanical injuries, chemical drugs, local ischemia, and tumors can cause peripheral nerve damage. Limb dysfunction caused by peripheral nerve injury will seriously affect the quality of life of patients; therefore, the repair, regeneration and functional recovery of peripheral nerve injury have always been the focus of res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02D01D5/24
CPCA61F2/02A61F2240/002D01D5/24
Inventor 尹俊钮心嘉戴光立王宗焕傅建中
Owner ZHEJIANG UNIV
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