A nerve guide with contact guiding function and its preparation method and device

Abstract

The invention discloses a nerve conduit having a contact-type guiding function. The nerve conduit comprises a hollow thin-film tube body, wherein a longitudinal groove structure is formed in the inner wall of the hollow thin-film tube body; the invention also discloses a manufacturing device, which comprises a base, a lifting platform which is arranged on the base, two micro injection pumps and a spinning nozzle which are arranged on the top surface of the lifting platform, and a coagulation basin which is located below the spinning nozzle; the spinning nozzle comprises a spraying head and two layers of spraying holes in the spraying head; a spraying cavity, which is connected to one of the micro injection pumps, is formed in the spraying head; the top ends of the outer layer of spraying holes communicate with the spraying cavity; the top ends of the inner layer of spraying holes are externally connected to the other micro injection pump and the bottom ends extend out of the outer layer of spraying holes; and grooves, which extend in the axial direction of the inner layer of spraying holes, are formed in the outer walls of the inner layer of spraying holes. The invention also discloses a method for manufacturing the nerve conduit. The nerve conduit manufactured by the invention is simultaneously formed with the longitudinal groove structure in the inner wall of the nerve conduit in a manufacturing process; and the longitudinal groove structure is uniform and stable in shape, so that such additional processes as secondary processing are avoided.

Description

technical field [0001] The invention relates to a preparation method and equipment for a nerve guide, in particular to a nerve guide with a contact guiding function and a preparation method and device thereof. Background technique [0002] The nervous system can be divided into the central nervous system and its peripheral nervous system. Its role is to regulate and control the common activities of various systems in the human body, making the body a complete unity. With the substantial improvement of current production automation and traffic mechanization, the incidence of peripheral nervous system injury is increasing day by day. In daily life, various mechanical injuries, chemical drugs, local ischemia, and tumors can cause peripheral nerve damage. Limb dysfunction caused by peripheral nerve injury will seriously affect the quality of life of patients; therefore, the repair, regeneration and functional recovery of peripheral nerve injury have always been the focus of res...

AI Technical Summary

Problems solved by technology

[0004] Nerve conduits guide the regeneration direction of synapses through physical contact, mechanical constraints, and longitudinal tension. However, the diameter of nerve conduits is generally about 1 mm, which is much larger than the characteristic scale of nerve cells (1-10 μm); therefore, Nerve conduits can only provide macroscopic guidance for nerve growth, and cannot fully simulate the real microenvironment of nerve growth in vivo

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