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A kind of nerve injury repair material and its preparation method and application

A technology for nerve injury and repair materials, which is applied in the field of medical devices, can solve the problems of non-conductivity, insufficient mechanical strength, and rapid degradation, etc., and achieve the effect of increasing electrical conductivity, simple and feasible preparation process, and improving degradation performance

Active Publication Date: 2021-12-14
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Type I collagen nerve guides that have been marketed, as natural polymers, have insufficient mechanical strength, rapid degradation, and non-conductive characteristics, and there is still a certain gap between them and ideal nerve guides
In addition, there are many composite modification technologies of polymer materials and collagen in the existing research, but the compatibility between collagen and most polymer materials is poor, it is difficult to produce synergistic effects, and the solvent selection of the composite process is varied and the steps are complicated , the final effect is not ideal

Method used

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  • A kind of nerve injury repair material and its preparation method and application
  • A kind of nerve injury repair material and its preparation method and application
  • A kind of nerve injury repair material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1, preparation and performance testing of nerve guide

[0045] 1. Preparation of nerve guide

[0046] 1. Preparation of materials for nerve guides

[0047] Get collagen, chitosan, acetic acid aqueous solution (acetic acid concentration is 3%) and graphene and mix according to the concentration shown in Table 1, obtain mixed slurry. "%" in Table 1 represents g / 100mL.

[0048] 2. Inject into the mold

[0049] Take the 17 kinds of mixed slurries obtained in step 1 and inject them into hollow stainless steel cylindrical molds (diameter 6mm, length 30mm), then insert a central axis with a diameter of 4mm into the center of the mold, and then install fixing caps at both ends of the mold to fix the central axis.

[0050] 3. Freeze drying

[0051]1) Gradient freeze-drying: put the mold in step 2 in the elevator, the descending speed is 10 rpm, the angle is adjusted to 9, and the time interval is 1.5s. Maintain for 40 minutes, thaw for 2 hours in the freezer at -...

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PUM

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Abstract

The application discloses a nerve injury repairing material, its preparation method and application. The preparation method of the material comprises: solidifying and drying the following mixed solution: the solute of the mixed solution includes collagen and chitosan, and the solvent is an acid solution; the collagen in the mixed solution The concentration is 60-90mg / mL; the concentration of the chitosan in the mixed solution is 20-40mg / mL. The product of the present invention retains the advantages of the original collagen nerve repair product, has been significantly improved in suture performance and degradation performance, and can also increase the conductive function, which is more in line with the requirements of an ideal nerve guide. Repair, without adding new solvents, and without new chemical reagent residue problems.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a nerve injury repair material and its preparation method and application. Background technique [0002] With the improvement of industrial production mechanization and the development of transportation, the incidence of peripheral nerve injury is on the rise. About 2 million cases of this kind of nerve injury occur every year in our country. With the development of microsurgical equipment and technology, the clinical efficacy of peripheral nerve injury repair has been continuously improved. If the defect gap is short, it can be directly sutured or small gap bridging; if the defect distance is long, nerve tissue transplantation or nerve conduit bridging can be used. For short-distance defects, scar tissue is easy to form around the anastomosis at the broken end during direct suture repair, which hinders the regeneration of the nerve to the distal end, and the adhesion of the surro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/50A61L27/58
CPCA61L27/58A61L27/26A61L27/50A61L2430/32C08L89/00C08L5/08
Inventor 陈刚杨洪阳栗国贝孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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