A kind of nerve injury repair material and its preparation method and application

Abstract

The application discloses a nerve injury repairing material, its preparation method and application. The preparation method of the material comprises: solidifying and drying the following mixed solution: the solute of the mixed solution includes collagen and chitosan, and the solvent is an acid solution; the collagen in the mixed solution The concentration is 60-90mg / mL; the concentration of the chitosan in the mixed solution is 20-40mg / mL. The product of the present invention retains the advantages of the original collagen nerve repair product, has been significantly improved in suture performance and degradation performance, and can also increase the conductive function, which is more in line with the requirements of an ideal nerve guide. Repair, without adding new solvents, and without new chemical reagent residue problems.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a nerve injury repair material and its preparation method and application. Background technique [0002] With the improvement of industrial production mechanization and the development of transportation, the incidence of peripheral nerve injury is on the rise. About 2 million cases of this kind of nerve injury occur every year in our country. With the development of microsurgical equipment and technology, the clinical efficacy of peripheral nerve injury repair has been continuously improved. If the defect gap is short, it can be directly sutured or small gap bridging; if the defect distance is long, nerve tissue transplantation or nerve conduit bridging can be used. For short-distance defects, scar tissue is easy to form around the anastomosis at the broken end during direct suture repair, which hinders the regeneration of the nerve to the distal end, and the adhesion of the surro...

AI Technical Summary

Problems solved by technology

Type I collagen nerve guides that have been marketed, as natural polymers, have insufficient mechanical strength, rapid degradation, and non-conductive characteristics, and there is still a certain gap between them and ideal nerve guides

In addition, there are many composite modification technologies of polymer materials and collagen in the existing research, but the compatibility between collagen and most polymer materials is poor, it is difficult to produce synergistic effects, and the solvent selection of the composite process is varied and the steps are complicated , the final effect is not ideal

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