A kind of conductive nerve conduit based on butterfly lepidopteran and preparation method thereof

A nerve conduit and lepidopteran technology, applied in the field of neuroscience, can solve the problems of stimulating nerve cell growth and axon regeneration, poor electrical conductivity, no electrical conductivity, etc., to reduce time cost and economic cost, high degree of orientation, and promote The effect of regeneration

Active Publication Date: 2022-07-19
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional nerve repair scaffolds are unable to transmit electrical signals to stimulate and guide the growth of nerve cells and axon regeneration due to poor or even no conductivity.

Method used

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  • A kind of conductive nerve conduit based on butterfly lepidopteran and preparation method thereof
  • A kind of conductive nerve conduit based on butterfly lepidopteran and preparation method thereof
  • A kind of conductive nerve conduit based on butterfly lepidopteran and preparation method thereof

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Embodiment Construction

[0026] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0027] like figure 1 As shown, a kind of preparation method of the conductive nerve conduit based on butterfly lepidoptery, described nerve conduit is realized according to the following steps:

[0028] Cut out rectangular butterfly lepidopteran slices and conduct hydrophilic treatment with plasma. The scanning electron microscope image of butterfly lepidopteran can be as follows figure 2 shown. Wherein, the butterfly lepidoptery c...

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Abstract

The invention discloses a conductive nerve conduit based on butterfly lepidopteran and a preparation method thereof. The method comprises modifying reduced graphene oxide on the surface of butterfly lepidopteran and coating a layer of methacrylated gelatin solution containing neurotrophic factor BDNF, UV light cures it and then crimps it into a nerve guide. The micro-nano structures arranged in parallel on the inner surface of the prepared nerve conduit can guide the nerve cells to extend in the direction of the lepidopteran ridge, and the BDNF in the hydrogel can be slowly released, which can effectively promote nerve regeneration. This butterfly lepidopteran-based nerve conduit uses butterfly lepidoptery as a raw material, which is easy to obtain, low in cost, safe and non-toxic, and combines various factors that promote nerve regeneration, such as nano-bionics, directional induction, and sustained release of nutritional factors.

Description

technical field [0001] The invention relates to the field of neuroscience, in particular to a conductive nerve conduit based on butterfly lepidoptery and a preparation method thereof. Background technique [0002] Peripheral nerve injury is a very common disease. Once the nerve is missing, it means the loss of sensory and motor functions in some parts, which brings great pain to patients. Therefore, its repair and functional reconstruction has always been a major problem in the field of neuroscience. . Short-distance nerve defects can be repaired by autologous transplantation, but for long-distance defects, autologous transplantation has many problems such as insufficient donors. In recent years, the implantation of nerve guides to bridge the proximal and distal ends of the damaged nerve to repair nerve defects has been a research hotspot. [0003] Nerve conduits are usually tubular scaffolds made of biological materials to bridge the broken ends of nerves, provide a suita...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/50A61L27/54
Inventor 柴人杰赵远锦胡扬楠陈卓玥魏浩洪国栋
Owner SOUTHEAST UNIV
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