58results about How to "Promotes directional growth" patented technology

The invention relates to an application of a femto-second laser in the treatment of titanium or titanium alloy implanting material surface, belonging to the technical field of application of laser in the material surface treatment, which comprises the following steps: in the air, the femto-second laser pulses are arranged over the massive titanium or titanium alloy materials, are vertically focused on the surface to form a focal point, the laser spot radius of which is 5 Mum, the processing parameters of the femto-second laser are: the PRF is 1 kHz, the single pulse energy is 50 to 300 micro-joules, the pulse width is 50 femto-seconds, the pulse center wavelength is 800 nm, the laser processing line spacing is 10 to 100 Mum, and the laser scanning speed is 0.2 to 1.0mm/s; the polarization direction of the femto-second laser is adjusted to be parallel with the scanning direction of the femto-second laser, the femto-second laser is used to scan the entire surface of the massive titanium or titanium alloy materials which have been immersed in hydroxyl apatite suspension liquid for 5 minutes, so the surface of the titanium or titanium alloy materials present uniform rough peak-like protrusions and a pattern of porous cyclist regular structure, and is loaded with the titanium-based biomedical material of calcium and phosphate salt.

The invention aims to provide a neural restoration material combined with the acellular nerve application. The neural restoration material is prepared from nerves of an acellular allogene or acellular heterogeneous living organism, a restoration material, a microtubulin inhibitor, neurotrophic factors and stem cells. The neural restoration material disclosed by the invention has good biocompatibility, can provide nutrition supplies needed by nerve regeneration and restoration, is capable of maintaining an optimal physicochemical and biology microenvironment for nerve regeneration for a long time and has dual functions of preventing nerve tumor formation and promoting defect nerve restoration.

The invention discloses a preparation method for a CNT (carbon nano tube)-SAPO (silicoaluminophosphate)-5 molecular-sieve composite membrane. The preparation method comprises the following steps that: (1) synthetic liquid is prepared, and the molar composition of raw materials of the synthetic liquid is that Al2O3: P2O5: SiO2: Template: H2O: X equals to 1: a: b: c: d: e, wherein a is equal to 0.8-1.3, b is equal to 0.05-1, c is equal to 0.15-1, d is equal to 45-1000, and e is equal to 0.075-0.3; (2) a porous support is put into a high-pressure crystallization reaction kettle, the synthetic liquid is added to promote full crosslinking growth among molecular sieve crystals, and finally, the complete molecular sieve membrane is formed; and (3) an organic template is removed by the catalytic property of a heteroatoms-containing SAPO-5 molecular sieve. According to the invention, intergranular defects can be effectively prevented from forming in the molecular sieve membrane, and a split organic template agent can form a CNT tube in a molecular sieve pore passage so as to improve the hydrophobic property of the molecular sieve membrane. According to the invention, technological conditions are moderate, the operation is simpler, costs are lower, the applicability is wider, and not only is the large-scale production of molecular sieve membranes facilitated, but also the industrialized application of the molecular sieve membranes in separation of gas and separation of low-concentration organics is facilitated.

The invention relates to a high-simulation tissue engineering nerve-repair material and a preparation method. The high-simulation tissue engineering nerve-repair material is characterized by being prepared by one or two or all of I-type collagen, chitosan and gelatin. The material comprises, by weight, I-type collagen 1-10 parts and gelatin 1 part, can be used for basic research on nerve injury repair and bridging repair of injured or defected clinical human body spinal cord and peripheral nerves, facilitates growth of nerve regeneration fibers and can be used for repair of the injured spinal cord and the peripheral nerves.

The invention discloses a preparation method of a nerve defect repair material of a vessel basilar membrane imitating structure, and belongs to the fields of a tissue engineering technology and a biological material. On the basis of the arrangement of peripheral nerve collagen fibers and the structural characteristics of a nerve fiber vessel basilar membrane, the peripheral nerve defect repair material of the vessel basilar membrane imitating structure is prepared mainly from a high polymer material and a natural material in accordance with an electro-spinning technology and a pore-forming technology. Different from other nerve conduits, the cross section of the material is represented as a porous micro-tubular structure and fiber arrangement on the tube wall is highly oriented in a direction consistent with the moving direction of microtubule. The specific surface area of the tube wall of the material is significantly improved, and the structure of the microtubule is similar to that of the nerve fiber vessel basilar membrane; a plurality of nerve growth promoting substances can be added; and the tissue engineering peripheral nerve defect repair material is good in biocompatibility and convenient for the nerve fibers to grow in the direction of principal axis of the repair material, and the repair material has an application prospect.

The invention provides an electromagnetic forming device and method for manufacturing titanium aluminum-based alloy directional fully-lamellar microstructure. A shield cover is placed on an insulation plate located at the upper surface of a water cooled crystallizer, a positioning plate is placed at the upper surface of the shield cover, a forming sensor is located at the upper surface of the positioning plate, a thermal insulation sleeve is located in the inner ring of the forming sensor, a clip is fixed at the outer circumferential surface of the forming sensor, the central hole of the shield cover, the central hole of the forming sensor and the central hole of the thermal insulation sleeve are coaxial, a seed crystal is located in the central hole of the shield cover, the lower end of the seed crystal is connected with a draw bar in a vacuum chamber, a base material is located in the thermal insulation sleeve, the upper end of the base material is connected with a synchronization rod in the vacuum chamber, and the seed crystal and the base material alloy are coaxial with the central hole of the forming sensor. The electromagnetic forming device provided by the invention can completely eliminate the influence of crucible contamination on alloy constituents and structure, manufacture an ideal directional fully-lamellar microstructure and improve the positioning precision of the forming sensor.

The invention relates to the technical field of biological materials, in particular to a surface modification method of medical magnesium alloy. The surface modification method of the medical magnesium alloy aims at resolving the problems that the bonding force between a magnesium alloy base body and a coating is small, the magnesium alloy base body is prone to falling off, and the decomposition speed is too high in the later implantation period of the magnesium alloy. The surface modification method includes the steps that firstly, medical magnesium alloy materials are ground through abrasive paper, cleaned and then aired; secondly, cleaned medical magnesium alloy materials are put into a high-current pulse electron beam device to be radiated; thirdly, calcium and phosphorus electrolyte is prepared, and a hydroxyapatite coating is prepared on the surface of the medical magnesium alloy materials in a pulse electrodeposition mode. The surface modification method of the medical magnesium alloy improves the biological activity of the surface of the magnesium alloy, improves the corrosion resistance in the later implantation period of the magnesium alloy, obviously improves the bonding force between the hydroxyapatite and the base body, and overcomes the problems that the service life of a medical magnesium alloy implant is short, and the hydroxyapatite coating is prone to falling off.

The invention discloses a preparation method of a high-pore-density ultrathin-wall cordierite honeycomb ceramic carrier for a gasoline engine three-way catalytic converter. The preparation method comprises the following steps: (1) stirring an inorganic material, an organic dispersant and purified water to form a slurry, and carrying out spray drying on an inorganic powder by using a spray drying device to form a powder with excellent flowability; (2) carrying out dry mixing on the powder and an organic binder, then adding a lubricant and a dispersion medium, and carrying out wet mixing to enable the mixture to form plastic mud pellets; and (3) carrying out extrusion molding on the mud pellets obtained in step (2) to form a green body, and carrying out dielectric drying, hot air drying, cutting and firing on the green body to finally prepare the honeycomb ceramic product, wherein the inorganic material comprises acicular raw kaolin. According to the preparation method provided by the invention, the acicular raw kaolin is introduced, so that the prepared product has ultralow CTE, high yield and low cost.

The invention discloses a method for endowing a Ni-enriched TiNi shape memory alloy with a two-way shape memory characteristic. The method comprises the following steps: applying high-energy electrical stimulation to a constrained cold-formed TiNi shape memory alloy, coupling a Joule heating effect caused in a low temperature range of 150-250 DEG C with the electron wind effect, promoting the internal defects (such as dislocation) of the alloy to be in directional arrangement along a constraint stress direction, enabling a martensite variant to be in orientated growth, then 'memorizing' the cold forming state as a high temperature shape, 'memorizing' a high-temperature aging state as a low temperature shape, matching a mechanical training method to form the electrical stimulation-mechanical training method, and endowing the Ni-enriched TiNi shape memory alloy with the 'thermal expansion and cold contraction' type two-way shape memory characteristic. According to the method, the high-energy electrical stimulation and martensitic phase transition alternative cycle period duration can be greatly shortened, the production efficiency is improved, and the energy consumption is reduced.

The invention discloses a preparation method of a polyimide graphite film, which comprises the following steps: chopping plant fibers, carrying out micro-carbonization pretreatment, conducting dispersing in an organic solvent, adding diamine and dianhydride, carrying out in-situ polymerization reaction to obtain a polyamide acid solution containing micro-carbonized plant fibers, and carrying out imidization treatment to obtain a polyimide film containing the micro-carbonized plant fibers, and conducting carbonization and graphitization to obtain the polyimide graphite film. According to the preparation method, the micro-carbonized plant fibers are directly added into a polyimide synthesis system as an in-situ polymerization reaction carrier, and the polyimide graphite film containing the carbon nanotubes is prepared through direct graphitization, so that the performance of the graphite film can be improved, and the production cost of the graphite film is greatly reduced; and the greenand low-cost new method is provided for producing the high-performance graphite film.

The invention relates to the technical field of biomedical materials, in particular to a nerve-induced repair catheter stent and a preparation method and application thereof. The nerve-induced repair catheter stent is divided into an outer catheter stent and an inner filler, the inner filler is a gelatin modified high-molecular polymer and extracellular matrix composite material, and the stent with an oriented fiber arrangement structure is prepared through 3D printing photocuring. The outer tube stent is formed by compounding a high-molecular polymer material with reduced graphene oxide nanoparticles and is formed by using a 3D printer. An outer tube stent material has a good mechanical supporting structure and electrical stimulation responsiveness (reduced graphene oxide and rGO have good mechanical strength for improving polymers, and nanoparticles have electrical stimulation responsiveness), and an internal filling stent has a good fiber directional arrangement structure, so that the electrical stimulation responsiveness of the outer tube stent material is improved, and the electrical stimulation responsiveness of the outer tube stent material is improved. The obvious promoting effect is achieved on inducing axial growth of nerves.

The invention discloses a preparation method and application of silver-copper bimetal nanofibers, and belongs to the technical field of nanofiber preparation. The preparation method specifically comprises the following steps: uniformly mixing and stirring a copper salt solution, an organic halide solution, an end-capping reagent solution and a reducing agent solution, transferring the mixture intoa high-pressure reaction kettle, and reacting for 20-1440 minutes to obtain a copper nanofiber stock solution; washing and purifying the copper nanofiber stock solution to obtain copper nanofibers; adding an organic protective agent solution and a silver salt solution into the copper nanofiber solution, uniformly mixing, then transferring the mixture into a three-neck flask, and reacting for 10-360 minutes under the protection of inert gas to obtain a silver-copper bimetal nanofiber stock solution; and washing and purifying the silver-copper bimetal nanofiber stock solution to obtain the silver-copper bimetal nanofibers. The product finally obtained by the method has a high length-diameter ratio, mild reaction conditions, high repeatability and low cost, and is suitable for industrial popularization.

The invention discloses a method for producing an iolite cellular ceramic carrier. The method comprises the steps of burdening, dry blending, kneading and pugging. According to the invention, after pugging, pressurized sieving or/and vacuum sieving is carried out, and then steps of extrusion moulding, drying and sintering are carried out to obtain the iolite cellular ceramic carrier. A waste iolite cellular ceramic carrier forming die is employed during pressurized sieving as a screen mesh. In the invention, after pugging, a process of pressurized sieving or/and vacuum sieving is added, sieving by a dry method is removed, production efficiency is increased, energy consumption is reduced, moulding rate of the extruded finished product is increased, thermal expansion coefficient of the product is reduced, and the method has good application value.

The invention belongs to the technical field of ceramic materials, and discloses high-toughness oxidation-resistant textured high-entropy ceramic as well as a preparation method and application thereof. The molecular formula of textured high-entropy ceramic is (HfxZryTazCrnTim)B2, 0.1 <= x <= 1, 0.1 <= y <= 1, 0.1 <= z <= 1, 0.1 <= n <= 1, 0.1 <= m <= 1, and x + y + z + n + m = 1. The ceramic is prepared by the following steps: carrying out mold pressing on mixed powder of metal oxides to prepare a green body, heating the green body to 1400-1600 DEG C under a vacuum condition, carrying out heat treatment, grinding and screening the green body to obtain (HfxZryTazCrnTim)B2 textured high-entropy ceramic powder, heating the powder to 1000-1400 DEG C by spark plasma sintering, introducing a protective atmosphere, heating the mixture to 1800-2200 DEG C, and calcining the product. The textured high-entropy ceramic has a uniform solid solution phase, high toughness and oxidation resistance, and has a textured morphology directionally growing along a c-axis. The ceramic product can be applied to the field of ultrahigh-temperature oxidation resistance or cutters.

The invention discloses a preparation method of an oriented nanofiber nerve conduit, which comprises the following steps: (1) blending polylactic acid and gelatin, and dissolving in a hexafluoroisopropanol solution to prepare an electrostatic spinning solution; (2) adding nerve growth factors and astragalus polysaccharide into the electrostatic spinning solution; (3) preparing an oriented nanofiber nerve conduit by using an electrostatic spinning method; and (4) adding the nerve conduit into 0.1-2% of genipin solution for cross-linking, washing, and freeze-drying to obtain the nerve conduit. The nerve conduit prepared by the method has excellent biocompatibility, mechanical property and degradation property, and the nanofibers have directional distribution signals and can guide nerve cell axon extension. According to the preparation method, the synergistic effect of the medicine on promoting nerve regeneration is achieved, the nerve repairing rate is greatly increased, the astragalus polysaccharide can provide a good microenvironment for growth, proliferation and differentiation of nerve cells, and the occurrence of inflammatory reaction is reduced.