A kind of silk fibroin fiber hollow nerve guide and its preparation method and application

A technology of silk fibroin and nerve conduits, applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor mechanical properties and compression resilience, difficult cell growth preparation process, low porosity, etc., to achieve good compression Resilience performance, good biocompatibility and biodegradability, effect of high porosity

Active Publication Date: 2022-03-11
XI'AN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current nerve conduit scaffold materials have problems such as poor mechanical properties and compression resilience, low porosity, difficult cell growth, and complicated preparation processes.

Method used

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  • A kind of silk fibroin fiber hollow nerve guide and its preparation method and application
  • A kind of silk fibroin fiber hollow nerve guide and its preparation method and application
  • A kind of silk fibroin fiber hollow nerve guide and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Step 1: The silkworm cocoons are made of silkworm cocoons, and the silkworm cocoons are removed, and the silkworm cocoons are cut into pieces with scissors, and 1 part of the cut silkworm cocoons is weighed for later use; 0.5 parts of deionized water are taken with a measuring cylinder and added to a stainless steel iron pot, and heated in a microwave oven Until the deionized water boils; put 1 part of the cut cocoon into boiling deionized water and stir continuously with a glass rod, weigh 0.1 part of sodium carbonate and add it to a stainless steel pot, boil the cocoon for 10 minutes to remove the sericin; remove it with a glass rod Squeeze excess water out of silk fibroin fiber, wash silk fibroin fiber once with 1 part of deionized water to remove excess sodium carbonate in silk fiber; squeeze out excess water in silk fibroin fiber, put silk fibroin fiber by hand Tear it apart and spread it loosely on the aluminum foil, then place it in a fume hood for 1 day to allow ...

Embodiment 2

[0044]Step 1: The silkworm cocoon is made of silkworm cocoon, remove the silkworm cocoon, cut the silkworm cocoon into pieces with scissors, weigh 5 parts of the cut silkworm cocoon for later use; measure 1 part of deionized water with a measuring cylinder, add it to a stainless steel iron pot, and heat it on a microwave oven Until the deionized water boils; put 5 parts of silkworm cocoons into boiling deionized water and stir continuously with a glass rod, weigh 5 parts of sodium carbonate and add them to a stainless steel pot, boil the cocoons for 30 minutes to remove sericin; remove them with a glass rod Squeeze excess water out of silk fibroin fibers, wash silk fibroin fibers with 2 parts of deionized water for 3 times to remove excess sodium carbonate in silk fibers; squeeze out excess water in silk fibroin fibers, and wash silk fibroin fibers Tear it apart and spread it loosely on the aluminum foil, then place it in a fume hood for 2 days to allow the silk fibroin fiber t...

Embodiment 3

[0049] Step 1: The silkworm cocoon is made of silkworm cocoon, remove the silkworm cocoon, cut the silkworm cocoon into pieces with scissors, weigh 10 parts of the cut silkworm cocoon for later use; measure 2 parts of deionized water with a measuring cylinder, add it to a stainless steel iron pot, and heat it on a microwave oven Until the deionized water boils; put 10 parts of cut silkworm cocoons into boiling deionized water and stir continuously with a glass rod, weigh 10 parts of sodium carbonate and add it to a stainless steel pot, boil the silkworm cocoons for 60 minutes to remove sericin; fish out with a glass rod Squeeze excess water out of silk fibroin fiber, wash silk fibroin fiber with 3 parts of deionized water 3 times to remove excess sodium carbonate in silk fiber; squeeze out excess water in silk fibroin fiber, and wash silk fibroin fiber Tear it apart and spread it loosely on the aluminum foil, then place it in a fume hood for 3 days to allow the silk fibroin fib...

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Abstract

The invention discloses a silk fibroin fiber hollow nerve guide and its preparation method and application, belonging to the technical field of biomedical materials. Using natural silk fibroin as raw material, it has good biocompatibility and biodegradability. The hollow nerve guide prepared by swelling the silk fibroin fiber with polydioxanone / formic acid solution has good compression resilience. The raw material price is low, the sources are wide, the operation method is simple and the process flow is short, the hollow nerve guide with different size requirements can be prepared quickly and conveniently, and it can be mass-produced. The prepared silk fibroin fiber hollow nerve guide has very good mechanical properties and compression resilience, is not easy to cause the collapse of the support material, and can ensure the normal growth of nerve cells. The scaffold material has high porosity and many connected pores, and nerve cells can adhere, proliferate, migrate and grow on the nerve conduit material, which can promote the regeneration and repair of damaged nerves.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a silk fibroin fiber hollow nerve guide and a preparation method and application thereof. Background technique [0002] Traffic accidents, natural disasters and various accidental injuries usually lead to damage to the peripheral nerves of the human body, which will seriously affect the patient's motor and sensory nervous system, causing great pain to the patient and reducing their quality of life. Peripheral nerve injuries can be divided into small-segment nerve injuries and long-segment nerve injuries according to the degree of trauma. The peripheral nervous system itself has the function of regeneration and self-repair, so small nerve damage can be repaired automatically without manual surgery. However, for long-segment nerve injuries, the peripheral nervous system cannot automatically repair due to the long distance between the proximal end and the d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/18A61L27/50A61L27/56A61L27/58
CPCA61L27/227A61L27/18A61L27/50A61L27/56A61L27/58A61L2300/412A61L2430/32C08L89/00C08L67/04
Inventor 魏亮孙润军刘呈坤张昭环毛雪董洁
Owner XI'AN POLYTECHNIC UNIVERSITY
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