Method for preparing multi-channel antibacterial nerve guide by variable spindle braiding method

Abstract

The invention relates to a method for preparing a multi-channel antibacterial nerve conduit by a variable-spindle weaving method, comprising the following steps: braiding a plurality of inner conduit braiding yarns on the outside of an inner core material to form a conduit, and the conduit includes an inner core material and an inner core material. The tube body is sleeved on the outside; the color difference between the braided yarn of the inner conduit and the inner core material is obvious, and the inner core material is in the shape of a solid cylinder with a smooth surface. The number of braided yarns in the inner conduit can be estimated by the following formula ; Among them, m represents the number of braided yarns in the inner conduit, and d y Represents the diameter of the braided yarn of the inner catheter, R represents the inner diameter of the outer catheter, n represents the number of inner catheters in the multi-channel antibacterial nerve guide, r represents the inner radius of the inner catheter; 0<k≤1, 0<λ≤1; The catheter is divided into n tubes, and the n tubes are arranged side by side as the core material, and the outer catheter braided yarn is woven on the outside of the core material to form an outer catheter outside the core material, and then the inner core material is removed to obtain a multi-channel antibacterial nerve guide.

Description

technical field [0001] The invention relates to a preparation method of a nerve guide, in particular to a method for preparing a multi-channel antibacterial nerve guide by a variable spindle braiding method. Background technique [0002] Nerve injury is a difficult problem in medical treatment at present. When the distance of nerve defect is relatively large, the standard clinical practice is to use autologous nerve transplantation. However, there are many problems in autologous nerve transplantation. First, the nerve donor site will face functional or sensory impairment caused by secondary injury and nerve defect in the donor area; second, the size of different types of nerve fibers varies greatly, resulting in mismatch. The allogeneic nerve transplantation will appear immune rejection. Therefore, for long-distance nerve defects, people have been looking for reliable methods and ideal materials to prepare artificial nerve conduits for nerve repair to replace autologous ner...

AI Technical Summary

Problems solved by technology

[0005] In summary, most of the current technologies for preparing artificial nerve conduits with microporous channels are limited to the use of electrospinning and mold methods, or a combination of these two methods

The common disadvantages of the nerve guides prepared by these methods are poor repeatability of sample preparation, large batch-to-batch variance, and poor mechanical properties.

The spun membrane made by electrospinning has poor operability and is easy to deform and tear during the preparation of nerve conduits

The catheters made by the mold method often use the method of solvent volatilization and chemical cross-linking. The prepared catheters may have the problem of toxicity of the cross-linking agent. If genipin is used as the cross-linking agent, although the toxicity is not high, the cost is too high

If no cross-linking agent is used, the mechanical properties of the catheter are not ideal

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