The invention discloses a brain
myelin sheath-function
coupling calculation device based on
myelin sheath development double covariant. The device comprises image collection, wherein brain image data are collected through an MRI
scanner; data preprocessing: performing minimum preprocessing on the brain image data; quantifying the
myelin sheath content: calculating T1w / T2w to represent the
myelin sheath content and distribution thereof of brain tissues, and sampling the
voxel level T1w / T2w to the medium-thickness surface based on cortex reconstruction to reflect the cortical
myelin sheath content; constructing a multi-
modal brain connection group, wherein the multi-
modal brain connection group comprises a crowd level myelin development covariant
brain network gMC, an individual myelin development covariant
brain network sMC and a
grey matter function
brain network FC; calculating
myelin sheath-function
coupling: associating a
single node myelin sheath double covariant connection mode with a function communication connection mode based on a multivariate
linear model; and detecting significance of myelin sheath-function
coupling: analyzing a
spatial distribution mode of the MFC, detecting whether the MFC is specific to a real connection mode by using spin test, and analyzing and quantifying age-related development characteristics of the MFC, relevance between the MFC and a functional main gradient, and
linear correlation between the spatial mode of the MFC and
gene expression information.