Brain disease diagnosis method based on 3D convolutional neural network

A convolutional neural network and disease diagnosis technology, applied in the field of brain disease diagnosis, can solve problems such as lack of versatility, achieve wide versatility, improve accuracy and generalization ability, and have good application prospects

Inactive Publication Date: 2020-01-31
NANJING UNIV OF TECH
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Problems solved by technology

However, this feature extraction method can only be used for certain types of brain diseases and is not universal.

Method used

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  • Brain disease diagnosis method based on 3D convolutional neural network
  • Brain disease diagnosis method based on 3D convolutional neural network
  • Brain disease diagnosis method based on 3D convolutional neural network

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Embodiment 1

[0078] A method for diagnosing brain diseases based on a 3D convolutional neural network, comprising steps:

[0079] 1. The present invention selects 6,000 MRI brain images from the ADNI public data set, including three categories of patients with Alzheimer's disease, mild cognitive impairment patients, and normal people. There are 2,000 samples of MRI brain images in each category. It is divided into training set (5400 samples) and test set (600 samples) according to the ratio of 9:1.

[0080] 2. Preprocessing the obtained brain image data, the processing link mainly includes brain tissue extraction and sample standardization.

[0081] 2.1. Remove invalid slices that do not contain the brain through the global threshold segmentation method.

[0082] 2.2. Adjust the non-standard posture of the head of the person to be tested when the brain image is acquired through anterior joint-post joint correction.

[0083] 2.3. Skull stripping and cerebellar removal were performed on th...

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Abstract

The invention relates to a brain disease diagnosis method based on a 3D convolutional neural network. The method comprises the following steps: 1) acquiring MRI brain image data samples of normal states and diseases; 2) performing sample pretreatment: brain tissue extraction and sample standardization; 3) designing a 3D convolutional neural network for brain disease diagnosis; 4) taking the MRI brain image as the input of the 3D convolutional neural network, performing network training, extracting features, and establishing a classification diagnosis model; 5) preprocessing the MRI brain imageof the to-be-detected person, sending the preprocessed MRI brain image as input to the 3D convolutional neural network diagnosis model to obtain an output label, and judging whether the to-be-detected person is sick or not. The method has the advantages that 1) the brain disease diagnosis model is established by using the 3D convolutional neural network, and features are automatically learned from MRI brain images; a multi-hidden-layer deep learning model is constructed, accurate and effective features are automatically obtained by a computer, and finally the precision and generalization ability of the diagnosis model are improved; 2) the method is suitable for diagnosis of various different types of brain diseases such as Alzheimer's disease, depression, children hyperactivity and the like.

Description

technical field [0001] The invention is a method for diagnosing brain diseases based on a 3D convolutional neural network, which belongs to the technical field of diagnosing methods for brain diseases. Background technique [0002] With the increasing pace of life in contemporary society, the incidence of various brain diseases is increasing year by year. Brain diseases mainly include Alzheimer's disease, Parkinson's disease, autism, depression, and autism in children. At present, there are nearly one billion patients with brain diseases in the world. It can be seen that brain diseases have become an important factor that threatens people's health. Prompt intervention and treatment in the early stages of brain disease can prevent further deterioration of the disease. Therefore, the early diagnosis of brain diseases is very important, which is also a main research direction of "Chinese Brain Science". [0003] In recent years, neuroimaging technology has developed continuou...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/20G06N3/04G06K9/62
CPCG16H50/20G06V2201/03G06N3/045G06F18/2415
Inventor 王莉张鹏梅雪沈捷何毅曹磊
Owner NANJING UNIV OF TECH
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