1results about How to "Efficient induction" patented technology

The present application relates to DNA-peptide combination vaccine, provide the combination preparation for inducing specific immune response to antigen peptide, the preparation includes (I) the antigen peptide, and (II) expression vector, the expression vector encodes the chimeric hepatitis B virus core antigen polypeptide of the antigen peptide insertion or addition, wherein, the antigen peptide is inserted into the region of the amino acid residue 74~87 or 130~138 of hepatitis B virus core antigen polypeptide, or is added to the N terminal or C terminal of hepatitis B virus core antigen polypeptide, and the antigen peptide of (I) and the expression vector of (II) are substantially simultaneously administered to the subject.