70 results about "Critical factors" patented technology

The present invention relates to a method and composition for the cryopreservation of adipose tissue with the intention to use this tissue in the culturing of stem and/or progenitor cells. The method uses a specific cryoprotection medium to prevent damage of the original tissue during the cryopreservation while still maintaining a high viability of the stem and/or progenitor cells obtained from the cryopreserved adipose tissue. Furthermore the cryoprotection medium of the present invention does not contain any kind of xenogeneic sera, a critical factor since it is the intention of that the cryopreserved tissue is used for obtaining stem and/or progenitor cells that can be used in medicine. The cryoprotection medium is characterized in that it is a solution of physiological water comprising glycerol and sucrose and/or trehalose and optionally serum albumin.

The invention relates to a device for performing experiments by combining high-voltage pulse discharging and the traditional coal seam anti-reflection technology, in particular to a coal seam anti-reflection experiment device based on high-voltage electric pulse. The coal seam anti-reflection experiment device based on high-voltage electric pulse comprises a high-voltage pulse power supply, a first tube body, a second tube body, a third tube body, a rigid triaxial pressure chamber, a pressure testing pump, a hydraulic control system and a sound reflection preamplifier, wherein the first tube body, the second tube body and the third tube body are connected in sequence. The traditional hydraulic fracturing technology is simulated in the rigid triaxial pressure chamber, the high-voltage pulse power supply supplies power to a discharging electrode, therefore, the positions around a through hole of a coal sample fracture, a fracturing positions and an expanding process of the fractures in the coal sample are monitored all the time, critical factors affecting fracture development of the coal sample and state transformation of gas, an actuating range and effect laws of pulse discharging on fracture development can be obtained through the later CT scanning and electron microscopy observation results, and a theoretical foundation is provided for practical application of high-voltage pulse discharging into underground coal seam anti-reflection.

Methods of providing maintenance management of a machine are disclosed. In one embodiment, the method involves identifying a machine component failure that, if not repaired, will result in a functional failure of the machine. A criticality factor is assigned to the machine component failure based on at least a probability of occurrence of the functional failure and a consequence of the functional failure to a machine user. A maintenance task is generated to repair the machine component failure, and a triggering condition that activates the maintenance task is defined. The method further involves conducting a machine repair in response to a detection of the triggering condition, and maintaining a record that includes information relating to the conducted machine repair. The method of providing maintenance management is also modified based on at least the record.

An apparatus and method for improving the performance of an Internet website includes a performance processor that identifies a plurality of critical performance factors that facilitate improved website performance and then tests in real time, by utilization of an application programming interface, the influence of individual ones of said plurality of performance factors by application of a fractional factorial design.

The embodiment of the invention discloses a transient compensation method and a transient compensation system for nitrogen oxide discharging of an automobile engine. The method comprises the following steps of: acquiring fuel charge and engine speed, inquiring a steady state MAP to acquire steady state discharge of a nitrogen oxide, and determining the discharge as a basic value; determining rotation speed change rate, oil injection change rate, air inflow change rate, oil injection angular advance change rate, and oil injection pressure change rate; correcting the acquired values according to preset correction factors respectively; and taking the corrected values as the nitrogen oxide original discharge of the automobile engine. In the method and the system, critical factors influencing discharge are corrected, and the basic value acquired by inquiring the MAP table is compensated by the correct results, so that the calculated error between NOx concentration and actual concentration in a transient cycle is reduced, and basis is provided for subsequent improvement on discharge control and on-board diagnostics (OBD) monitoring accuracy.

A generating system of automatically generating electrical type product bill of materials of the present invention comprises a stock number grouping database, a stock number ranking database, and a bill of materials automatically generating processing program. The stock number grouping database comprises at least one material group records comprising at least a product group with the same electrical specification and at least one stock number group component supplier/vendor code. The stock number ranking database comprises at least one stock number ranking record, each stock number ranking record corresponds to one of the stock number group records and is used to record an evaluating rate after evaluating with the stock number group records according to a ranking critical factor. The bill of materials automatically generating processing program is used to generate a bill of materials of the corresponding electrical circuit design according to the bill of materials outline of the input electrical circuit design diagram, stock number grouping database, stock number ranking database, and a material choosing critical factor.

Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. Previously developed hydrophobic CPPs, named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD), are able to deliver biologically active proteins into a variety of cells and tissues. Various cargo proteins fused to these CPPs have been used to test the functional and/or therapeutic efficacy of protein transduction. For example, recombinant proteins consisting of suppressor of cytokine signaling 3 protein (CP-SOCS3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. However, CP-SOCS3 fusion proteins expressed in bacteria were hard to purify in soluble form. To address these critical limitations, CPP sequences called advanced MTDs (aMTD) have been developed in this art. This is accomplished by (i) analyzing previous developed hydrophobic CPP sequences to identify specific critical factors (CFs) that affect intracellular delivery potential and (ii) constructing artificial aMTD sequences satisfied for each critical factor. In addition, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. These recombinant SOCS3 proteins fused to aMTD/SD having much higher solubility/yield and cell-/tissue-permeability have been named as improved cell-permeable SOCS3 (iCP-SOCS3) proteins. Previously developed CP-SOCS3 proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. In the present art, iCP-SOCS3 proteins have been tested for use as anti-cancer agents in the treatment of hepatocellular carcinoma. Since SOCS3 is frequently deleted in and loss of SOCS3 in hepatocytes promotes resistance to apoptosis and proliferation, we reasoned that iCP-SOCS3 could be used as a protein-based intracellular replacement therapy for the treatment of hepatocellular carcinoma. The results support this reasoning: treatment of hepatocellular carcinoma cells with iCP-SOCS3 results in reduced cancer cell viability, enhanced apoptosis and loss of cell migration/invasion potential. Furthermore, iCP-SOCS3 inhibits the growth of hepatocellular carcinoma in a subcutaneous xenografts model. In the present invention with iCP-SOCS3 fused to an empirically determined combination of newly developed aMTD and customized SD, macromolecule intracellular transduction technology (MITT) enabled by the advanced MTD may provide novel protein therapy against hepatocellular carcinoma.

In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance. Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. Previously developed hydrophobic CPPs—named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD)—are able to deliver biologically active proteins into a variety of cells and tissues. Various cargo proteins fused to these CPPs have been used to test the functional and/or therapeutic efficacy of protein transduction. Previously, recombinant proteins consisting of suppressor of cytokine signaling 3 (SOSC3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. However, this SOCS3 fusion proteins expressed in bacteria cells were hard to be purified in soluble form. To address these critical limitations, CPP sequences called advanced MTDs (aMTDs) have been developed in this art. The development of this art has been accomplished by (i) analyzing previous developed hydrophobic CPP sequences to identify specific critical factors (CFs) that affect intracellular delivery potential and (ii) constructing artificial aMTD sequences that satisfy each critical factor. Furthermore, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. These recombinant SOCS3 proteins fused to aMTD/SD having much higher solubility/yield and cell-/tissue-permeability have been named as improved cell-permeable SOCS3 (iCP-SOCS3) proteins. Previously developed SOCS3 recombinant proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. In the present art, iCP-SOCS3 proteins have been tested for use as anti-angiogenic agents. Since SOCS3 is known to be an endogenous inhibitor of pathological angiogenesis, we reasoned that iCP-SOCS3 could be used as a protein-based intracellular replacement therapy for inhibiting angiogenesis in tumor cells. The results demonstrated in this art support this following reasoning: Cancer treatment with iCP-SOCS3 results in reduced endothelial cell viability, loss of cell migration potential and suppressed vascular sprouting potentials. In the present invention with iCP-SOCS3, where SOCS3 is fused to an empirically determined combination of newly developed aMTD and customized SD, macromolecule intracellular transduction technology (MITT) enabled by the advanced MTDs may provide novel protein therapy against cancer cell-mediated angiogenesis.

The present invention provides an elegant solution for processing multi-feature queries, which considers the differing access costs associated with each feature. Access cost is a critical factor in determining how individual features should be processed in terms of retrieving through sorted or random access, and, hence, in minimizing the overall query response time. The present invention operates dynamically during query processing and seeks to minimize the total query cost in terms of number of features retrieved and cost for access. It works by evaluating different combinations of feature access plans (sorted and random access) according to the number of retrieved features and forward access costs, and it selects the lowest cost plan. Experimental results on practical data show a significant speed-up in multi-features queries using the proposed solution.

The invention discloses an ion thruster operation life evaluation method based on grid corrosion. The method comprises the following steps of substituting a test measurement result and a numerical simulation calculation result into a semi-empirical analysis model; calculating to obtain the operation life of the ion thruster; evaluating the operation life of the ion thruster by using limited test data. Therefore, the most critical factors of the influence of the service life of the ion thruster can be quickly determined, the links of machining, manufacturing, assembling, testing, testing and the like of the thruster after failure are effectively reduced, the production cost of products is reduced, and the application range and the application value of the ion thruster can be predicted in advance.

A third-party platform electronic contracting system based on the electronic signature technology comprises contracting party client sides and a third-party contracting platform. Contracting parties hold the same or different digital certificates, and the third-party contracting platform is used for electronic contracting, can provide integrated verification and timestamps for different certificate chains, certificate states and certificate validity periods and guarantees accuracy and validity of mutual electronic contracting of the contracting parties held the same or different digital certificates issued by the CA (certification authority). The third-party platform electronic contracting system uses the electronic signature technology for decomposition, simulation, reconstruction, recombination and solidification of critical steps, critical factors and critical processes, so that technological holes of existing electronic contracting are made up, and accuracy and validity of electronic contracting are guaranteed.

An online detecting method for metal wire surface detects is provided. Surface defects are critical factors influencing quality in cold drawing processes of metal wires. The wire surface defects can be detected in real time in production and processing processes through the method. The method is based on an eddy current testing technique, utilizes an electromagnetic induction principle that eddy current is generated in a conductor through an exciting coil, and measures an eddy current change by means of an exploring coil, thus acquiring metal surface defect related information, and implementing the method. A detecting process is free of contact with an object to be detected and free of a coupling medium. The method is high in detection speed and precision and can meet online detection requirements.

Factors that are critical to the preparation of wood products and useful for flavoring aqueous food products are disclosed. As a result of identifying these critical factors, the herein described process produces a wood product that transfers the desired flavor profile to the aqueous food product efficiently and economically. The resultant wood squares produce excellent flavor in ten percent, or less, of the time it takes for traditional aging.

The invention provides a webpage testing factor selecting device which comprises a statistic module and a selecting module. The statistic module counts data information relevant to a plurality of webpage factors; and the selecting module judges important degrees of the webpage factors according to the data information, and selects the key testing factor from the webpage factors according to the important degrees of the webpage factors. Correspondingly, the invention further provides a webpage testing factor selecting method. According to the technical scheme, a critical factor in testing of a webpage system can be found out, so that webpage testing personnel can efficiently finish system testing and guarantee quality as much as possible.

Because of associated disadvantages of narrow-band off-chip radio-frequency (RF) filtering, a mixer-first receiver front-end designed to tolerate blockers with minimal gain compression and noise factor degradation is disclosed. The mixer-first receiver front-end includes two separate downconversion paths that help to minimize added noise and voltage gain prior to baseband filtering, which are critical factors in eliminating narrow-band off-chip RF filtering.

A method of forming a cluster from a plurality of potential clusters that share a common node, the method comprising determining a criticality factor of each potential cluster by combining criticality factors of the nodes of each potential cluster; and forming the cluster from the potential cluster with the highest criticality factor.

The invention relates to the technical field of biomedical detection. Pregnancy-hypertension syndrome is one of the critical factors resulting in death for gravida, puerpera, etus and infant. The current detection method is carried out mainly relying on the symptom existing clinically as well as based on some biochemical indicators; in fact, pregnancy-hypertension syndrome exists in early pregnantstage, while early detection landmark is lack in clinical practice for early detection and prevention of the disease. The invention aims at providing a hsa-mir-210 kit for detecting pregnancy-hypertension syndrome and a detection method thereof. By detecting variation of the hsa-mir-210 content in plasma or serum, the invention can more effectively carry out early detection on patients with pregnancy-hypertension syndrome and discover high-risk people with pregnancy-hypertension syndrome so as to prevent the disease effectively in time, and decrease occurrence of pregnancy-hypertension syndrome as well as related complication.

The present invention is in the fields of medicine, pharmaceuticals, nutraceuticals, endocrinology and cardiology. The invention provides compositions comprising a statin, an inhibitor of the angiotensin converting enzyme, an antiplatelet compound and an anti-hyperglycemic compound for use in the treatment and/or prevention of cardiometabolic risk factors of Metabolic Syndrome and treatment and/or prevention of Metabolic Syndrome. The present invention provides for the use of such compositions in the manufacture of products for treatment and/or prevention of Metabolic Syndrome. The biguanide metformin of the composition could be present in extended release form allowing its use together with the other drugs in a single dosage form at low dose. This combination of drugs in a single daily dosage greatly improves compliance and adherence to treatment which is a critical factor for treating patients with Metabolic Syndrome.

A system (10) for operating a display (12) as a human-machine interface suitable for use in an automated vehicle includes a display (12) and a controller (20). The display (12) is located in the vehicle so as to be viewable by an occupant of the vehicle, the display (12) being characterized by a display resolution (14) and a display size (16). The controller (20) communicates with the display (12). The controller (20) is configured to: determine how many components (24) can be shown on the display (12) based on the display size (16), determine a list of selected components (24) from the list of possible components (24), wherein each of the possible components (24) is characterized by a critical factor, and selected components (24) have a critical factor greater than a critical threshold, the configuration of each selected component is determined based on the display resolution (14), wherein the The configuration includes an aspect ratio as well as manipulating the display (12) to show the occupant selected components (24).

The invention discloses a process method for removing fluid inclusions in quartz sand by combining microwaves with acid leaching. According to the process method disclosed by the invention, microwave power is the most critical factor which affects the removal effect of the fluid inclusions in quartz sand, and a scientific and accurate treatment process is put forward. The process comprises the steps of: performing irradiation treatment on high-purity quartz sand by microwaves, wherein the microwave power is 1800-2400w; and then performing acid leaching by using monomer acid with a mass fraction of 5-15% for 6-24 hours, wherein the monomer acid is hydrochloric acid, nitric acid or hydrofluoric acid. A plenty of experiments verify that the light transmissivity of quartz sand materials treated by the process is stabilized to be not less than 90.0%, and reaches up to 99.2%, and the purity of SiO2 reaches 99.988%. The process method disclosed by the invention is simple to operate, stable and reliable and suitable for industrial production.