The invention relates to a route optimizing method for a logistic distribution vehicle. The method comprises the following steps: one, parameter setting and initializing; two, if Nc is less than or equal to Nmax, judging whether the iteration number reaches the maximum iteration number or not, if so, ending circulation and performing step seven; and otherwise, performing step three; three, merging and regulating a logistic distribution route; four, restructuring, inserting and regulating; five, evaluating the cost; six, selecting an optimal logistic distribution route scheme; and seven, obtaining the optimal route scheme for the logistic distribution vehicle. The method for optimizing the logistic distribution route improves the convergence property of the logistic distribution route optimization and can efficiently obtain the optimal logistic distribution route scheme through an abstract enterprise merging action and a merging method consisting of merging operation, restructuring operation and the like.