A portable audiometer for performing hearing testing enclosed within a patient response mechanism housing is disclosed. The audiometer may include a printed circuit board containing circuitry, plugs or other connectors for wired or wireless headphones and bone conductor, a battery charging unit, and one or more buttons for indicating response to pure tone and other stimuli, including, but not limited to noise, speech, and visual and audio instructions and graphical representations of objects or concepts used in a comprehensive hearing test. The instrument can be connected via a wired or wireless interface to a variety of controlling devices, including PC's, Personal Digital Assistants (PDA's), cellular phones, smartphones, including hybrid phone and PDA, and other devices such as media players, gaming systems, personal audio players, and other devices that can operatively communicate with the portable device.