A novel patient-convenient, cost effective pharmaceutical composition, comprising of thiazolidinediones and
biguanide for controlling hyperglycemia manufactured as
multilayer tablet and its process of manufacturing, for
immediate release of thiazolidinediones or thiazolidinediones and
biguanide and
prolonged release of the
biguanide only, the tablet comprising of minimum two
layers wherein one outer layer comprises of a mixture of excipients and thiazolidinediones or thiazolidinediones and biguanide allowing
immediate release of thiazolidinediones or thiazolidinediones and biguanide respectively and the other layer arranged in contact with the
immediate release layer which comprises of a novel composition of excipients and a minimum one or more non-biodegradable,
inert polymer(s) and the biguanide allowing
pH independent prolonged release of the biguanide up to a period of 8-12 hours. The tablets are for once a day dosing. The tablets may optionally be film coated or enrobed by soft
gelatin ribbons for additional protection against oxidation,
photodegradation, identification, ease of
swallowing,
taste masking and for aesthetic appeal without altering the
dissolution profile.