The present application provides a long-term stable S-2-(2-fluoro-4-
biphenyl) propionic acid-containing pharmaceutical composition, and a S-2-(2-fluoro-4-
biphenyl) propionic acid-containing patch and a preparation method thereof, the pharmaceutical composition comprising: S-2-(2-fluoro-4-
biphenyl) propionic acid or a pharmaceutically acceptable salt thereof,
menthol oil and a stabilizer, the stabilizer being selected from at least one of
isopropyl myristate, crotamiton and
laurocapram. The S-2-(2-fluoro-4-biphenyl) propionic acid-containing pharmaceutical composition of the present application, with at least one of
isopropyl myristate, crotamiton and
laurocapram as a stabilizer added to the composition of S-2-(2-fluoro-4-biphenyl) propionic acid and
menthol oil, can significantly improve the storage stability of the composition, compared with the prior art, the content of the
active ingredient S-2-(2-fluoro-4-biphenyl) propionic acid is further inhibited from decreasing over time.