Composition for dispelling effects of alcohol and protecting liver and preparation method thereof

Abstract

The invention discloses a hangover alleviating and liver protecting composition, which is prepared from the following components in parts by mass: 5 to 20 parts of radix puerariae extract, 5 to 20 parts of semen hoveniae extract, 5 to 20 parts of silybum marianum extract, 1 to 20 parts of rhizoma curcumae longae extract, 1 to 20 parts of rhizoma gastrodiae extract, 1 to 10 parts of lucid ganoderma extract, 1 to 20 parts of folium cortex eucommiae extract, 1 to 10 parts of fructus corni extract and 1 to 30 parts of corn oligopeptide powder. 1-50 parts of maltodextrin, 1-10 parts of microcrystalline cellulose, 1-2 parts of silicon dioxide and 1-2 parts of magnesium stearate. The total alcoholism-relieving and liver-protecting composition has the following beneficial effects: for acute drunkenness, the discomfort of drunkenness is obviously reduced, the chronic injury of alcohol to the liver is reduced, the systematic effect from alcohol metabolism to organ protection is realized through multi-target regulation and control, and the three-in-one effect of relieving alcoholism, protecting cells and regulating metabolism is achieved. The invention also discloses a preparation method of the alcohol effect dispelling and liver protecting composition.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a hangover-relieving and liver-protecting composition and a preparation method thereof. Background Art

[0002] Alcohol-relieving and liver-protecting compositions are currently a commonly used alcohol-relieving drug. Patent publication CN114668830B discloses a composition that can be used for alcohol-relieving and liver-protecting. This alcohol-relieving and liver-protecting composition is first extracted by placing each composition in water, and then adding honey after the extraction is completed. Because honey contains botulinum spores, botulinum spores will germinate into botulinum when conditions are right, and botulinum will produce botulinum toxin. The presence of botulinum toxin will cause diarrhea and vomiting in the user, further increasing the user's discomfort after being drunk. Summary of the Invention

[0003] In view of the above problems, the present invention provides a hangover-relieving and liver-protecting composition.

[0004] The technical solution adopted by the present invention is as follows: A hangover-relief and liver-protecting composition comprises, by weight, 5-20 parts of kudzu root extract, 5-20 parts of hovenia dulcis fruit extract, 5-20 parts of milk thistle extract, 1-20 parts of turmeric extract, 1-20 parts of gastrodia elata extract, 1-10 parts of ganoderma lucidum extract, 1-20 parts of eucommia leaf extract, 1-10 parts of cornus officinalis extract, 1-30 parts of corn oligopeptide powder, 1-50 parts of maltodextrin, 1-10 parts of microcrystalline cellulose, 1-2 parts of silicon dioxide, and 1-2 parts of magnesium stearate.

[0005] In this composition, the functions of each component are as follows: Pueraria root extract: accelerates ethanol metabolism by activating ADH (alcohol dehydrogenase) / ALDH enzymes and alleviates hangover symptoms.

[0006] Hovenia dulcis fruit extract: The dihydromyricetin it contains can activate ADH (alcohol dehydrogenase), thereby accelerating ethanol metabolism and thus sobering up; at the same time, Hovenia dulcis fruit polysaccharides can reduce the impact of alcohol on intestinal flora and reduce the probability of gastrointestinal discomfort and diarrhea caused by alcohol stimulation.

[0007] Milk thistle extract: The silymarin it contains can play a certain role in repairing liver cell membranes, and the silybin it contains can inhibit the activation of hepatic stellate cells, reverse liver fibrosis, and alleviate the damage to the liver caused by alcohol.

[0008] Turmeric extract: The volatile oils it contains can improve intestinal flora and reduce the probability of gastrointestinal discomfort and diarrhea caused by alcohol stimulation.

[0009] Gastrodia elata extract: The vanillin it contains can clear ROS and inhibit TRPV1 channels, thereby relieving headaches caused by drunkenness.

[0010] Ganoderma lucidum extract: inhibits the release of inflammatory mediators and relieves inflammatory reactions such as arthritis, back and leg pain caused by drinking. Eucommia leaf extract: The chlorogenic acid it contains can serve as an antibacterial agent for the entire composition, effectively extending the shelf life of the entire composition. In addition, the Eucommia flavonoids it contains can activate macrophage activity and promote the proliferation of beneficial bacteria, thereby alleviating the damage of alcohol to the intestinal flora.

[0011] Cornus officinalis extract: promotes liver cell repair, improves liver antioxidant capacity, and reduces the metabolic burden on the liver and kidneys.

[0012] Corn oligopeptide powder: Increases the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase in the liver, accelerates the decomposition of alcohol, reduces the burden on the liver, scavenges free radicals, enhances the repair ability of liver cells, and alleviates liver damage caused by alcohol. Maltodextrin: Maltodextrin can be quickly broken down into monosaccharides such as glucose, providing the body with immediate energy and allowing drinkers to quickly recover their strength after drinking. In addition, the oligosaccharides it contains can act as prebiotics to stimulate the growth of beneficial bacteria such as bifidobacteria, alleviating the damage of alcohol to intestinal flora.

[0013] Microcrystalline cellulose: acts as a disintegrant and binder, accelerating drug release and improving bioavailability.

[0014] Silica: acts as an auxiliary agent.

[0015] Magnesium stearate: acts as an auxiliary agent.

[0016] In summary, in this composition, Pueraria root and Hovenia dulcis fruit together accelerate metabolism, Milk thistle and Turmeric protect the liver and reduce liver damage, Gastrodia elata and Ganoderma lucidum relieve headaches caused by drinking and enhance immunity, Eucommia ulmoides and Cornus officinalis accelerate alcohol excretion and protect the kidneys, reducing the metabolic burden on the liver and kidneys. Puerarin in Pueraria root inhibits the alcohol-induced apoptosis pathway in hepatocytes, reducing peak blood ethanol concentrations; dihydromyricetin in Hovenia dulcis fruit inhibits gastrointestinal absorption of ethanol, and when used in combination with Pueraria root, it increases acetaldehyde dehydrogenase activity and accelerates alcohol metabolism; curcumin in Turmeric inhibits inflammatory responses, reduces inflammatory damage to the gastric mucosa and liver cells, scavenges free radicals produced by alcohol metabolism, and enhances the CYP450 enzyme system (especially CYP2E1). The activity of silymarin accelerates the conversion of acetaldehyde to acetic acid, accelerating the early detoxification of alcohol. Components in milk thistle, particularly silybin, inhibit lipid peroxidation and, when used in combination with turmeric, enhances liver cell membrane stability, thus protecting hepatocytes. Gastrodin in Gastrodia elata enhances GABA neuron activity, shortens the duration of alcohol-induced movement disorders, and relieves headaches associated with alcohol consumption. Triterpenoids in Ganoderma lucidum reduce tumor necrosis factor-α secretion by immune cells in the brain, reducing inflammation. Ganoderma lucidum polysaccharides promote hepatocyte regeneration, improve liver function, and enhance immunity. Geniposide acid in Eucommia ulmoides promotes fatty acid β-oxidation in the liver, reducing alcohol-induced fat accumulation and improving alcoholic fatty liver disease. It also protects hepatocyte mitochondrial function, maintains ATP production efficiency, and enhances hepatocyte detoxification. Eucommia ulmoides also have renal protective effects by regulating Na+ / K+-ATPase activity, alleviating alcohol-induced electrolyte imbalances. Eucommia ulmoides also have endothelial repair properties, inhibiting alcohol-induced oxidative damage to the endothelium. Cornus officinalis contains multiple active ingredients, such as morroniside and cornusin, which have significant antioxidant and anti-inflammatory properties, metabolic regulation, and liver and kidney protection. They can eliminate acetaldehyde toxicity and repair damage. Corn oligopeptide powder activates alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH2), promoting the conversion of ethanol to acetic acid. This inhibits alcohol-induced lipid peroxidation, protects liver cell membrane integrity, and alleviates liver damage. Hydrophobic amino acids (such as leucine and isoleucine) in corn officinalis can directly scavenge hydroxyl free radicals and superoxide anions, reducing post-exercise blood lactate accumulation, prolonging time to exhaustion, and alleviating fatigue.

[0017] This product combination significantly reduces the discomfort caused by acute drunkenness, reduces the chronic damage of alcohol to the liver, and achieves a systemic effect from alcohol metabolism to organ protection through multi-target regulation, playing the trinity role of "detoxification - cell protection - metabolism regulation".

[0018] Optionally, 1-50 parts of sorbitol are further included. The addition of sorbitol serves as a preservative to extend the storage time of the composition as much as possible.

[0019] Optionally, 20 parts of Pueraria root extract, 15 parts of Hovenia dulcis extract, 10 parts of Milk thistle extract, 10 parts of Turmeric extract, 2 parts of Gastrodia elata extract, 2 parts of Ganoderma lucidum extract, 2 parts of Eucommia ulmoides leaf extract, 2 parts of Cornus officinalis extract, 1 part of corn oligopeptide powder, 30 parts of maltodextrin, 4 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 1 part of magnesium stearate.

[0020] Optionally, 10 parts of Pueraria root extract, 15 parts of Hovenia dulcis fruit extract, 5 parts of Milk thistle extract, 5 parts of Turmeric extract, 1 part of Gastrodia elata extract, 1 part of Ganoderma lucidum extract, 1 part of Eucommia ulmoides leaf extract, 1 part of Cornus officinalis extract, 1 part of corn oligopeptide powder, 50 parts of maltodextrin, 8 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 1 part of magnesium stearate.

[0021] Optionally, 20 parts of Pueraria root extract, 20 parts of Hovenia dulcis fruit extract, 20 parts of Milk thistle extract, 20 parts of Curcuma longa extract, 20 parts of Gastrodia elata extract, 10 parts of Ganoderma lucidum extract, 20 parts of Eucommia ulmoides leaf extract, 10 parts of Cornus officinalis extract, 10 parts of corn oligopeptide powder, 30 parts of maltodextrin, 10 parts of microcrystalline cellulose, 2 parts of silicon dioxide, and 2 parts of magnesium stearate.

[0022] Optionally, 5 parts of Pueraria root extract, 5 parts of Hovenia dulcis extract, 5 parts of Milk thistle extract, 1 part of Curcuma longa extract, 1 part of Gastrodia elata extract, 1 part of Ganoderma lucidum extract, 1 part of Eucommia ulmoides leaf extract, 1 part of Cornus officinalis extract, 1 part of corn oligopeptide powder, 50 parts of maltodextrin, 10 parts of sorbitol, 10 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 0.5 parts of magnesium stearate.

[0023] A method for preparing the above-mentioned alcohol-relieving and liver-protecting composition comprises the following steps: S1 (raw material grinding step), grinding Pueraria root into Pueraria powder, grinding Hovenia dulcis fruit into Hovenia dulcis fruit powder, grinding Milk thistle into Milk thistle powder, grinding Turmeric into Turmeric powder, grinding Gastrodia elata into Gastrodia elata powder, grinding Ganoderma lucidum into Ganoderma lucidum powder, grinding Eucommia ulmoides leaf into Eucommia ulmoides leaf powder, and grinding Cornus officinalis into Cornus officinalis powder; S2 (extraction step), pouring the raw materials into 70% ethanol solution for extraction, and concentrating and spray-drying the extracts after extraction to obtain Pueraria root extract, Hovenia dulcis fruit extract, Milk thistle extract, Curcuma longa extract, Gastrodia elata extract, Ganoderma lucidum extract, Eucommia ulmoides leaf extract, and Cornus officinalis extract; S3 (mixing step), mixing kudzu root extract, hovenia dulcis fruit extract, milk thistle extract, turmeric extract, gastrodia elata extract, ganoderma lucidum extract, eucommia leaf extract, cornus officinalis extract, cornus officinalis extract, corn oligopeptide powder, maltodextrin, microcrystalline cellulose, silicon dioxide and magnesium stearate.

[0024] Optionally, the method further comprises a tabletting step of pressing the mixture obtained in the mixing step into tablets.

[0025] The beneficial effects of the present invention are: significantly reducing the discomfort of acute drunkenness, reducing the chronic damage of alcohol to the liver, and achieving a systemic effect from alcohol metabolism to organ protection through multi-target regulation, playing the trinity role of "detoxification - cell protection - metabolism regulation". DETAILED DESCRIPTION

[0026] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below.

[0027] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0028] Example 1

[0029] A hangover-relieving and liver-protecting composition comprises, by mass, 20 parts of kudzu root extract, 15 parts of hovenia dulcis fruit extract, 10 parts of milk thistle extract, 10 parts of turmeric extract, 2 parts of gastrodia elata extract, 2 parts of ganoderma lucidum extract, 2 parts of eucommia leaf extract, 2 parts of cornus officinalis extract, 1 part of cornus oligopeptide powder, 30 parts of maltodextrin, 4 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 1 part of magnesium stearate.

[0030] Example 2

[0031] A hangover-relief and liver-protecting composition comprises, by mass, 20 parts of kudzu root extract, 15 parts of hovenia dulcis fruit extract, 10 parts of milk thistle extract, 10 parts of turmeric extract, 2 parts of gastrodia elata extract, 2 parts of ganoderma lucidum extract, 2 parts of eucommia leaf extract, 2 parts of cornus officinalis extract, 1 part of cornus oligopeptide powder, 30 parts of maltodextrin, 4 parts of microcrystalline cellulose, 1 part of silicon dioxide, 1 part of magnesium stearate, and 1 part of sorbitol.

[0032] Example 3

[0033] A hangover-relief and liver-protecting composition comprises, by mass, 20 parts of kudzu root extract, 20 parts of hovenia dulcis fruit extract, 20 parts of milk thistle extract, 20 parts of turmeric extract, 20 parts of gastrodia elata extract, 10 parts of ganoderma lucidum extract, 20 parts of eucommia leaf extract, 10 parts of cornus officinalis extract, 10 parts of cornus oligopeptide powder, 30 parts of maltodextrin, 10 parts of microcrystalline cellulose, 2 parts of silicon dioxide, and 2 parts of magnesium stearate.

[0034] Example 4

[0035] A method for preparing the alcohol-relieving and liver-protecting composition as shown in Example 1 comprises the following steps.

[0036] S1 (raw material grinding step), grinding Pueraria root into Pueraria powder, grinding Hovenia dulcis fruit into Hovenia dulcis fruit powder, grinding Milk thistle into Milk thistle powder, grinding Turmeric into Turmeric powder, grinding Gastrodia elata into Gastrodia elata powder, grinding Ganoderma lucidum into Ganoderma lucidum powder, grinding Eucommia ulmoides leaf into Eucommia ulmoides leaf powder, and grinding Cornus officinalis into Cornus officinalis powder; S2 (extraction step), pouring the raw materials into 70% ethanol solution for extraction, and concentrating and spray-drying the extracts after extraction to obtain Pueraria root extract, Hovenia dulcis fruit extract, Milk thistle extract, Curcuma longa extract, Gastrodia elata extract, Ganoderma lucidum extract, Eucommia ulmoides leaf extract, and Cornus officinalis extract; S3 (mixing step), mixing kudzu root extract, hovenia dulcis fruit extract, milk thistle extract, turmeric extract, gastrodia elata extract, ganoderma lucidum extract, eucommia leaf extract, cornus officinalis extract, cornus officinalis extract, corn oligopeptide powder, maltodextrin, microcrystalline cellulose, silicon dioxide and magnesium stearate.

[0037] S4 (tabletting step) is to compress the mixture obtained in the mixing step into tablets.

[0038] Detection comparison experiment 1 (1) One hundred and twenty male Kunming mice, weighing (26±2) g, were randomly divided into six groups, with 20 mice in each group. The six groups were blank control group, white wine model group, comparative group, and three example groups. All mice were fed with standard feed for one week at room temperature of (22±2)°C with free access to water and food.

[0039] The hangover-relieving and liver-protecting composition provided by the comparative example group was gavaged to the comparative example group at a dose of 400 mg / kg for 14 consecutive days; the hangover-relieving and liver-protecting composition provided by Example 1 was gavaged to the three example groups at doses of 100 mg / kg, 200 mg / kg and 400 mg / kg, respectively, for 14 consecutive days; the blank control group and the white wine model group were gavaged with an equal amount of normal saline for 14 consecutive days.

[0040] One hour after administration on the last day, the liquor model group, the comparative example group and the three example groups were all orally administered with 52° liquor at a dose of 16 mL / kg; the blank control group was orally administered with an equal amount of normal saline.

[0041] The disappearance and recovery of the righting reflex of the mice were used to determine their drunken state and sobriety. After the liquor was poured in, the mice were placed with their backs facing downwards. If this posture lasted for more than 30 seconds, they were considered drunk. Otherwise, they were sober. The time of liquor administration, the disappearance and recovery time of the righting reflex of the mice were recorded, and the drunkenness time, sleep time and sobriety time were calculated.

[0042] Twelve hours later, blood was collected from the eyeball under anesthesia and placed in a 4°C freezer. After 30 minutes, the plasma was centrifuged at 3500 RPM for 20 minutes to separate the blood. Serum was stored at -80°C and assayed for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities using a kit.

[0043] In this comparative experiment, the comparative example group selected the composition shown in Example 7 disclosed in patent publication document CN114668830B.

[0044] The drunkenness, sleep and soberness time of mice are shown in Table 1: Table 1

[0045] Note: * indicates significant difference compared with the liquor model group (p<0.05); # indicates significant difference compared with the control group (p<0.05).

[0046] The effects of the alcohol-relieving and liver-protecting composition on the ALT / AST activity in the serum of mice with acute liver injury due to alcohol are shown in Table 2: Table 2

[0047] Note: * indicates that the experimental group has a significant difference compared with the liquor model group (p<0.05); # indicates that the experimental group has a significant difference compared with the control group (p<0.05); △ indicates that the experimental group has a significant difference compared with the blank control group (p<0.05).

[0048] As shown in Table 1, compared to the baijiu model group, the duration of intoxication in the Example group mice was significantly prolonged and the sobering time was significantly shortened. The hangover sobering activity of the medium dose (200 mg / kg) of the alcohol-relieving and liver-protecting composition was comparable to that of the control group. Compared to the control group, the duration of intoxication in the Example group mice at the high dose (400 mg / kg) was significantly prolonged and the sobering time was significantly shortened. As shown in Table 2, the serum ALT activity and AST activity of the medium- and high-dose example groups and the comparative example group were significantly lower than those of the liquor model group (p<0.05), and the serum ALT activity and AST activity of the medium- and high-dose example groups were significantly lower than those of the comparative example group (p<0.05). There was no significant difference in serum ALT activity and AST activity between the high-dose example group and the blank control group, indicating that the composition of Pueraria lobata extract, Hovenia dulcis fruit extract, Silybum marianum extract, Curcuma longa extract, Gastrodia elata extract, Ganoderma lucidum extract, Eucommia ulmoides leaf extract, Cornus officinalis extract and corn oligopeptide powder provided by the present invention has an extremely significantly better alcohol detoxification and liver protection effect than the composition shown in Example 7 disclosed in CN114668830B.

[0049] Detection comparison experiment 2 (1) One hundred male Kunming mice, weighing (26±2) g, were randomly divided into five groups, with 20 mice in each group. The five groups were: a liquor model group, a control group, and three example groups. All mice were fed with standard feed for one week at room temperature of (22±2)°C with free access to water and food.

[0050] (2) The alcohol-detoxifying and liver-protecting composition provided by the comparative example group was gavaged to the comparative example group at a dose of 400 mg / kg for 14 consecutive days; the alcohol-detoxifying and liver-protecting composition provided by Example 1 was gavaged to the three example groups at doses of 100 mg / kg, 200 mg / kg and 400 mg / kg, respectively, for 14 consecutive days; and the white wine model group was gavaged with an equal amount of normal saline for 14 consecutive days.

[0051] (3) One hour after administration on the last day, the liquor model group, the control group, and the three example groups were all gavaged with 52° liquor at a dose of 16 mL / kg.

[0052] (4) One hour after oral gavage, blood was collected from the mice through the carotid artery under light anesthesia, and serum was prepared and the ethanol content (BAC) in the serum was detected.

[0053] In this comparative experiment, the comparative example group selected the composition shown in Example 7 disclosed in patent publication document CN114668830B.

[0054] Blood alcohol clearance rate (%) = [(BAC value of model group - BAC value of sample group) / blood alcohol value of model group] × 100% The blood alcohol concentrations of mice are shown in Table 3: Table 3

[0055] Note: * indicates significant difference compared with the model group (p<0.05); # indicates significant difference compared with the control group (p<0.05).

[0056] As shown in Table 3, the blood alcohol concentration of the intoxicated mice in the Example group was significantly lower than that in the Baijiu model group (p < 0.05), and the high-dose (400 mg / kg) Example group showed a significant decrease in blood ethanol content compared to the control group (p < 0.05). This indicates that the hangover-relief and liver-protecting composition provided by the present invention is significantly more effective in sobering up than the composition described in Example 7 disclosed in CN114668830B.

[0057] Detection comparison experiment 3 (1) 120 specific pathogen-free C57BL / 6J male mice (8 weeks old, 22-25 g) were fed a standard diet for one week and then randomly divided into 6 groups, 20 mice in each group. The 6 groups were: blank control group, alcohol model group, comparative group, and 3 example groups. (2) After 1 week of adaptation to the Lieber-DeCarli control liquid diet (free diet, no water provided), the Example group: from the 1st day to the 14th day, they were first gavaged with 100 mg / kg, 200 mg / kg, and 400 mg / kg of Example 1 every day, and two hours later, they were gavaged with Lieber-DeCarli liquid feed containing 3% alcohol (5 g / kg BW). From the 15th day to the 35th day, they were first gavaged with 100 mg / kg, 200 mg / kg, and 400 mg / kg of Example 1 every day, and two hours later, they were gavaged with Lieber-DeCarli liquid feed containing 5% alcohol (5 g / kg BW). The alcohol model group: from the 1st day to the 14th day, they were first gavaged with the same volume of normal saline as the experimental group, and two hours later, they were gavaged with Lieber-DeCarli liquid feed containing 3% alcohol (5 g / kg BW). The blank control group was first gavaged with an equal volume of saline as that of the experimental group from the 1st day to the 14th day, and then gavaged with a standard Lieber-DeCarli (non-alcoholic) liquid feed two hours later. The blank control group was first gavaged with an equal volume of saline as that of the experimental group from the 1st day to the 14th day, and then gavaged with a standard Lieber-DeCarli (non-alcoholic) liquid feed two hours later. The blank control group was first gavaged with an equal volume of saline as that of the experimental group from the 15th day to the 35th day, and then gavaged with a standard Lieber-DeCarli (non-alcoholic) liquid feed two hours later. Comparative group: From day 1 to day 14, mice were gavaged daily with 400 mg / kg of the comparative alcohol-detoxifying and liver-protecting composition, followed two hours later by gavage with a Lieber-DeCarli liquid diet containing 3% alcohol (5 g / kg BW). From day 15 to day 35, mice were gavaged daily with 400 mg / kg of the comparative alcohol-detoxifying and liver-protecting composition, followed two hours later by gavage with a Lieber-DeCarli liquid diet containing 5% alcohol (5 g / kg BW). Nine hours after the final gavage, mice were euthanized, and blood and liver samples were collected.

[0058] (3) Place the collected blood in a 2 mL centrifuge tube and centrifuge at 1500 g for 10 min at 4°C. Collect the supernatant as serum. Measure the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) in the serum according to the instructions of the commercial kit.

[0059] (4) The levels of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the liver were measured according to the instructions of the commercial enzyme-linked immunosorbent assay (ELISA) kit.

[0060] In this comparative experiment, the comparative example group selected the composition shown in Example 7 disclosed in patent publication document CN114668830B.

[0061] The effects of the alcohol-relieving and liver-protecting composition on the ALT / AST activity and MDA concentration in the serum of mice with chronic liver damage due to alcohol are shown in Table 4: Table 4

[0062] Note: * indicates that the experimental group has a significant difference compared with the liquor model group (p<0.05); # indicates that the experimental group has a significant difference compared with the control group (p<0.05).

[0063] The effects of the alcohol-relieving and liver-protecting composition on the levels of inflammatory factors TNF-α, IL-6, and IL-1β in the liver of mice with chronic liver damage caused by alcohol are shown in Table 5: Table 5

[0064] Note: * indicates that the experimental group has a significant difference compared with the liquor model group (p<0.05); # indicates that the experimental group has a significant difference compared with the control group (p<0.05).

[0065] As shown in Table 4, serum ALT and AST activity, as well as serum MDA concentration, were significantly lower in the medium- and high-dose Example and Comparative Example groups compared to the Baijiu model group (p < 0.05), indicating a significant reduction in liver damage. Table 5 shows that the levels of liver inflammatory factors TNF-α, IL-6, and IL-1β were significantly lower in the Example and Comparative Example groups compared to the Baijiu model group (p < 0.05), and the medium- and high-dose Example groups were significantly lower than the Comparative Example group (p < 0.05). This demonstrates that the alcohol detoxification and liver protection composition provided by the present invention is significantly superior to the composition described in Example 7 disclosed in CN114668830B in terms of its alcohol detoxification and liver protection effects.

[0066] The above-described embodiments only express some of the embodiments of the present invention. The description is relatively specific and detailed, but it should not be understood as limiting the scope of the patent of the present invention. It should be pointed out that for those skilled in the art, it is still possible to modify the technical solutions described in the above-mentioned embodiments or to replace some of the technical features therein with equivalents. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A composition for sobering up and protecting the liver, characterized in that: Calculated by mass, it includes 5-20 parts of kudzu root extract, 5-20 parts of hovenia dulcis fruit extract, 5-20 parts of milk thistle extract, 1-20 parts of turmeric extract, 1-20 parts of gastrodia elata extract, 1-10 parts of ganoderma lucidum extract, 1-20 parts of eucommia leaf extract, 1-10 parts of cornus officinalis extract, 1-30 parts of corn oligopeptide powder, 1-50 parts of maltodextrin, 1-10 parts of microcrystalline cellulose, 1-2 parts of silicon dioxide, and 1-2 parts of magnesium stearate.

2. The alcohol-relieving and liver-protecting composition according to claim 1, characterized in that: It also contains 1-50 parts of sorbitol.

3. The alcohol-relieving and liver-protecting composition according to claim 1, characterized in that: 20 parts of Pueraria root extract, 15 parts of Hovenia dulcis fruit extract, 10 parts of Milk thistle extract, 10 parts of Turmeric extract, 2 parts of Gastrodia elata extract, 2 parts of Ganoderma lucidum extract, 2 parts of Eucommia ulmoides leaf extract, 2 parts of Cornus officinalis extract, 1 part of corn oligopeptide powder, 30 parts of maltodextrin, 4 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 1 part of magnesium stearate.

4. The alcohol-relieving and liver-protecting composition according to claim 1, characterized in that: 10 parts of Pueraria root extract, 15 parts of Hovenia dulcis fruit extract, 5 parts of Milk thistle extract, 5 parts of Turmeric extract, 1 part of Gastrodia elata extract, 1 part of Ganoderma lucidum extract, 1 part of Eucommia ulmoides leaf extract, 1 part of Cornus officinalis extract, 1 part of Cornus officinalis oligopeptide powder, 50 parts of maltodextrin, 8 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 1 part of magnesium stearate.

5. The alcohol-relieving and liver-protecting composition according to claim 1, characterized in that: 20 parts of Pueraria root extract, 20 parts of Hovenia dulcis fruit extract, 20 parts of Milk thistle extract, 20 parts of Turmeric extract, 20 parts of Gastrodia elata extract, 10 parts of Ganoderma lucidum extract, 20 parts of Eucommia ulmoides leaf extract, 10 parts of Cornus officinalis extract, 10 parts of corn oligopeptide powder, 30 parts of maltodextrin, 10 parts of microcrystalline cellulose, 2 parts of silicon dioxide, and 2 parts of magnesium stearate.

6. The alcohol-relieving and liver-protecting composition according to claim 1, characterized in that: 5 parts of Pueraria root extract, 5 parts of Hovenia dulcis fruit extract, 5 parts of Milk thistle extract, 1 part of Turmeric extract, 1 part of Gastrodia elata extract, 1 part of Ganoderma lucidum extract, 1 part of Eucommia ulmoides leaf extract, 1 part of Cornus officinalis extract, 1 part of corn oligopeptide powder, 50 parts of maltodextrin, 10 parts of sorbitol, 10 parts of microcrystalline cellulose, 1 part of silicon dioxide, and 0.5 parts of magnesium stearate.

7. A method for preparing the alcohol-relieving and liver-protecting composition according to any one of claims 1 to 6, characterized in that: The following steps are included: a raw material pulverizing step of pulverizing kudzu root into kudzu root powder, pulverizing hovenia dulcis fruit into hovenia dulcis fruit powder, pulverizing milk thistle into milk thistle powder, pulverizing turmeric into turmeric powder, pulverizing gastrodia elata into gastrodia elata powder, pulverizing ganoderma lucidum into ganoderma lucidum powder, pulverizing eucommia leaf into eucommia leaf powder, and pulverizing cornus officinalis into cornus officinalis powder; In the extraction step, the raw materials are poured into a 70% ethanol solution for extraction, and the extracts are concentrated and spray-dried to obtain Pueraria root extract, Hovenia dulcis fruit extract, Milk thistle extract, Curcuma longa extract, Gastrodia elata extract, Ganoderma lucidum extract, Eucommia ulmoides leaf extract, and Cornus officinalis extract; In the mixing step, kudzu root extract, hovenia dulcis fruit extract, milk thistle extract, turmeric extract, gastrodia elata extract, ganoderma lucidum extract, eucommia leaf extract, cornus officinalis extract, cornus officinalis extract, corn oligopeptide powder, maltodextrin, microcrystalline cellulose, silicon dioxide and magnesium stearate are mixed.

8. The preparation method according to claim 7, characterized in that The method further comprises a tabletting step of pressing the mixture obtained in the mixing step into tablets.

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