The invention discloses a medicine composition for treating chronic nephrosis. The medicine composition is characterized by being prepared from, by weight, emblic leafflower fruits, jasminum grandiflorum, Chinese brake herb, abelmoschus manihot, ligusticum, grifola, abelmoschus manihot, persicaria perfoliata, all-grass of twocolor velvetplant, fiveleaf akebia fruits, pangolin scales, herba epimedii, human placenta, clematis chrysocoma, radish seeds, milkvetch roots, herba eupatorii, semen plantaginis, fruits or seeds of Apple of Peru, paris polyphylla, oldenlandia diffusa, justicia procumbens, loranthus parasiticus, fructus psoraleae, Chinese cinnamon, melanterite, centella asiatica, serissa japonica, arisaema cum bile, giant knot weed, field pennycress, chinaroot greenbrier, diclofenac sodium, dextran, casein phosphopeptides, povidone, menthol, Vitamin D, pantothenic acid, citric acid, Vitamin E, Vitamin K and cellulose. The medicine composition has the effects of clearing away heat and toxic materials, inducing diuresis to reduce edema and warming kidney and excreting dampness.