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Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof

A technology for chronic nephritis and n-butanol, which is applied in the field of medicine, can solve the problems of difficulty in establishing modern quality standards for drug quality, clinical efficacy, unclear effective parts or active ingredients, etc., which is conducive to the establishment of drug quality standards and quality control, and is convenient for development. Clear effect with application, content

Inactive Publication Date: 2012-01-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above application forms, the active substances and ineffective parts of kidney tea are used together, the effective parts or active ingredients are not clear, and it is difficult to establish modern quality standards, effectively control drug quality and ensure clinical efficacy

Method used

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  • Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof
  • Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof
  • Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Screening of effective parts of kidney tea for treating chronic nephritis

[0017] Prepare 4 parts of kidney tea respectively, including chloroform part, n-butanol part, methanol part and water part (for the preparation process, see figure 1 ). according to figure 1 , firstly use the decoction method to extract the concentrated liquid of kidney tea (the ratio of volume to medicinal material weight is 1:1), the concentrated liquid is sequentially extracted 3 times with chloroform and n-butanol according to the volume of 0.4 to 1 times each, and the solvent is evaporated under reduced pressure Afterwards, the chloroform fraction and the n-butanol fraction were obtained respectively; the extracted aqueous solution layer was evaporated to dryness under reduced pressure, then extracted three times with methanol, the methanol extracts were combined, and evaporated to dryness under reduced pressure to obtain the methanol fraction; the remaining part was evapo...

Embodiment 2

[0024] Example 2 Preparation of the n-butanol fraction of kidney tea

[0025] Preparation method: Take kidney tea, add water 25 times the weight of the medicinal materials for the first time, soak at room temperature for 0.75h, decoct in water for 0.5h, filter while hot, add water 10 times the weight of medicinal materials for the second time, decoct in water for 0.5h, and decoct while hot Filtrate, combine the aqueous solutions, concentrate to 1:1 (ml:g), and obtain the water-extracted concentrated solution, extract three times with 1 volume of chloroform, and extract the aqueous solution with 1 volume of n-butanol for three times after chloroform extraction, combine, reduce After recovery of n-butanol by pressure, vacuum drying can obtain the n-butanol part of kidney tea.

[0026] Test results: The yield of the n-butanol part of kidney tea is 1.24%, and the content of phenolic acids in the n-butanol part is 55.76%.

[0027]

Embodiment 3

[0028] Example 3 Preparation of the n-butanol fraction of kidney tea

[0029] Preparation method: take kidney tea, add water 20 times the weight of medicinal materials for the first time, soak at room temperature for 0.5 hours, decoct in water for 0.75 hours, filter while hot, add water 16 times the weight of medicinal materials for the second time, decoct 0.75 times of the weight of medicinal materials, and filter while hot After that, the aqueous solution was combined and concentrated to 1:1 (ml:g) to obtain the water-extracted concentrated solution, which was extracted three times with 0.8 times the volume of chloroform. After recovering the n-butanol, it is vacuum-dried to obtain the n-butanol fraction of kidney tea.

[0030] Test results: The yield of the n-butanol part of kidney tea is 1.41%, and the content of phenolic acids in the n-butanol part is 59.85%.

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Abstract

The invention discloses an Orthosiphon n-butanol fraction medicine for treating chronic nephritis and a preparation method thereof, belonging to the technical field of medicine. The content of phenolic acid in the Orthosiphon n-butanol fraction is 50-60 wt%. The preparation method comprises the following steps: boiling Orthosiphon extraction liquid and carrying out condensation, extracting with chloroform, and then extracting with n-butanol. According to the invention, the active site of treating chronic nephritis by Orthosiphon is the n-butanol fraction, the composition and content of the ingredients are clear; by extraction and purification, ineffective substances for treating chronic nephritis are removed, the dosage is reduced, and patients compliance with medication is increased. Simultaneously, the invention is good for the establishment of drug standard and quality control, and is convenient for development and application of various preparations.

Description

technical field [0001] The invention relates to a medicine in the technical field of medicine and a preparation method thereof, in particular to a kidney tea n-butanol part medicine for chronic nephritis and a preparation method thereof. Background technique [0002] Chronic nephritis is a chronic glomerular disease with multiple etiologies, and its incidence rate is on the rise, ranking first among kidney diseases. The disease has the characteristics of long course, lingering condition, and progressive aggravation, and it is easy to transform into renal failure. More than 60% of chronic renal failure is caused by chronic nephritis. At present, Western medicine still lacks substantial progress in the treatment of this disease. Although classic hormone and / and immunosuppressant treatments have certain curative effects, they often have serious side effects, such as susceptibility to infection, osteoporosis, decreased immune function, and lipid metabolism. Disorders, glucose m...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P13/12
Inventor 邱明丰彭崇胜殷明王泽剑张丽丽
Owner SHANGHAI JIAO TONG UNIV
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