Medicinal composition containing bilobalide B and its preparation process and usage

A technology of ginkgolides and compositions, applied in the field of medicine, to achieve the effects of eliminating platelet aggregation, improving microcirculation, and inhibiting thrombus formation

Active Publication Date: 2006-05-10
弘和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report that after the purification of ginkgolide B and ligustrazine phosphate are combined in a certain ratio, it is made into a drug for clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Dissolve the raw material with 5 times the amount of water, degrease with petroleum ether, extract the aqueous solution 5 times with an equal volume of ethyl acetate, combine the ethyl acetate extracts, wash 4 times with 0.1mol / L sodium bicarbonate solution, wash The final ethyl acetate solution was washed with water to neutrality; the ethyl acetate solution was concentrated, and the concentrated solution was diluted with water to a relative density of 1.05, filtered with an ultrafiltration membrane with a molecular weight cut-off of 200 and 600, and collected solution, concentrated, dried, on C 18 Prepare a chromatographic column in reverse phase, elute with 70% ethanol solution, collect the eluate in equal volume, mix the eluate rich in ginkgolide B, concentrate, and dry to obtain ginkgolide B.

Embodiment 2

[0032] Dissolve the raw material with 5 times the amount of water, degrease with petroleum ether, extract the aqueous solution 5 times with an equal volume of ethyl acetate, combine the ethyl acetate extracts, wash 4 times with 0.1mol / L sodium bicarbonate solution, wash The final ethyl acetate solution was washed with water to neutrality; the ethyl acetate solution was concentrated, and the concentrated solution was diluted with water to a relative density of 1.05, filtered with an ultrafiltration membrane with a molecular weight cut-off of 200 and 600, and collected solution, concentrated, dried, on C 18 Prepare a chromatographic column in reverse phase, elute with 90% ethanol solution, collect the eluate in equal volume, mix the eluate rich in ginkgolide B, concentrate, and dry to obtain ginkgolide B.

Embodiment 3

[0034] Dissolve the raw material with 5 times the amount of water, degrease with petroleum ether, extract the aqueous solution 5 times with an equal volume of ethyl acetate, combine the ethyl acetate extracts, wash 4 times with 0.1mol / L sodium bicarbonate solution, wash The final ethyl acetate solution was washed with water to neutrality; the ethyl acetate solution was concentrated, and the concentrated solution was diluted with water to a relative density of 1.05, filtered with an ultrafiltration membrane with a molecular weight cut-off of 200 and 600, and collected solution, concentrated, dried, on C 18 The chromatographic column was prepared in reverse phase, eluted with 80% ethanol solution, the eluate was collected in equal volume, the eluate rich in ginkgolide B was mixed, concentrated, and dried to obtain ginkgolide B.

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PUM

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Abstract

The invention discloses a medicinal composition containing bilobalide B, which comprises Ligustrazine phosphate and bilobalide B by the weight ratio of 10-500 : 1. the invention also discloses the process for preparing the pharmaceutical composition.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing ginkgolide B and its preparation method and application, more specifically, to a pharmaceutical composition composed of ligustrazine phosphate and ginkgolide B, Its preparation method and its application in the preparation of medicines for treating ischemic cardiovascular and cerebrovascular diseases. Background technique [0002] Ginkgolide is the main active ingredient in Ginkgo biloba, which can eliminate platelet aggregation, inhibit thrombosis, prevent atherosclerosis, and have a good protective effect on myocardial and cerebral ischemia; it mainly contains ginkgolides A and B , C, etc., wherein ginkgolide B is the most active component of its pharmacology. [0003] Ligustrazine phosphate is 2,3,5,6-tetramethylpyrazine phosphate monohydrate (C 8 h 12 N 2 ·H 3 PO 4 ·H 2 O), is white or off-white crystalline powder, has the eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K9/14A61K9/19A61K9/20A61K9/48A61K31/365A61P7/02A61P9/10
Inventor 张玉梅
Owner 弘和制药有限公司
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