10 results about "Tricin" patented technology

The invention discloses an application of wheat flavone in preparation of a medicine for an SRC / MAPK / AP-1 / PD-L1 signal channel inhibitor and an application of the combined action of the wheat flavone and the PD-1 / PD-L1 inhibitor in preparation of a medicine for treating KRAS mutant non-small cell lung cancer. The wheat flavone can make up the deficiency of immunotherapy and enhance the anti-tumor activity of a PD-1 / PD-L1 inhibitor, and has great potential for adjuvant therapy of KRAS mutant non-small cell lung cancer.

The invention provides a quinoa flavone extracting solution as well as a preparation method and application thereof, and belongs to the technical field of natural plant extraction. The preparation method of the quinoa flavone extracting solution provided by the invention comprises the following steps: mixing quinoa, compound enzyme and water to obtain a mixed solution; performing ultrasonic treatment on the mixed solution to obtain a quinoa flavone extracting solution; the compound enzyme comprises cellulase and pectinase. According to the method, the flavone in the chenopodium quinoa willd is extracted by adopting ultrasonic-compound enzyme synergistically, so that the method has the characteristics of high yield, short extraction time, low energy consumption, large raw material treatment capacity, low possibility of damaging active substances, environmental friendliness, reduction of environmental pollution and the like, the comprehensive utilization of the chenopodium quinoa willd can be enhanced, and the additional value of the chenopodium quinoa willd can be improved.

The invention discloses application of two small molecular substances in regulation and control of weed suppression activity of flavonoid glycoside substances. The invention provides any one of the following applications of a GST activator and a GST inhibitor: (A1) regulating the inhibition activity of wheat flavone-5-O-glucoside to weeds; and (A2) the inhibition activity of the isoorientin on weeds is regulated. According to the invention, the weed suppression effect of the flavonoid glycoside substances can be obviously improved, and the use of chemical pesticides is reduced, so that a novel biological control method is provided for agricultural production, and green agriculture and sustainable development can be realized.

The invention relates to the technical field of traditional Chinese medicine, and provides a pharmaceutical composition for regulating intestinal microecological balance and reducing blood sugar, a preparation and application, and the pharmaceutical composition comprises a traditional Chinese medicine effective component composition and a probiotic composition, the traditional Chinese medicine effective component composition comprises balsam pear glycoside, purslane phenolic acid, mulberry leaf alkaloid, corn stigma flavone, buckwheat flavone, moringa oleifera leaf flavone, sophora flower flavone, pollen pini flavone, golden camellia flavone, spirulina platensis phycocyanin, opuntia ficus-indica fruit polyphenol, rhizoma tupistrae chinensis total saponin, valeriana jatamansi volatile oil, cucurbit seven sesquiterpenoids and pholidota nameko unsaturated fatty acid; the probiotic composition comprises lactobacillus gasseri, lactobacillus paracasei, lactobacillus plantarum, lactobacillus bulgaricus and clostridium sporogenes; the pharmaceutical preparation comprises the pharmaceutical composition and auxiliary materials. The invention also discloses application of the pharmaceutical composition in preparation of hypoglycemic drugs. The composition can regulate intestinal micro-ecological balance and improve intestinal health and pancreas islet functions, thereby being beneficial to reducing blood sugar.

The invention relates to the technical field of fermentation engineering and medicines, and discloses a high-yield production method of hispidulin, which comprises the following steps: (1) preparing a nutrient solution, (2) preparing a solid fermentation conversion culture medium, (3) directionally converting solid fermentation, and (4) extracting hispidulin. According to the method, a powerful enzyme system of schizophyllum commune is utilized to perform biotransformation on the traditional Chinese medicine scutellaria baicalensis which is extremely low in homoplantaginin content (or cannot be detected), so that oriented biotransformation of the homoplantaginin of main flavone in scutellaria baicalensis flavone is realized, and high-yield production of the homoplantaginin is realized. The method has the characteristics of high hispidulin directional conversion efficiency, simple operation, cheap raw materials and the like, provides a new technology and a new method for research and development of new hispidulin-containing medicines, functional foods and cosmetics, and has important application prospects and remarkable economic benefits.

The application discloses a flavonoid carbon glycoside compound, a directional separation and preparation method and application thereof. The flavonoid carbon glycoside compound is first extracted and discovered, and is used for preparing a medicine for treating or improving diabetes. The preparation process comprises the following steps: extraction, microporous resin medium pressure chromatography rough separation, reverse phase medium pressure chromatography enrichment, reverse phase preparation column preparation, Fr411 reverse phase preparation liquid chromatography purification, and Fr412 hydrophilic preparation liquid chromatography purification. The flavonoid carbon glycoside compound separated by the application can effectively inhibit alpha-glucosidase activity, has low cost, and has a product purity greater than 95%. The technical means adopted by the application can be used for large-scale production, and is easy to scale. The reverse phase preparation liquid chromatography or the hydrophilic preparation liquid chromatography used in the separation and purification is a rapid isocratic method.

The invention discloses a wheat flavone derivative derived from spartina alterniflora and a preparation method and application thereof. The wheat flavone derivative has a structural expression shown in the specification, the wheat flavone derivative provided by the invention not only can effectively reduce the blood uric acid level, but also can improve metabolic disorders related to hyperuricemia, such as hyperglycemia, hypercholesterol and hypoproteinemia, and has a multi-target effect; .

The invention relates to a preparation method of tricin. In order to overcome the defects that in the prior art, the environment temperature required by the process is low, and industrial production is difficult to achieve, the synthesis method of tricin comprises the steps that 2, 4, 6-trihydroxyacetophenone and a syringaldehyde solution are used as reaction raw materials, proline is used as a catalyst, a flavanone intermediate is prepared through catalytic condensation of an aldol condensation mechanism, and the tricin is synthesized through a one-pot method. The method has the advantages of mild process conditions and simple operation, and is suitable for industrial production.

The invention belongs to the technical field of genetic engineering, and particularly relates to application of a TaUGT gene or an encoding protein thereof in regulating and controlling the content of wheat glycosylated wheat flavone. The invention provides an application of a TaUGT gene or a protein encoded by the TaUGT gene in regulating and controlling the content of wheat glycosylated wheat flavone. The amino acid sequence of the protein encoded by the TaUGT gene is as shown in SEQ ID NO: 2. The invention proves that the TaUGT gene or the encoding protein thereof regulates the content of wheat glycosylated wheat flavonoids, wheat flavonoids can be catalyzed to generate glycosylated wheat flavonoids through overexpression of the TaUGT gene or the encoding protein thereof, particularly wheat flavonoids can be catalyzed to generate Tricin-O-hexoside-O-pentoside through glycosylation, and the content of wheat glycosylated wheat flavonoids is increased.

The invention provides an edible blood product composite modifier, sheep blood tofu and a method, the edible blood product composite modifier comprises a water-retaining agent and an antioxidant, and the water-retaining agent comprises elm bark glue, sa-hao seed glue and konjac glucomannan; the antioxidant comprises buckwheat flavone. According to the invention, a composite modifier composed of natural plant resource water-retaining agents such as elm bark glue, artemisia glue and konjac glucomannan and a natural plant resource antioxidant buckwheat flavone is screened and added into the sheep blood tofu, so that the quality of the sheep blood tofu is well improved, the oxidation discoloration of the sheep blood tofu is effectively inhibited, and the quality of the sheep blood tofu is improved. Moreover, the unfreezing loss rate and the high-temperature sterilization loss rate are respectively reduced by 26.38% and 15.45%, the water retention rate and the yield of the sheep blood tofu are effectively improved, and the honeycomb structure of the sheep blood tofu after unfreezing and high-temperature sterilization can be remarkably improved.