389 results about "Flavonoid glycosides" patented technology

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biochemicals from the activated mast cells, the compositions containg one or more of a flavone or flavonoid glycoside a heavily sulfated, non-bovine proteoglycan, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, a hexosamine sulfate such as D-glucosamine sulfate, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, a long-chain unsaturated fatty acid, a phospholipid, Krill oil, a polyamine, glutiramer acetate and interferon. Certain of the present compositions are useful in protecting against the neuropathological components of multiple sclerosis and similar inflammatory neurological diseases.

The invention discloses a preparation method for fast separating flavonoid glycosides from oil-tea-cakes with a medium pressure column, which comprises the following steps of: decorticating and crushing camellia oleifera abel seeds, degreasing the camellia oleifera abel seeds with non-polar solvents, performing extraction with ethanol water, filtering and condensing the extract to obtain crude extract concrete, performing fast separation with the medium pressure column to obtain an over 90 percent flavonoid glycoside mixture, and further adopting a high performance liquid chromatography to prepare over 95 percent flavonoid glycoside monomers, wherein the flavonoid glycoside monomers are kaemplerol 3-O-[2-O-beta-D-galactose-6-O-alpha-L-rhamnose]-beta-D-glucoside (I) and kaemplerol 3-O-[2-O-beta-D-xylose-6-O-alpha-L-rhamnose]-beta-D-glucoside (II) respectively. The method can be used for batch preparation, and has the advantage of providing quality raw materials for the development of flavonoid glycoside medicaments and healthcare functional products in the oil-tea-cakes.

The invention belongs to the technical field of daily cleaning supplies and in particular relates to gingko handmade soap. The gingko handmade soap comprises the following components in percentage by weight: 70 to 99.5 percent of transparent soap base, 0.05 to 20 percent of gingko extract and 0.05 to 3 percent of essential oil or essence. Compared with the prior art, the gingko handmade soap has the advantages that the gingko extract is added into the handmade soap, and oxygen radicals can be effectively eliminated and growth of melanin can be suppressed through the trace elements such as flavone, zinc, manganese and molybdenum, and flavonoid glycosides and flavonol, so that the skin is cleaned, the effects of whitening the skin, resisting wrinkle and delaying senescence are achieved, and the gingko handmade soap is a natural good item of protecting the skin and beautifying; and moreover, the glycerol which is contained in the handmade soap and is hardly extracted has the effect of deeply moisturizing and has mild characteristics, so that the skin is moist, glossy and high in resilience. In addition, preservatives and other chemical substances are not required to be added into the handmade soap, and the handmade soap is healthy and environment-friendly. In addition, the invention also discloses a method for manufacturing the handmade soap.

The invention discloses a method of extracting flavonoid glycosides from grosvenor monordica leaves and a product thereof. The method comprises the following steps: taking Grosvenor monordica leaves, boiling the Grosvenor monordica leaves with water, carrying out extraction and filtration twice to three times, each extraction lasting 50 to 100 min, combining filtrates, carrying out adsorption on an obtained filtrate by using a macroporous resin, rinsing the resin with water until effluent is colorless, carrying out elution by using ethanol or absolute methanol, collecting eluent, removing ethanol or methanol, placing the eluent in a refrigerator for 20 to 30 h, allowing precipitate to deposit, dissolving the precipitate with absolute ethanol, carrying out filtration and evaporating an obtained filtrate so as to obtain a crude extract, kaempferol-3,7-a-L-dirhamnoside. The extraction method provided in the invention is simple, scientific and reasonable, has strong feasibility and enables an obtained extract product to have a high purity, wherein, the purity of a refined extract product is higher than 95%; the extract product obtained in the invention has good free radical scavenging activity and a wide application prospect. In addition, application of the method enables full utilization of considerable waste grosvenor momordica leaves to be realized, thereby improving the utilization rate of natural resources and reducing waste.

A mulberry leaf extract, a method and use of the same are disclosed in the invention. The mulberry leaf extract obtained by ultrasonication, water extracting and film concentrating contains multiple functional substances of polysaccharide, flavone and flavonoid glycoside, alkaloids, sterols, vitamins, amino acids, and the like, which has abroad application, especially is well applicable to tobacco production industry.

The invention provides a method for comprehensively extracting tea oil, flavonoids compounds, tea saponin and tea polysaccharide. The method comprises the following steps of: extracting the tea oil in a dry oil-tea cake by using a low-polarity solvent, and extracting the oil-tea cake by using ethyl acetate, an ethanol-water solution and water in turn to obtain flavonoid glycosides compounds, the tea saponin and the tea polysaccharide respectively. According to the method for comprehensively extracting the tea oil, the flavonoids compounds, the tea saponin and the tea polysaccharide, provided by the invention, five effective components in the oil-tea cake can be comprehensively extracted in the same process, and the method has the advantages of fewer steps, low toxicity of the solvent and good extracting effect.

The invention provides a real-time release detection method for ginkgo leaf medicinal material. The method comprises the following steps: collecting ginkgo leaf medicinal material in different places of production and different batches; detecting contents of water, extracts and flavonoid glycosides in ginkgo leaves; collecting near-infrared spectroscopic data of ginkgo leaf medicinal material powder; establishing a quantitative analysis model and a real-time release quantitative standard for each quality control index of ginkgo leaves; establishing a qualitative analysis model and a real-time release qualitative standard for quality evaluation of ginkgo leaves. The near-infrared spectroscopic data is introduced into the real-time release detection method for ginkgo leaf medicinal material, the method is used for quickly detecting the contents of water, extracts and flavonoid glycosides in ginkgo leaves and judging whether the quality of the medicinal material is qualified, real-time release detection is performed on the ginkgo leaf medicinal material according to quantitative and qualitative detection results, and only the medicinal material in accordance with both qualitative and quantitative real-time release standards can be released for subsequent production technical process, thus the stability and uniformity of ginkgo leaf preparations in different batches are ensured, and the quality level of the ginkgo leaf preparations is improved.

The present invention belongs to the field of Chinese medicine preparing technology. The ginkgo leaf extract has total flavone and total terpene lactone content over 80 %, total flavone content over 70 %, flavonoid glycoside content over 40 % and total terpene lactone content over 10 %. The extraction process includes the following steps: extracting, purifying and separating, concentration, drying, etc. Compared with available technology, the present invention has the advantages of reasonable technological path, being suitable for industrial production, low production cost, high extracting rate of effective components, etc. The present invention also discloses the infusion liquid and powder for injection with the ginkgo leaf extract and their preparation process. The ginkgo leaf extract has wide application in medicine for treating cardiac vascular diseases.

The invention discloses a method for modifying flavonoid glycoside compounds with galactosy transferase. The flavonoid glycoside compounds are ubiquitous secondary metabolites in the nature and one of main active ingredients of medicinal plant, and have physiological activities of antibacterium, cancer resistance, antioxidation and the like. However, natural flavonoid glycoside compounds frequently have the defects of poor water solubility, poor drug effect and the like. The method solves the defects of relatively low solubility of the natural flavonoid glycoside compounds and takes the natural flavonoid glycoside compounds as a forerunner to improve the water solubility thereof by a glycosylation reaction, thereby improving the bioavailability thereof. The technical essential of the method is as follows: an enzymatic reaction is applied to the synthesis of polyglycoside of flavonoid compounds. Compared with chemical synthesis methods, the method has higher synthesis efficiency and lower cost. After glycosylation modification, part of drugs can improve drug effect and reduce toxic side effect; therefore, the method provides a new approach for the development of new drugs of the flavonoid compounds.

The invention discloses two types of flavonoid glycoside compounds which are kaempferol-3-O-[alpha-L-rhamnopyranosyl-(1-3)-(2'' ', 4'' '-O-diacetyl-alpha-L-rhamnopyranosyl)-(1-6)]-beta-glucopyrose galactopyranoside and kaempferol-3-O-[alpha-L-rhamnopyranosyl-(1-3)-(4'' '-O-acetyl-alpha-L-rhamnopyranosyl)-(1-6)]-beta-D-glucopyrose galactopyranoside respectively. The invention also discloses a method for preparing the two types of flavonoid glycoside compounds. Moreover, pharmacological tests prove that the two types of flavonoid glycoside compounds have quite good effects of reducing blood sugar and blood fat and resisting oxidation and cerebral ischemia, and thus, the flavonoid glycoside compounds of the invention can be used for preparing medicaments, food and cosmetics for preventing and treating diabetes, reducing blood fat and resisting oxidation and cerebral ischemia.

The invention relates to the technical field of traditional Chinese medicine extraction, and relates to a method for extracting flavonoid glycoside compounds in herba epimedii, in particular to a method for extracting flavonoid glycoside compounds in epimedium leaves with a deep eutectic solvent. According to the preparation method, the flavonoid glycoside compounds are extracted from the raw material of herba epimedii with the deep eutectic solvent, particularly a choline deep eutectic solvent, as an extracting agent and water as a diluent for reducing the system viscosity under ultrasonic enhancement. The extraction method has higher extraction efficiency for flavonoid glycoside components, is more thorough in extraction and has the extraction efficiency close to 100%. The method is mildin extraction condition and convenient to operate, has the characteristics of no blast or volatilization of the extracting agent, low loss, low energy consumption and the like and can be applied in efficient and green large-scale production of the flavonoid glycoside compounds and comprehensive utilization of the herba epimedii resource.

The invention discloses an electrostatic spinning method of polyhydroxylated polymer, comprising the following steps of dissolving polyhydroxylated polymer in a solvent to prepares polyhydroxylated polymer solution with mass percent 5% to 10%; adding water-soluble polyol including saponarin, flavonoid glycoside, alkaloid, sterol, diterpene or sesquiterpene compound, and arbutin, sophorolipid or vitamin with mass percent as 5% to 40% of total amount of polyhydroxylated polymer, after uniform agitation, undergoing deaeration treatment to prepare stock solution of electrostatic spinning. Under the condition of the same spinning technique, the speed for producing the stock solution of electrostatic spinning can be 3 to 6 times faster by the method; diameter of the produced fiber is nano-level to sub-micron level with smooth surface and uniform distributed diameter; the quality of product is improved obviously; the method has simple technique without special manufacturing device; therefore, the method is easy for popularization and application.

The invention discloses low-acid ginkgo flavone and an extraction method thereof. The invention is characterized in that the content of the ginkgo flavonoid glycosides of the low-acid ginkgo flavone is over 27 percent, the content of ginkgolides is over 6.5 percent, and the content of ginkgoic acid is lower than 1PPM. The low-acid ginkgo flavone is extracted according to the following method: crushing folium ginkgo, marinating the crushed folium ginkgo in ethanol; recollecting the ethanol used for marinating the crushed folium ginkgo; removing impurities from the marinated folium ginkgo; adding resin to absorb the ginkgoic acid for the first time; eluting with ethanol so as to obtain an eluting solution; adding resin to absorb the ginkgoic acid for the second time; eluting with ethanol so as to obtain an eluting solution; recollecting the ethanol; obtaining the low-acid ginkgo flavone after the drying. Compared with other extraction methods, the extraction efficiency of the low-acid ginkgo flavone extracted through the adoption of the method is improved by 0.2 percent, the content of the ginkgo flavonoid glycosides is improved by 3 percent, the content of the ginkgolides is improved by 0.5 percent and the content of ginkgoic acid is lower than 1PPM.

The invention discloses a jasmine flower extract, a preparation method and an application thereof. The jasmine flower extract contains the following components: 70 percent to 75 percent of jasmine total flavonoids, 15 percent to 20 percent of jasmine non-flavonoid glycosides and 10 percent to 15 percent of jasmine volatile components. A main extraction solvents adopted by the invention when extracting jasmine flower is a mixed solution of ethanol and water in different proportions, and glycoside and aglucon in the flower can also be extracted; polyamide resin column is used for enriching total flavonoids so that impurities are removed and purity is increased; additionally, the method removes a plurality of jasmine fragrant ingredients, and the main effective components of the extract obtained is total flavonoids, the purity is high and the content of jasmine fragrant ingredients is greatly decreased. Pharmacology examination proves that, the extract has the functions of relaxing isolated vascular tissue, removing isolated oxygen free radical, reducing animal blood pressure, relieving myocardial ischemia, improving arrhythmia symptoms and anoxia test and can be applied to treating cardiovascular diseases.

The invention discloses a method for preparing a flavonoid glycoside and stibene glucoside type compound by separating from fenugreek. By virtue of a high-speed countercurrent chromatography (HSCCC) separation technology, isomerides such as vitexin and isovitexin and stibene glucoside type compounds such as rhaponticin, deoxyrhapontin and rhapontigenin which have the similar polarity to that of the isomerides in the fenugreek are subjected to separation preparation, so that the separation time is effectively shortened, and the shortcomings of complicated operation, sample die-adsorption loss, low yield and the like of the conventional preparation method are overcome. According to the method, the technology is simple, the reproducibility is high, and the separation efficiency is high; the obtained monomer content is higher than 96.0 percent and can meet the requirements of a type of botanical drugs and standard contrasts; and the method is suitable for industrial production of medical medicines, standard substances, health protection food, health protection medicines and the like.

A method of producing a flavonoid aglycone concentrate from plant material containing a suitable flavonoid glycoside and / or conjugate thereof comprising the steps of: (i) enzymatically converting the flavonoid glycoside or conjugate thereof into the flavonoid aglycone; and (ii) adjusting the pH to render the flavonoid aglycone relatively insoluble and forming a concentrate containing the same.

The invention discloses a method for quickly preparing flavonoid glycoside from oil-tea meal. The method comprises the following steps of firstly obtaining total flavonoid crude extracts from the oil-tea meal through ethanol extraction, performing enrichment and purification operation by utilization of macroporous adsorption resin, performing low pressure column chromatography refinement, and separating flavonoid glycoside monomers from the oil-tea meal. The method disclosed by the invention has the advantages that large precision equipment is unnecessary, the operation steps are simple and easily mastered, and the effects of simplicity, strong stability, strong repeatability, high yield and low loss of effective components are achieved; active components, namely flavonoid monomers, can be effectively separated from the oil-tea meal, and an important evidence is provided for further scale-up experiment and industrialized production, and excellent raw materials are provided for the development of flavonoid glycoside drugs and healthcare products from the oil-tea meal.

The invention provides a preparation method of flavonoid glycosides in scutellaria baicalensis. The method is suitable for quickly preparing four flavonoid glycosides comprising baicalin, wogonoside, chrysin-6-C-alpha-L-Arabic glucoside-8-C-beta-D-glucoside and oroxylinA-7-O-glucuronide. The preparation method comprises the following steps of: pulverizing scutellaria baicalensis and then adding water to extract; sequentially carrying out alcohol precipitation and high-speed centrifugation; after membrane separation, loading nonpolar macroporous absorption resin and eluting by alcohol / water; collecting eluent and concentrating and drying to obtain a scutellaria baicalensis macroporous resin component; and obtaining a scutellaria baicalensis effective component through parallel preparing liquid-phase chromatographic separation by using acetonitrile water as a flow phase. The preparation method has good selectivity and high purity of the obtained compound and greatly improves the separation and purification efficiency. The preparation process has high repeatability and good maneuverability, is easy to realize standardization and industrialization and has certain guidance effects on quickly obtaining flavones active constituents in the scutellaria baicalensis.

The invention discovers that metal ions can catalyze and hydrolyze natural nucleoside compound and discloses a method for catalyzing and hydrolyzing polysaccharide-base nucleoside compound (saponins and flavonoid glycosides) by metal ions. The method can completely and partially remove polysaccharide base of the nucleoside compound to convert and generate secondary low-sugar base glycoside or genin. Catalyzed and hydrolyzed metal ions can be reused and have low preparation cost; the whole preparation process is simple and safe to operate. The invention is suitable to produce in a large scale and has small damage to saponin and no pollution. The product can be widely applied to develop clinical medicine, health care products, cosmetics and food additives.

A method for extracting and purifying a flavonoid glycoside monomer from a sensitive plant belongs to the technical field of Chinese traditional medicine. The technical scheme is as following: taking the sensitive plant as a raw material; performing ultrasonic extraction and concentration, and then performing alcohol precipitation to remove impurities and reconcentration; separating and enriching by macroporous resin column chromatography, and then separating by combing a gel resin column chromatography technology and a silica gel column chromatography technology to obtain three monomeric compounds including vitexin, orientin and isoorientin, wherein, the three monomeric compounds have the extraction yield of 1.12%, 2.62% and 2.21% respectively, and the purity of the three is above 95%. The method has the advantages of convenient operation, low cost, high purity, high yield, repetitive recycle of the macroporous resin and the solvent, disuse of toxic solvents in the process, no environmental pollution, easy industrialized production and the like.

The invention provides a method for simultaneously extracting Australian tea tree essential oil and flavonoid glycosides. The method is characterized by comprising the following steps: adding an entrainer into the dried Australian tea tree raw materials, performing carbon dioxide supercritical fluid extraction, and performing three-stage separation to obtain the Australian tea tree flavonoid glycosides and Australian tea tree essential oil. The extraction pressure and temperature are reduced, the extraction time is shortened, the method is easy to operate, the Australian tea tree essential oil can be recycled, and the essential oil and flavonoid glycosides yield is improved, so that the production cost is greatly reduced. The method has the characteristics of short production cycle, high product yield, high active ingredient content and wide technical adaptability.

The present invention relates to a process for isolating plant Argyrobium roseum extract that contains flavonoid glycoside, wherein the extract possesses hypoglycaemic activity. The present invention also contemplates a composition containing the extract and a method of treating various hyperglycaemic conditions including non-insulin dependent diabetes mellitus disease condition by administering the extract.

The invention belongs to the technology field of processing and utilization of agriculture product, and relates to a comprehensive extracting method of tea saponin, tea seed flavonoid glycoside, and tea polysaccharide. The method comprises following steps: (1) grinding raw materials; (2) extracting; (3) adjusting acidity; (4) preparing a tea polysaccharide product with a macro-porous resin; (5) preparing tea seed flavonoid glycoside; (6) preparing tea saponin. The method is capable of simultaneously extracting three effective components of tea saponin, tea seed flavonoid glycoside, and tea polysaccharide, and improves the quality of crude tea saponin; adopts an instant extracting technology, has the characteristics of rapidness, completeness, and high efficiency; adopts a macro-porous resin to purify tea saponin, has the advantages of simple technology, low production cost, and high product purity; furthermore, organic solvents are not used during the whole production process , and thus the method is environment-friendly.

The invention relates to an extract method of Chinese traditional medicinal compound rhizoma coptidis alexipharmic soup active part and an application of the active part in preparing medicament resisting vascular dementia. The extract method disclosed by the invention adopts industrialized separating and refining technologies, such as microporous membrane and macroporous resin absorption, greatly decreases cream yield of the preparation, maximally retains effective components, improves transforming rate of effective components in raw materials and purity of effective components in the preparation. The extracted active part comprises three kinds of known chemical components: alkaloids, flavonoid glycosides and iridoid glycosides respectively, and has a vascular dementia resisting function.

The invention relates to an oral enteric-coated preparation of total flavonoids of herba epimedii and an application thereof, belonging to the technical field of medicines. The oral enteric-coated preparation is an enteric capsule, an enteric pill or an enteric tablet and the like capable of being orally taken, which can be prepared from total flavonoids of herba epimedii, hydrolytic enzyme, a biological adhesion agent and other common auxiliary materials in pharmaceutics. According to a bionic enzymolysis oral administration system of the total flavonoids of herba epimedii developed by the technical scheme, the total flavonoids of herba epimedii can be subjected to complete enzymolysis to form a secondary glycoside or aglycone form before intestinal emptying under an in-vivo intestinal environment (37 DEG C and pH 5.2-7.4); the retention time of the administration system on the intestinal absorption site is prolonged by adding the biological adhesion agent, and thus 'real-time enzymolysis and real-time absorption' of medicines are achieved, full enzymolysis of herba epimedii flavonoid glycoside can be further guaranteed, the bioavailability is improved, and more effective and more stable treatment means are provided for osteoporosis and the like.

The invention relates to a method for separating and purifying three flavonoid glycosides from trichosanthes bark. According to the method, three high-purity flavonoid glycosides, namely quercetin-3-O-beta-rutinoside, apigenin-7-O-beta-glucoside and diosmetin-7-O-beta-glucoside, are obtained from the trichosanthes bark through the following steps of: (1) preparing a crude trichosanthes bark extract; (2) extracting; (3) carrying out crude separation by using a polyamide column; and (4) carrying out separation and purification by using semi-preparative high-performance liquid chromatography: carrying out separation and purification on total flavonoid glycosides of the trichosanthes bark by using the semi-preparative high-performance liquid chromatography, wherein the mobile phase is methanol-water. The method disclosed by the invention has the advantages that the process flow is environment-friendly, the damage to the environment is not serious, and the comprehensive cost is low.

The invention relates to a preparation method for instant kudzuvine root milk tea powder, and belongs to the field of further processing of agricultural products. The milk tea powder is prepared through the steps of swelling of kudzuvine root powder in cold water, enzymolysis by amylolytic enzyme in a middle high temperature, allocating, homogenizing, vacuum drying, and smashing. The kudzuvine root milk tea powder not only has the characteristics of mellow, soft, and fresh flavor of the conventional milk tea, but also has various components of soybean flavonoid glycoside, puerarin, a peanut element, and the like, which are beneficial for human health, contained by the kudzuvine root powder, so that the kudzuvine root milk tea powder not only is rich in nutrition, and good in scent and taste, but also has functions of health and health protection; the preparation method for the instant kudzuvine root milk tea powder is scientific and reasonable in process design, and can improve comprehensive utilization value and economic benefit of kudzuvine root resource.

The invention discloses a method for preparing hyperin from Dogbane leaves, which comprises the following steps: firstly. determining the optimum extraction temperature, a separation material and the concentration of an eluting agent; secondly, regulating the pH value, and extracting with a solvent having high hyperin dissolving and extracting power, thus obtaining a liquid extract; thirdly, heating at 80-85 DEG C under reflux of ethanol or methanol, and extracting; and finally, standing and crystallizing at a preferable cooling temperature, thus effectively separating the hyperin and isoquercitrin which are two flavonoid glycoside components having similar properties. In the invention, the hyperin is further purified by preparing a liquid phase; and a moving phase is examined and determined by methodology, and is subjected to targeted and efficient separation and purification based on the absorption wavelength of the hyperin, thus obtaining the hyperin having purity up to 90-99%. Thehyperin conforms to the requirements for Class A active pharmaceutical ingredients.