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Oral enteric-coated preparation of total flavonoids of herba epimedii and application thereof

An enteric-coated preparation and technology of total flavonoids, which are applied in the field of medicine, can solve the problem of low oral bioavailability of total flavonoids of Epimedium, and achieve the effects of improving bioavailability, maintaining stability and prolonging residence time.

Active Publication Date: 2014-11-05
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an oral enteric-coated preparation of total flavonoids of Epimedium, which can realize real-time enzymolysis and absorption of total flavonoids of Epimedium in the intestinal tract, prolong the residence time of the drug at the intestinal absorption site, and ensure the Sufficient enzymatic hydrolysis and absorption to improve the defects of low oral bioavailability of total flavonoids of Epimedium

Method used

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  • Oral enteric-coated preparation of total flavonoids of herba epimedii and application thereof
  • Oral enteric-coated preparation of total flavonoids of herba epimedii and application thereof
  • Oral enteric-coated preparation of total flavonoids of herba epimedii and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Weigh 42.0 g of Epimedium total flavonoids powder, 8.4×10 β-glucosidase 4 U (42.0 g), 10.0 g of hydroxypropyl methylcellulose, and 6.8 g of chitosan, mix well, add an appropriate amount of 95% ethanol as a wetting agent, and make a soft material (to form a ball when held, and to disperse when touched) , sieved and granulated, dried, granulated, added an appropriate amount of magnesium stearate, mixed evenly, compressed into tablets, coated, and made into oral enteric-coated tablets of total flavonoids of Epimedium. The bioavailability of the prepared enteric-coated tablet is 0.52 times higher than that of the total flavonoids powder of Epimedium.

Embodiment 2

[0048] Weigh 42.0 g of Epimedium total flavonoids powder, naringinase 4.2×10 5 U (42.0 g), 15.0 g of low-substituted hydroxypropyl cellulose, 6.0 g of carbomer, and 12.6 g of microcrystalline cellulose, mixed evenly, added an appropriate amount of 95% ethanol as a wetting agent, coated, dried, and prepared Oral enteric-coated pills of total flavonoids of Epimedium. The bioavailability of the prepared enteric-coated pills is 0.88 times higher than that of the total flavonoids powder of Epimedium.

Embodiment 3

[0050] Weigh 42.0 g of Epimedium total flavonoids powder, 3.36×10 cellulase 7 U (84.0 g), hydroxypropyl methylcellulose 16.0 g, carbomer 4.6 g, bletilla striata gum 4.6 g, α-lactose 16.8 g, mix well, add appropriate amount of 95% ethanol as wetting agent, sieve and granulate , dried, whole grains, packed into enteric-coated capsules. The bioavailability of the prepared enteric-coated capsules was 1.13 times higher than that of the total flavonoids powder of Epimedium.

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Abstract

The invention relates to an oral enteric-coated preparation of total flavonoids of herba epimedii and an application thereof, belonging to the technical field of medicines. The oral enteric-coated preparation is an enteric capsule, an enteric pill or an enteric tablet and the like capable of being orally taken, which can be prepared from total flavonoids of herba epimedii, hydrolytic enzyme, a biological adhesion agent and other common auxiliary materials in pharmaceutics. According to a bionic enzymolysis oral administration system of the total flavonoids of herba epimedii developed by the technical scheme, the total flavonoids of herba epimedii can be subjected to complete enzymolysis to form a secondary glycoside or aglycone form before intestinal emptying under an in-vivo intestinal environment (37 DEG C and pH 5.2-7.4); the retention time of the administration system on the intestinal absorption site is prolonged by adding the biological adhesion agent, and thus 'real-time enzymolysis and real-time absorption' of medicines are achieved, full enzymolysis of herba epimedii flavonoid glycoside can be further guaranteed, the bioavailability is improved, and more effective and more stable treatment means are provided for osteoporosis and the like.

Description

technical field [0001] The invention relates to an oral enteric-coated preparation of total flavonoids of Epimedium, which is prepared by preparing total flavonoids of Epimedium, hydrolytic enzymes, bioadhesives and auxiliary materials commonly used in pharmacy into enteric-coated capsules, enteric-coated pills or enteric-coated preparations. The invention also relates to the application of the oral enteric-coated preparation, which belongs to the technical field of medicine. Background technique [0002] Epimedium, as a traditional kidney tonifying Chinese medicine, has been used for thousands of years among the people. It has the functions of tonifying kidney yang, strengthening muscles and bones, and dispelling rheumatism. [0003] Epimedium contains a variety of flavonoids, of which 8-isopentenyl substituted flavone glycosides are the main representative active flavonoids, mainly including icariin, epimedin A, epimedin B, epimedin C and Baohuoside I etc. (see structure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61K47/42A61K9/00A61K9/20A61K9/48A61P19/10
Inventor 陈彦高霞王莹
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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