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Extraction method of coptis detoxifcation decoction active site and use thereof

A technology of Huanglian Jiedu Decoction and active parts, which is applied in the field of extraction of active parts of traditional Chinese medicine compound, can solve the problems that the quality and technological content of compound preparations need to be improved urgently, and achieve the effects of shortening production time, improving transfer rate, and reducing production costs

Active Publication Date: 2009-06-17
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Huanglian Jiedu Decoction, as a classic prescription for clearing heat and detoxifying, has been used clinically at home and abroad to treat sequelae of cerebrovascular disorders, but the quality and technological content of this compound preparation still need to be improved urgently

Method used

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  • Extraction method of coptis detoxifcation decoction active site and use thereof
  • Extraction method of coptis detoxifcation decoction active site and use thereof
  • Extraction method of coptis detoxifcation decoction active site and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of Huanglian Jiedu Decoction Capsules

[0027] Take Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, and Gardenia, feed 6000 grams according to the mass ratio of 9:6:6:9, mix well, add water to decoct twice, add 60 liters of water for the first time, decoct for 1.5 hours, and add water 48 for the second time. liter, decoct for 1.5 hours, filter, and merge the decoction liquid twice; put it into a tubular centrifuge after cooling to room temperature, separate at a high speed at a speed of 6000r / min, take the liquid medicine, and collect the precipitate I for subsequent use; centrifuge the obtained medicine Liquid over 0.2μm Al 2 o 3 Microfiltrate the ceramic membrane to collect the microfiltrate; the microfiltrate is placed on an AB-8 macroporous adsorption resin column, the amount of resin is 2.5 times the amount of the medicinal material, and after washing with 6 times the volume of the column with distilled water, wash with e...

Embodiment 2

[0029] Embodiment 2: the preparation method of Huanglianjiedu decoction tablet

[0030] Take Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendri, and Gardenia, feed 6000 grams according to the weight ratio of 9:6:6:9, mix well, add water to decoct twice, add 60 liters of water for the first time, decoct for 1.5 hours, and add water 48 for the second time. liter, decoct for 1.5 hours, filter, and merge the decoction liquid twice; put it into a tubular centrifuge after cooling to room temperature, separate at a high speed at a speed of 6000r / min, take the liquid medicine, and collect the precipitate I for subsequent use; centrifuge the obtained medicine Liquid over 0.2μm Al 2 o 3Ceramic membrane is subjected to microfiltration, and the microfiltrate is collected; the microfiltrate is put on an AB-8 macroporous adsorption resin column, and the amount of resin is 2.5 times that of medicinal materials, and after washing with 6 times the column volume of distilled water,...

Embodiment 3

[0032] Embodiment 3: the preparation method of Huanglian Jiedu Decoction Granules

[0033] Take Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, and Gardenia, feed 6000 grams according to the mass ratio of 9:6:6:9, mix well, add water to decoct 3 times, add 60 liters of water for the first time, decoct for 1.5 hours, second and third Add 48 liters of water each time, decoct for 1.5 hours each time, filter, and merge the decoction liquid for three times; put it into a tubular centrifuge after cooling to room temperature, separate at a high speed at a speed of 6000r / min, get the medicinal liquid, and collect the precipitate 1 simultaneously. Standby; the drug solution obtained by centrifugation was passed through 0.2 μm Al 2 o 3 Ceramic membrane is subjected to microfiltration to obtain microfiltrate; the microfiltrate is placed on an AB-8 macroporous adsorption resin column, the amount of resin is 2.5 times the amount of medicinal materials, and after washing w...

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Abstract

The invention relates to an extract method of Chinese traditional medicinal compound rhizoma coptidis alexipharmic soup active part and an application of the active part in preparing medicament resisting vascular dementia. The extract method disclosed by the invention adopts industrialized separating and refining technologies, such as microporous membrane and macroporous resin absorption, greatly decreases cream yield of the preparation, maximally retains effective components, improves transforming rate of effective components in raw materials and purity of effective components in the preparation. The extracted active part comprises three kinds of known chemical components: alkaloids, flavonoid glycosides and iridoid glycosides respectively, and has a vascular dementia resisting function.

Description

1. Technical field [0001] The invention relates to a method for extracting the active part of the Chinese medicine compound Huanglianjiedu decoction and its application in the preparation of anti-vascular dementia drugs, and belongs to the technical field of the extraction method for the active part of the Chinese medicine compound. 2. Background technology [0002] With the aging of the world's population, Alzheimer's disease has become one of the main diseases that threaten the elderly's later life, and research has an important role in the treatment of this disease. Alzheimer's disease is divided into two categories: vascular dementia (vasculardisease, VD) and senile dementia (alzheimer disease, AD). [0003] In order to find drugs for the treatment of senile dementia, scholars all over the world are trying to find new anti-senile dementia drugs and new treatment methods. At present, there are a variety of therapeutic drugs, such as acetylcholinesterase inhibitor tacrine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P25/28
Inventor 朱华旭潘林梅付廷明黄山唐于平郭立玮
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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