Method for modifying flavonoid glycoside compounds with galactosy transferase

A technology of flavonoids and compounds, applied in the field of biopharmaceuticals, can solve the problems of low solubility of natural flavonoid glycoside compounds, achieve the effects of improving bioavailability, easy acquisition, and improving water solubility
CN101575631AInactive Publication Date: 2009-11-11NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2009-11-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for modifying flavonoid glycoside compounds with galactosy transferase. The flavonoid glycoside compounds are ubiquitous secondary metabolites in the nature and one of main active ingredients of medicinal plant, and have physiological activities of antibacterium, cancer resistance, antioxidation and the like. However, natural flavonoid glycoside compounds frequently have the defects of poor water solubility, poor drug effect and the like. The method solves the defects of relatively low solubility of the natural flavonoid glycoside compounds and takes the natural flavonoid glycoside compounds as a forerunner to improve the water solubility thereof by a glycosylation reaction, thereby improving the bioavailability thereof. The technical essential of the method is as follows: an enzymatic reaction is applied to the synthesis of polyglycoside of flavonoid compounds. Compared with chemical synthesis methods, the method has higher synthesis efficiency and lower cost. After glycosylation modification, part of drugs can improve drug effect and reduce toxic side effect; therefore, the method provides a new approach for the development of new drugs of the flavonoid compounds.
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Description

【Technical field】:

[0001] The invention belongs to the technical field of biopharmaceuticals. It specifically relates to a method for modifying flavonoid glycosides by using galactosyltransferase. This method is based on the natural active lead of flavonoid glycosides, and by analyzing the relationship between its chemical structure and biological activity, the glycosides of flavonoids are glycosides. Kylation modification is one of the effective ways to develop new drugs. 【Background technique】:

[0002] Flavonoids, also known as bioflavonoids or plant flavonoids, are a large class of phenolic substances that exist in nature. Yellow in color and known as bioflavonoids.

[0003] Flavonoids are a class of substances with 2-phenylchromone as the mother nucleus. Two aromatic rings (A ring, B ring) are connected by a three-carbon chain, with a C6-C3-C6 basic configuration. The three rings are labeled A, B, and C, respectively.

[0004]

[0005] Basic structure of flavonoi...

Claims

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