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Ginkgo medicine composition, its preparing method and its use

A composition and drug technology, applied in the field of preparation of drugs for the treatment of ischemic cardiovascular and cerebrovascular diseases, to achieve the effects of reducing myocardial oxygen consumption, preventing thrombus formation, and improving blood flow characteristics

Active Publication Date: 2005-05-18
弘和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But at present, there is no report on the preparation of medicines for clinical use after combining ginkgo leaf extract and ligustrazine phosphate in a certain ratio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] After 5000g of ginkgo leaves are crushed, add 12 times the amount of 70% ethanol, and extract twice at 50°C under reflux for 3 hours each time, combine the extracts, filter, concentrate under reduced pressure to 1 / 10 of the volume of the extract, and add an equal amount of concentrated solution of water , adding 1% concentrated liquid amount of sodium zeolite filter aid to filter, the filtrate is adsorbed with D101 type macroporous resin, then desorbed with 70% ethanol solution of 2 times the amount of macroporous resin, and the desorbed solution is concentrated to dryness under reduced pressure to obtain 150g containing The ginkgo leaf extract of total flavonoids (containing 25% of total flavonoids) is ready for use.

[0034] Take by weighing Ginkgo biloba extract 16g (containing total flavonoids 4g), ligustrazine phosphate (C 8 h 12 N 2 ·H 3 PO 4 ·H 2(2) 40g, can be made into 100000ml liquid medicine, finally make 400 bottles of large-capacity injections (the spe...

Embodiment 2

[0036] After crushing 5000g of ginkgo leaves, add 10 times the amount of 65% ethanol, and extract twice at 45°C under reflux for 4 hours each time, combine the extracts, filter, concentrate under reduced pressure to 1 / 8 of the volume of the extract, and add 1.5 times the amount of concentrated solution water, add 2% concentrated liquid amount of talcum powder filter aid to filter, the filtrate is adsorbed with macroporous resin (such as HP-20 type resin), desorbed with 72% ethanol solution of 3 times the amount of macroporous resin, and the desorbed solution is concentrated under reduced pressure To dry, get the ginkgo leaf extract that 150g contains total flavonoids (containing total flavonoids 25%) for subsequent use.

[0037] Take by weighing Ginkgo biloba extract 8g (containing total flavonoids 2g), ligustrazine phosphate (C 8 h 12 N 2 ·H 3 PO 4 ·H 2 (0) 50g, can be made into 2000ml liquid medicine, finally made into 1000 small volume injections. Add an appropriate a...

Embodiment 3

[0039] After crushing 5000g of ginkgo leaves, add 10 times the amount of 70% ethanol, and extract twice at 50°C under reflux for 3 hours each time, combine the extracts, filter, concentrate under reduced pressure to 1 / 9 of the volume of the extract, add 2 times the amount of concentrated water , add the talcum powder filter aid of 1.5% concentrated liquid amount to filter, the filtrate is adsorbed with macroporous resin (such as D101 type resin), desorbs with the 70% ethanol solution of 2 times the amount of macroporous resin, desorbs and concentrates to dryness under reduced pressure, Obtain 150g of Ginkgo biloba extract containing total flavonoids (containing 25% of total flavonoids) for subsequent use.

[0040] Take by weighing Ginkgo biloba extract 8g (containing total flavonoids 2g), ligustrazine phosphate (C 8 h 12 N 2 ·H 3 PO 4 ·H 2 (2) 200g, can be made into 1000ml liquid medicine, finally made into 1000 small volume injections. Add an appropriate amount of water...

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PUM

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Abstract

The gingko medicine composition consists of gingko leaf extract and ligustrazine phosphate in the amount of 1-100 times of gingko leaf extract. The preparation process of the medicine composition is also disclosed. As the compound preparation, the medicine composition of the present invention has the complementary and synergistic effects of gingko leaf extract and ligustrazine phosphate, including promoting blood circulation to disperse blood clots, resisting platelet aggregation, dilating blood vessel and improving microcirculation, and may be used in preparing medicine for ischemic cardiac and cerebral vascular diseases.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition, its preparation method and application thereof, specifically, relate to a kind of pharmaceutical composition composed of ligustrazine phosphate and ginkgo leaf extract extracted from ginkgo biloba, its preparation method and Its application in the preparation of medicines for treating ischemic cardiovascular and cerebrovascular diseases. Background technique [0002] Ginkgo biloba extract contains active ingredients such as total flavonoids and total lactones, and total flavonoids are the main active ingredients of Ginkgo biloba extract. The content of total flavonoids in Ginkgo biloba leaves is 0.5% to 1% (W / W), mainly in the form of glycosides, and the main aglycones are quercetin, kaempferol and isorhamnetin. Ginkgo biloba total flavonoids contained in Ginkgo biloba extract can expand coronary vessels, cerebral blood vessels, promote blood circulation and remove blood stasis, an...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K9/20A61K9/48A61P9/10A61P9/14
Inventor 王建辉
Owner 弘和制药有限公司
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