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Method for preparing tetramethyl pyrazine

A kind of technology of tetramethylpyrazine and tetramethyldihydropyrazine, which is applied in the field of chemical synthesis of tetramethylpyrazine and achieves the effect of high purity

Active Publication Date: 2004-11-17
LI MIN PHARM FAB OF LIVZON PHARM GRP
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  • Abstract
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Problems solved by technology

Although there are different problems depending on the specific reduction steps and methods used, the most important thing is the source of the raw material 2,3-butanedione monoxime

Method used

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  • Method for preparing tetramethyl pyrazine
  • Method for preparing tetramethyl pyrazine
  • Method for preparing tetramethyl pyrazine

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Embodiment Construction

[0034] The present invention adopts methyl ethyl ketone chlorination method to prepare ligustrazine, and this production technology gets rid of the drawback of general methyl ethyl ketone oximation method. In the methyl ethyl ketone oximation method, it is required to prepare highly toxic gas nitrosoethyl ester. Among them, nitrosoethyl ester is generated by reacting concentrated sulfuric acid with sodium nitrite to generate nitrous acid gas, which is then generated by reacting with ethanol.

[0035] In the present invention, especially apply following reaction or course of action:

[0036]

[0037] The invention relates first to the preparation of tetramethylpyrazine by condensation reaction using aminobutanone. Specifically, aminobutanone is 3-aminobutanone. A compound with a ring structure is formed by the condensation reaction between molecules of 3-aminobutanone, and steam is introduced into it to produce tetramethylpyrazine. Because atomic oxygen, ie [O], is genera...

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Abstract

The invention provides a process for chemically synthesizing tetramethylpyrazine by using amino butanone as raw material and letting in steam at the presence of alkalinity, wherein the obtained tetramethylpyrazine is in the form of trihydrate. The synthesis process can be applied to the field of pharmacy. The invention also provides the process for preparing phosphoric ligustrazine and phosphoric ligustrazine by using tetramethylpyrazine.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a chemical synthesis method of tetramethylpyrazine. Background technique [0002] The English name of tetramethylpyrazine is tetramethylpryazine, the English abbreviation is TMPZ or TMP, and the chemical name is 2,3,5,6-tetramethylpyrazine. It was first extracted from the traditional Chinese medicine Chuanxiong, rhizome of curcuma, and stem of ventilated hemp tree, so it is also called ligustrazine. The molecular structural formula of tetramethylpyrazine is as follows: [0003] [0004] Pharmacological studies have proved that its hydrochloride and phosphate both have the effect of anti-platelet aggregation, and have good effects on various diseases and symptoms. Relatively speaking, the absorption of ligustrazine phosphate in the body is more regular and safer than that of ligustrazine hydrochloride. Therefore, ligustrazine phosphate is often used as the active ingredient i...

Claims

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Application Information

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IPC IPC(8): C07D241/12
Inventor 邓泽庭陶德胜罗荣邓钦鹏
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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