37 results about "Asymmetric induction" patented technology

A process for producing an optically active isomer of a compound represented by the formula (II) (wherein ring A represents an optionally substituted benzene ring; R<1> represents hydrogen, an optionally substituted hydrocarbon group, acyl, or acyloxy; R<2>, R<3>, and R<4> each represents hydrogen, optionally substituted alkyl, optionally substituted alkoxy, or optionally substituted amino; X represents nitrogen or CH; Y represents nitrogen or CH; and * indicates an asymmetric center) or of a salt of the compound, characterized by reacting a compound represented by the formula (I) (wherein the symbols have the same meanings as the above) or a salt thereof with an excess of an oxidizing agent in the presence of a catalyst for asymmetry induction. This process is a simple process by which an optically active sulfoxide derivative can be efficiently and industrially mass-produced in high yield while attaining an extremely high enantiomer excess.

A method of determining an overlay error. Measuring an overlay target having process-induced asymmetry. Constructing a model of the target. Modifying the model, e.g., by moving one of the structures to compensate for the asymmetry. Calculating an asymmetry-induced overlay error using the modified model. Determining an overlay error in a production target by subtracting the asymmetry-induced overlay error from a measured overlay error. In one example, the model is modified by varying asymmetry p(n′), p(n″) and the calculating an asymmetry-induced overlay error is repeated for a plurality of scatterometer measurement recipes and the step of determining an overlay error in a production target uses the calculated asymmetry-induced overlay errors to select an optimum scatterometer measurement recipe used to measure the production target.

The invention relates to the field of chemical catalysis, and discloses a kind of phosphoramidite ligand, its preparation method and application. The synthesized phosphoramidite ligands and their enantiomers or their racemates use biphenyl as the backbone, and undergo a central chiral asymmetric induction reaction to achieve complete central chirality to axial chirality transfer. The synthesis method of the phosphoramidite ligand and its enantiomer or its raceme is simple and economical, and the common and complicated chiral resolution process is avoided when preparing the chiral ligand. The present invention uses phosphoramidite ligands and their enantiomers or their racemates to form complexes with active metal iridium to catalyze the asymmetric addition reaction of N-protected isatin and arylboronic acid, and obtains a good catalytic effect. The product can be obtained in a yield of more than 96% and an enantiomeric excess (ee) value of more than 92%.

The invention discloses a chiral double reaction center ruthenium catalyst as well as its synthesis and application. The chiral double-reaction center ruthenium catalyst provided by the present invention is not only easy to synthesize, but also the double-reaction center ruthenium catalyst it has can be efficiently applied to the asymmetric catalytic hydrogenation of β-aminoketone compounds; finally, 100% conversion can be obtained rate and more than 99.9% asymmetry induction effect. The synthesis operation of the catalyst described in the invention is simple and convenient, the selectivity and yield are high, the catalyst has good atom economy and good industrial application prospect.

Provided is a nanostructured polyphase biomimetic catalyst of quinine and a process for preparing same, belonging to the catalytic field of preparing technology of biomimetic catalyst. The method for preparation of the novel catalyst is that mesoporous material with a nanometer-sized bore diameter is employed to be a vector, a functional group provided by the vector is employed to be a first platform and reacts with substance which has active primitives, and further a second reactive platform is provided and is assembled in situ inside a nanostructured space, thereby forming the objective catalyst. The catalyst has the characteristics that active components are assembled via high dispersion in a one-dimensional or three-dimensional straight-through nanometer-sized pore passage, forming a nanostructured chiral molecule reactor, and displaying the high asymmetric inductivity. The value of the catalyst is higher than the homogeneous phase catalytic level, and the catalyst has the high reutilization property and important adaptation value. Further, the invention is easy to be commercially developed.

The invention provides an indoline compound with optical activity, namely R-5-(2-amidopropyl)-1-(3-(4-fluorine benzoyl oxygen group) propyl)-7-cyan indoline. The compound can be used as a key intermediate and used for preparing a chiral drug, namely, Silodosin. The invention also provides a preparation method of R-5-(2-amidopropyl)-1-(3-(4-fluorine benzoyl oxygen group) propyl)-7-cyan indoline, which is characterized by comprising the following steps: taking 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-nitrylpropyl)-7-cyan indoline as a raw material to obtain the 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-oxopropyl)-7-cyan indoline, carrying out asymmetric reaction on the 1-(3-(4-fluorine benzoyl oxygen group) propyl)-5-(2-oxopropyl)-7-cyan indoline and a cheap chiral auxiliary agent, namely alpha-phenylethylamine, wherein asymmetric inductivity is 6:1, and finally removing protective group.

The invention relates to an asymmetric hydrogenation method for ketone compounds, comprising the step of: under hydrogen atmosphere, in the presence of an in situ catalyst derived from a chiral ligand and a ruthenium salt, adding a ketone compound and a base into a second solvent to carry out an asymmetric hydrogenation for the ketone compound. The invention can obtain a conversion of 100% and a highest asymmetric inducement effect of 99.7% for the ketone compound. The invention has the advantages including simple procedure, high conversion and selectivity, good atom economy and good prospect of industrial application.