Nanometer structure cinchona alkaloid thiourea multi-phase bionic catalyst and preparation method thereof

Abstract

Provided is a nanostructured polyphase biomimetic catalyst of quinine and a process for preparing same, belonging to the catalytic field of preparing technology of biomimetic catalyst. The method for preparation of the novel catalyst is that mesoporous material with a nanometer-sized bore diameter is employed to be a vector, a functional group provided by the vector is employed to be a first platform and reacts with substance which has active primitives, and further a second reactive platform is provided and is assembled in situ inside a nanostructured space, thereby forming the objective catalyst. The catalyst has the characteristics that active components are assembled via high dispersion in a one-dimensional or three-dimensional straight-through nanometer-sized pore passage, forming a nanostructured chiral molecule reactor, and displaying the high asymmetric inductivity. The value of the catalyst is higher than the homogeneous phase catalytic level, and the catalyst has the high reutilization property and important adaptation value. Further, the invention is easy to be commercially developed.

Description

technical field [0001] The invention belongs to the biomimetic technology in the field of catalysis, and in particular provides a nanostructure cinchona-alkaline thiourea heterogeneous biomimetic catalyst and a preparation method thereof. Background technique [0002] Biomimetic technology is an intersecting, marginal and emerging discipline formed by researching the functional principles and mechanisms of various biological systems as biological models. In the field of catalysis, bionic technology is based on the fact that (1) the extraction and purification of biological enzymes is cumbersome and costly; (2) the application often requires the presence of cofactors of equal amounts of reactants to achieve catalytic activity; (3) it is extremely sensitive to the environment , easily deactivated and other inevitable limitations of a technology developed. At present, the biomimetic catalysts that have been studied more are mainly metal-organic complexes. Although this type of...

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Problems solved by technology

The catalyst exhibits high activity of promoting flowering and is widely used in Michael addition, Aldol condensation, Mannich reaction, α-amination, α-aminooxylation of aldehydes and ketones, Asymmetric conjugate addition, SN 2 Asymmetric reaction processes such as alkylation and [4+2]additon avoid the disadvantages of easy loss of active centers of metal-organic complex biomi

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