Dicyclopentadienyl iron pocket ligand possessing central chirality and planar chirality, synthesis method and uses

Abstract

The invention relates to a ferrocene ligand having central chirality and planar chirality, method for synthesizing and use thereof. The ligand has the central chirality of diamines, and is obtained through condensation of ferrocene phosphine aldehyde and chiral diamine, and further reduction, the ligand can be purified through recrystallization and column chromatography. The ligand can be used as catalyst in asymmetric alkylation reaction.

Description

technical field

[0001] The invention relates to a class of chiral ligands, synthesis methods and uses, that is, the synthesis and use of a ferrocene pocket ligand with central chirality and planar chirality. Background technique

[0002] Allyl substitution reaction is one of the more effective methods for constructing C-C bonds. Its asymmetric allylation of cyclic carbonyls and open-chain activated carbonyls yielded many good results. For the asymmetric allylation of simple carbonyls, however, not many good results have been achieved. No palladium-catalyzed asymmetric allylation of open-chain simple carbonyls has been reported. Pocket ligands have a good asymmetric induction effect in the asymmetric allylation reaction of simple carbonyl compounds. How to design and synthesize a new class of ligands with simple structure, easy synthesis and good catalytic activity is simple A hot direction in the study of asymmetric allylation of carbonyl compounds. Contents of the inve...

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