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A computer-implemented automated building design and modeling and construction project cost estimating and scheduling system (“DMES system”) is described. The DMES system provides a central source for all of the design and construction information for a construction project in a coordinated two-dimensional and three-dimensional spatial database that is freely accessible by all of the members of an interdisciplinary construction project team as a means to produce automatically coordinated design development and construction document information. The DMES system acquires and stores all of the appropriate design, engineering, and construction expertise and information available for any building type for use in automatically assembling and coordinating the design, cost-estimating, and scheduling for a construction project. In one embodiment, the DMES system consists of a plurality of objects, comprising elements and massing elements arranged in an assembly hierarchy. Each of the objects includes programming code that defines an interface and discrete internal functions that define its behavior. When instantiated in the database, the objects automatically create further instances of other objects in the hierarchy, which in turn do the same, thus assembling a complete building model automatically from the initial manually-placed instance. The building model enables automatic generation of drawings and cost and scheduling information. By running automatic iterations of the building model, multiple designs may be evaluated to determine the optimum design.

The invention concerns a superconducting high-field magnet system (1) for a high-resolution magnetic resonance spectrometer, comprising a magnet coil (4) which is superconductingly short-circuited during operation, and generates a homogeneous temporally stable magnetic field during operation that meets the requirements for taking a high-resolution magnetic resonance spectrum. The magnet coil (4) comprises an LTS partial coil (4b, 4c) and an HTS partial coil (4a, 4d). The LTS partial coil (4b, 4c) can be separately short-circuited in a pure LTS circuit (14b) via an LTS switch (15b), and the HTS partial coil (4a, 4d) can be separately short-circuited in a pure HTS circuit (14) via an HTS switch (15a) and both partial coils (4a, 4d; 4b, 4c) are connected via an LTS-HTS joint (20) and are charged by the same power supply.

A method and an assembly system for manufacturing an assembled camshaft having a metallic shaft and at least one shrunk-on cam, includes initially heating the at least one cam, threading the at least one cam onto the shaft in a predetermined position in the heated state, and subsequently shrinking the at least one cam onto the shaft due to a cooling down. The shaft is cooled down prior to thread-on of the cams so that the cams are shrunk onto the shaft due to a temperature equalization which includes heating of the shaft and cooling down of the cams. The assembly system includes multiple drums in which the shafts and the cams to be fitted are accommodated and cooled and / or heated. The shafts are cooled preferably with the aid of a cooling lance inserted into a hollow space of the shaft.

Disclosed herein are methods and devices for stimulating an immune response to a disease in a subject, which involves passing sub-microsecond long pulses of electric fields having an amplitude between 5 kV / cm and 68 kV / cm through an abnormal growth of a subject sufficient to suppress myeloid-derived suppressor cell (MDSC) or regulatory T cell (Treg) production, increase adenosine triphosphate (ATP) or high mobility group box 1 (HMGB1) production, or stimulate dendritic cell activation in the subject.

Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.

The invention relates to the production of light-amplifying optical material. Liquid reactant is atomized into droplets using a high velocity gas. The droplets are subsequently introduced into a flame. Reactants are oxidized in the flame and condensed by forming small particles. At least a fraction of said particles is collected and fused to form optical waveguide material, which is subsequently drawn to form an optical waveguide. According to the invention, the velocity of the atomizing gas stream is in the order of the velocity of sound. The high velocity enhances atomization and increases reaction rates in the flame. The residence times are reduced to such a degree that unwanted phase transformations in the produced particles are substantially minimized. Consequently, very homogeneous material is produced. Especially, in the production of erbium-doped silica, low percentage of clustered erbium ions is achieved.

A process for treating cellulosic fibres comprising pre-treating the fibres with an enzyme in a first enzymatic treatment followed by mechanical pre-treating the fibres in a first mechanical treatment and a second enzymatic treatment followed by a second mechanical treatment of the fibres to form micofibrillated cellulose. In this way it is possible to produce mircofibrillated cellulose (MFC) in an improved and energy efficient way.

A semiconductor element heat dissipating member is provided which has excellent heat dissipation characteristics and adhesion characteristics and enables production of a semiconductor device at a low cost. A semiconductor device using the same, and a method of producing the same are also provided. The semiconductor element heat dissipating member has a conductive substrate and an electrically insulating amorphous carbon film containing hydrogen, and the electrically insulating amorphous carbon film is formed at least on a region of the conductive substrate on which region a semiconductor element is to be mounted.

Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.

This invention discloses a method for reducing the intracellular lipid storage material of a cell, tissue, or organ for transplantation and features solutions, methods and kits that induce the metabolic elimination of lipid storage in a cell, tissue, or organ. In one exemplary approach, the process involves contacting a cell, tissue, or organ with a perfusate solution that include catabolic hormones and amino acids, at physiological conditions, to increase lipid export and lipid oxidation. If desired, the cell, tissue, or organ of the invention may also be heat shock preconditioned. The invention can be used to prepare, recondition, or store a cell, tissue, or organ for transplantation by increasing tolerance to ischemia-reperfusion and cold-preservation related injury.

A process for producing isolated and purified respiratory syncytial virus (RSV) fusion (F) and attachment (G) glycoproteins in eukaryotic cell cultures infected with RSV cold-passaged, temperature-sensitive mutant subgroup A2 strain cpts-248 / 404 results in at least a 5-fold increase in F and G protein yields when compared with the parent A2 strain. Immunogenic compositions comprising the F and / or G protein(s) produced by this process can be formulated for in vivo administration to a host to confer protection against disease caused by RSV.

The invention relates to isolated polynucleotides from Corynebacterium glutamicum which are useful in the regulation of gene expression. In particular, the invention relates to isolated polynucleotides comprising C.glutamicum promoters which may be used to regulate, i.e., either increase or decrease, gene expression. In certain embodiments, isolated promoter sequences of the present invention regulate gene expression through the use of exogenous or endogenous induction. The invention further provides recombinant vectors and recombinant cells comprising isolated polynucleotides of the present invention, preferably in operable association with heterologous genes. Also provided are methods of regulating bacterial gene expression comprising growth of a recombinant cell of the present invention. In particular, the present invention provides methods to regulate genes involved in amino acid production comprising growth of a recombinant cell of the present invention. In certain embodiments, the present invention provides methods of regulating gene expression in bacteria, particularly Corynebacterium species, especially of the genus Corynebacterium, comprising fermentation growth of a recombinant cell of the present invention, where metabolite concentrations, temperature, or oxygen levels are manipulated to regulate gene expression.

A method for weaving single-layered and / or multi-layered woven fabric, especially airbag fabric, includes interweaving warp threads delivered by at least two warp beams.

The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

The present invention relates to a production method of an optically active form of a compound represented by formula (II) wherein ring A is a benzene ring optionally having substituent(s); R1 is H, a hydrocarbon group optionally having substituent(s), an acyl group or an acyloxy group; R2, R3 and R4 are each H, an alkyl group optionally having substituent(s), an alkoxy group optionally having substituent(s) or an amino group optionally having substituent(s); X is N or CH; Y is N or CH; and * shows an asymmetric center, or a salt thereof, which includes reacting a compound represented by the formula (I) wherein each symbol is as defined above, or a salt thereof, with an excess amount of an oxidizing agent in the presence of a catalyst for asymmetric induction, and provides an efficient production method of an optically active sulfoxide derivative in high yield on an industrial large scale by a convenient method, while achieving an extremely high enantiomer excess.

To provide a spinous process spacer that can be stably inserted and fixed between split faces of a split spinous process in a gapless manner, without made-to-order production for each patient. There is provided a spinous process spacer (1) for insertion between split halves of a spinous process resulting from longitudinal splitting of the spinous process, wherein the spinous process spacer is formed in an approximately cylindrical shape and the opposite end faces (2, 3) thereof are constituted by planes which mutually form a fixed angle.

An improved structure for a sport board comprises: a first layer, which is a low density foam layer and has a first surface and a second surface; a second layer, which is a hardened layer, a first surface of the second layer being joined the second surface of the first layer; a third layer, which is a low density foam layer, a first surface of the third layer being joined a second surface of the second layer; and a cover layer, which is a waterproof layer, a first surface of the cover layer being completely joined the first surface of the first layer and a second surface of the third layer.

The invention provides a process for producing a single-crystal substrate with an off-angle, which comprises using, as a substrate, a material capable of epitaxial growth by a vapor-phase synthesis method, whose surface has an off-angle with respect to a crystal plane capable of epitaxial growth; implanting ions into the substrate having a surface with an off-angle to form a layer with a deteriorated crystal structure near the surface of the substrate; growing a crystal on the surface with an off-angle of the substrate by a vapor-phase synthesis method; and separating a grown crystal layer from the substrate. In accordance with the process of the invention, when producing off-substrates usable in vapor-phase synthesis of single crystals, the manufacturing costs can be reduced, and substrates with an identical off-angle can be produced easily and in large quantities.

To provide a process for producing a polyether, which comprises subjecting an alkylene oxide and the like to ring-opening addition polymerization to an initiator in the presence of a double metal cyanide complex catalyst (DMC catalyst), which can be carried out by use of a DMC catalyst at a low concentration, and accordingly the amount of the DMC catalyst remaining in a polyether to be obtained can be reduced.A process for producing a polyether, which comprises subjecting an alkylene oxide and an oxygen-containing heterocyclic compound other than an alkylene oxide, to ring-opening addition polymerization to an initiator having a hydroxy group in the presence of a DMC catalyst, wherein prior to the ring-opening addition polymerization, the DMC catalyst and the initiator are subjected to mixing treatment at a temperature of from 125° C. to 180° C. under an absolute pressure of at most 0.06 MPa for from 10 minutes to 24 hours.

The invention relates to a method for the production of an at least partially electrically conductive or semi-conductive element on a structure, wherein the element comprises one or more layers, the method comprising the steps of a) forming a formable element comprising one or more layers, wherein at least one layer comprises a network of high aspect ratio molecular structures (HARM-structures), wherein the HARM-structures are electrically conductive or semi-conductive, and b) arranging the formable element in a conformal manner onto a structure by pressing and / or vacuum sealing the formable element on a three-dimensional surface of the structure, for producing a conformal and at least partially electrically conductive or semi-conductive element comprising one or more layers, wherein at least one layer comprises a network of HARM-structures, on the three dimensional surface of the structure. Further, the invention relates to a conformal element and uses thereof.

An exterior rear view mirror, for a motor vehicle, with an exterior rear view mirror housing formed in at least two parts, which comprises an opening for a mirror glass, and houses at least one base bracket, on which the mirror glass is adjustably arranged. The exterior rear view mirror housing consists at least of a first housing part and a second housing part, which are connected to both each other as well as to the base bracket, in each case. Locking connections are provided at least between the first housing part and the second housing part, as well as between the housing parts and the base bracket, in each case.

The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and / or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.

A cis-TEVP fusion protein including a TEVP protease, a TEVP cleavage site and a target protein provide a platform for expression of the target protein. A trans-TEVP fusion protein including a TEVP cleavage site and a target protein, the amino-terminal portion of the target protein adjacent to the C-terminal portion of the TEVP cleavage site, the amino acidic residue in position P2 of the TEVP cleavage site being a Valine also produces the target protein by the same process. A cis-TEVP fusion protein system comprising the first fusion protein and a suitable host cell; a trans-TEVP fusion protein system comprising the second fusion protein and a suitable host cell; associated methods to produce target proteins, and kits of parts are also disclosed herein.

The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR activity, a method for designing the substance regulating EGFR activity, a method for designing an EGFR variant or an EGF variant, a method for producing an EGFR variant or an EGF variant and an EGF variant or an EGFR variant obtainable by such method, a method for designing an epitope using the structure coordinates of the EGF-EGFR complex, a method for producing an anti-EGFR antibody or an anti-EGF antibody and an antibody obtainable by such method, a polypeptide or a salt thereof comprising a region that forms an EGFR dimerization site, and the like.

The invention discloses a method for rapidly preparing a large tissue specimen slice. The method is simple, and the treatment process is rapid; furthermore, the method can meet the requirement of preparing the large tissue slice. The process comprises the following steps: (1) fixation: a specimen with the thickness smaller than 4mm is fixed by adopting 10 percent of formalin; (2) dehydration: gradient ethanol is selected for dehydration; (3) transparentization: chloroform or dimethyl benzene is adopted to perform transparentizing treatment; (4) wax impregnation; (5) embedment; (6) slicing; (7) coloration: the rapid preparation of the large tissue specimen slice is completed.

An exterior rear view mirror, for a motor vehicle, with an exterior rear view mirror housing formed in at least two parts, which comprises an opening for a mirror glass, and houses at least one base bracket, on which the mirror glass is adjustably arranged. The exterior rear view mirror housing consists at least of a first housing part and a second housing part, which are connected to both each other as well as to the base bracket, in each case. Locking connections are provided at least between the first housing part and the second housing part, as well as between the housing parts and the base bracket, in each case.