The application discloses STUB1 application of the
gene or the STUB1
protein coded by the
gene in the preparation of a
medicine for preventing or treating
obesity and related metabolic diseases STUB1 The application first proves that the
gene and the coded
protein are key target points for regulating fat
metabolism, and the bidirectional regulation value is determined: on one hand, inhibition of STUB1 can significantly up-regulate the CIDEC
protein level, promote normal fat storage of adipocytes, and improve
insulin resistance and non-
alcoholic fatty liver disease; on the other hand, activation of STUB1 can accelerate the degradation of CIDEC, inhibit
lipid storage, realize the effect of reducing fat, and provide a brand-new intervention target point and treatment idea for metabolic diseases such as
obesity, type 2 diabetes and
dyslipidemia.