Magnetic ferrite nanocrystal as well as preparation method and application thereof

A magnetic ferrite and nanocrystal technology, applied in the fields of magnetic objects, inductor/transformer/magnet manufacturing, magnetic materials, etc., can solve the problem of low biocompatibility, improve water solubility, high clinical translation significance, reduce effect of influence

Inactive Publication Date: 2021-10-26
徐州捷创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the preparation method of ferromagnetic nanomaterials usually adopts high-temperature pyrolysis method, but the nano-iron synthesized by this method is in the oil phase and has low biocompatibility.

Method used

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  • Magnetic ferrite nanocrystal as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] S1: Add 25ml of dibenzyl ether, 3ml of oleic acid and 1ml of oleylamine into a 50ml three-necked flask, continuously feed nitrogen to remove the oxygen in the system, add 2.2mmol of iron acetylacetonate and 0.8mmol of acetylacetonate respectively Manganese and 0.5mmol of zinc acetylacetonate are heated to 110°C by a program temperature control device, and the cap of the three-necked bottle is opened to remove water vapor in the solution, and then the cap is closed to make the acetylacetone complex, oleic acid and oleylamine completely React and maintain the temperature at 110°C for 1h;

[0035] S2: Next, continue to heat the S1 system to 220°C and maintain it for 2 hours, and observe that the solution changes from brownish red to bright black;

[0036] S3: Continue to raise the temperature of the S2 system to 300°C and maintain it for 1 hour;

[0037] S4: After the high-temperature reaction in step S3 is completed, remove the heat source at the bottom, transfer it to a...

Embodiment 2

[0043] Change the temperature in step S1 in Example 1 to 105°C, change the temperature in step S2 to 200°C, change the heating time to 2.5h, change the temperature in step S3 to 310°C, and change the heating time to 1.5h . Other conditions remain unchanged, the obtained Fe3O4@SM was scanned by electron microscope and found that the obtained Fe 3 o 4 @SM is uniform in size and approximately spherical in shape.

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Abstract

The invention belongs to the technical field of nano materials, and particularly relates to a magnetic ferrite nanocrystal, a preparation method and application thereof. The magnetic ferrite nanocrystal is obtained by the following steps: S1, adding ferric acetylacetonate, manganese acetylacetonate, zinc acetylacetonate, oleic acid and oleylamine into dibenzyl ether, and conducting reacting at 105-115 DEG C; S2, raising the temperature to 200-230 DEG C; S3, continuously raising the temperature to 290 to 310 DEG C; S4, conducting cooling, adding ethanol, and performing magnetic separation to obtain modified Fe3O4; S5, mixing the modified Fe3O4, chloroform and DSPE-PEG-COOH to obtain a mixed solution; S6, adding water into the mixed solution, and conducting heating at 50-70 DEG C to obtain Fe3O4-coated COOH; and S7, adding O-benzotriazole-N,N,N',N'-tetramethylurea hexafluorophosphate, N,N-diisopropylethylamine and streptavidin into the Fe3O4-coated COOH, and carrying out a reaction on the Fe3O4-coated COOH and the N,N-diisopropylethylamine and the streptavidin so as to obtain Fe3O4-coated SM.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a magnetic ferrite nanocrystal, a preparation method and an application thereof. Background technique [0002] Ferromagnetic nanomaterials have a wide range of applications in nuclear magnetic resonance imaging, targeted drug therapy, separation of biomolecules and cells, and clinical diagnosis. [0003] At present, the preparation method of ferromagnetic nanomaterials usually adopts high-temperature pyrolysis method, but the nano-iron synthesized by this method is in the oil phase and has low biocompatibility. Contents of the invention [0004] Aiming at the deficiencies in the prior art, the present invention aims to provide a kind of magnetic ferrite nanocrystal, select phospholipid encapsulation method to synthesize water-soluble Fe 3 o 4 , the method has good water solubility, uniform particle size distribution, and high biocompatibility. In the nucleic acid extrac...

Claims

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Application Information

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IPC IPC(8): C01G49/08H01F1/03H01F41/02
CPCC01G49/08H01F41/02H01F1/0315C01P2004/62C01P2006/42C01P2004/32
Inventor 史东生张俊谢俊薛明杰
Owner 徐州捷创生物科技有限公司
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