Application of butyric acid (butanoic acid) in preparing medicaments for treating anorectal diseases

A technology for anorectal diseases and butyric acid is applied in the application field of butyric acid (butyric acid) in the preparation of medicines for treating anorectal diseases, which can solve the problems of high recurrence rate and poor treatment effect, and achieves promoting intestinal peristalsis and restoring normal absorption and secretion. effect of function

Active Publication Date: 2008-10-29
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of drugs for the treatment of anorectal diseases such as hemorrhoids and anal fissure, but the treatment effect is generally poor, the recurrence rate after treatment is high, and it is difficult to cure, which brings physical and mental pain to patients.
However, so far, there has been no report on the application of butyric acid to treat hemorrhoids, anal fissures and other anorectal diseases, and this invention patent is hereby applied for

Method used

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Examples

Experimental program
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preparation Embodiment 1

[0021] Medicine preparation embodiment 1, sodium butyrate suppository preparation method

[0022] Take commercially available sodium butyrate 0.88% and mixed fatty acid glyceride 99.12% by weight percentage, so that the final suppository made contains sodium butyrate 80mmol / Kg.

[0023] Take sodium butyrate and pass it through a 100-mesh sieve before preparation, then heat the mixed fatty acid glycerides in a melting tank to 100°C to 105°C to melt, keep it warm for 30 minutes, stop heating until the temperature drops to 60°C, add sodium butyrate to dissolve, Stir well. Pour it into the plug mold, scrape off the excess material after cooling, and release it from the mold.

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Abstract

The invention discloses a new medicinal use of butyric acid, specifically relating to the application of the butyric acid in the preparation of drugs for curing anorectal disease. Anorectal disease comprises hemorrhoids and anal fissure. The butyric acid is produced to be the required dosage form by taking the butyric acid or butyrate as the main active ingredients, with preferred sodium butyrate as the main active ingredients. Other active ingredients can be added to improve the treatment effect.

Description

technical field [0001] The invention relates to a new pharmaceutical application of butyric acid (also known as butyric acid), in particular to the application of butyric acid or butyrate as a main pharmaceutical active ingredient in the preparation of medicines for treating anorectal diseases, which include hemorrhoids and anal fissures. Background technique [0002] Anorectal diseases can be suffered by both men and women, and both adults and infants can suffer from the disease. The national census data shows that the incidence of anorectal diseases in adults is about 60-75%. Although it is less life-threatening, those with severe illnesses often affect their normal work and life. Even those with mild illnesses still have to endure the pain of the disease from time to time. Among anorectal diseases, hemorrhoids and anal fissures are the most common. At present, there are many types of therapeutic drugs for anorectal diseases such as hemorrhoids and anal fissures, but the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K9/02A61K9/06A61K9/20A61K9/48A61K9/50A61P1/00
Inventor 崔云龙李洪福
Owner QINGDAO EASTSEA PHARMA
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