Chitosan gel and preparation method thereof

A chitosan gel and chitosan technology are applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of poor treatment effect, many side effects, pain, etc., to reduce scar formation, Inhibition of scar formation, good biocompatibility effect

Active Publication Date: 2014-09-10
DONGGUAN DAQING MEDICAL DEVICES CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hemorrhoids is a common disease located in the anus. It can occur at any age, but with age, the incidence rate gradually increases. It is known as "nine hemorrhoids in ten men" and "ten hemorrhoids in ten women". Hemorrhoids are usually incurable for a long time , bringing great inconvenience to normal life and work
[0003] The traditional treatment of hemorrhoids adopts injection therapy. The commonly used injections mainly include hardening atrophy agent and hemorrhoid necrosis shedding agent. The former is easy to relapse in the treatment of hemorrhoids, while the latter ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A kind of chitosan gel, this chitosan gel comprises the raw material of following percentage by weight:

[0077] Modified Chitosan 0.5%

[0078] Glycerin 0.5%

[0079] Alum 5%

[0080] Sodium Carboxymethyl Cellulose 0.2%

[0081] Carbomer 0.2%.

[0082] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 70%.

[0083] A kind of preparation method of chitosan gel, it comprises following preparation steps:

[0084] Step A, take each raw material by weight percentage, standby;

[0085] Step B, adding sodium carboxymethyl cellulose and carbomer to purified water respectively to make them fully swell to obtain sodium carboxymethyl cellulose swollen body and carbomer swollen body for later use;

[0086] Step C, dissolving modified chitosan, alum and menthol respectively, then mixing with glycerin, stirring evenly to obtain a mixed solution;

[0087] Step D, adding carboxymethylcellulose sodium swelling body and carbomer swelling body to th...

Embodiment 2

[0089] A kind of chitosan gel, this chitosan gel comprises the raw material of following percentage by weight:

[0090] Modified Chitosan 2.5%

[0091] Glycerin 10%

[0092] Alum 3%

[0093] Menthol 0.09%

[0094] Sodium Carboxymethyl Cellulose 2%

[0095] Carbomer 0.5%.

[0096] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 95%.

[0097] Chitosan gel also comprises the plant extract that weight percent is 1%, and described plant extract comprises the raw material of following weight portion:

[0098] Treats 30 servings

[0099] Cimicifuga 20 parts

[0100] Gacia 10 parts

[0101] 10 parts white fresh skin

[0102] 20 fig leaves

[0103] Radix Paeoniae Rubra 10 parts,

[0104] Add purified water to the above-mentioned raw materials for refining, filter the filtrate, concentrate and dry to obtain the plant extract.

[0105] A kind of preparation method of chitosan gel, it comprises following preparation steps:

[0106] Step A, ta...

Embodiment 3

[0111] A kind of chitosan gel, this chitosan gel comprises the raw material of following percentage by weight:

[0112] Modified Chitosan 1.5%

[0113] Glycerin 12%

[0114] Alum 4%

[0115] Sodium Carboxymethyl Cellulose 2%

[0116] Carbomer 0.7%.

[0117] The modified chitosan is carboxymethyl chitosan with a carboxylation degree of 80%.

[0118] Chitosan gel also comprises the plant extract that weight percentage is 4%, and described plant extract comprises the raw material of following weight portion:

[0119] Treats 50 parts

[0120] Cimicifuga 30 parts

[0121] Gacia 20 parts

[0122] 20 servings of white fresh skin

[0123] 30 fig leaves

[0124] Radix Paeoniae Rubra 15 parts,

[0125] Add purified water to the above-mentioned raw materials for refining, filter the filtrate, concentrate and dry to obtain the plant extract.

[0126] A kind of preparation method of chitosan gel, it comprises following preparation steps:

[0127] Step A, take each raw material ...

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PUM

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Abstract

The invention relates to the technical field of biogel, specifically to chitosan gel and a preparation method thereof. The gel comprises the following raw materials by weight: 0.5 to 4.5% of modified chitosan, 0.5 to 15% of glycerin, 0.5 to 5% of alum, 0.01 to 0.13% of menthol, 0.2 to 5% of carboxymethylcellulose sodium and 0.2 to 1% of carbomer. The gel is a drug delivery system with a controlled-release function, can improve availability of effective substances, can be tightly applied on an uneven wound without adhesion, avoids secondary harm, has good biocompatibility and strong antibiosis and antiphlogosis effects, incurs no local irritation and no adverse reaction, is capable of rapidly promoting wound healing and effectively treating hemorrhoids, enables hemorrhoids not to recur and is applicable to improvement of symptoms like hemorrhoidal bleeding, hyperemia and oedema of the mucous membranes of hemorrhoids, bearing-down swelling of the anus, constipation, prolapsus of hemorrhoid nuclear and the like caused by internal hemorrhoids, external piles and mixed hemorrhoids and control, nursing and the like after anal fissure and anorectal operations.

Description

technical field [0001] The invention relates to the technical field of biogel, in particular to a chitosan gel and a preparation method thereof. Background technique [0002] Hemorrhoids is a common disease located in the anus. It can occur at any age, but with age, the incidence rate gradually increases. It is known as "nine hemorrhoids in ten men" and "ten hemorrhoids in ten women". Hemorrhoids are usually incurable for a long time , Bring great inconvenience to normal life and work. [0003] The traditional treatment of hemorrhoids adopts injection therapy. The commonly used injections mainly include hardening atrophy agent and hemorrhoid necrosis shedding agent. The former is easy to relapse in the treatment of hemorrhoids, while the latter has more side effects. It is painful and does not require hospitalization, but it can only be applied to smaller hemorrhoids, and cannot treat fourth-degree hemorrhoids; surgical resection of hemorrhoids, although the treatment is co...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/06A61P9/14A61K31/722A61K31/045A61K33/06
Inventor 梁奕福
Owner DONGGUAN DAQING MEDICAL DEVICES CO LTD
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