87results about How to "Fast pain relief" patented technology

A method of treating a subject having a musculoskeletal disorder includes administering to a subject's articular site in need thereof an effective amount of a hyaluronic acid (HA) composition. In one embodiment, the HA composition includes an HA derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or 0-acyl isourea, or both N-acylurea and 0-acyl isourea. In another embodiment, the HA composition includes a crosslinked HA gel that is prepared by reacting an uncrosslinked HA with a biscarbodiimide in the presence of pH buffer in a range of between about 4 and about 8. The composite can optionally include at least one second bioactive agent other than the HA derivative, such as a steroid.

A pharmaceutical formulation for delayed release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt. % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.5 hours; 5 to 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 1 hour; 10 to 75% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 2 hours; 15 to 82% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 3 hours; 30 to 97% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 6 hours; more than 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 12 hours; more than 70% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 18 hours, and more than 80% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 24 hours.

A pharmaceutical dosage form comprising celecoxib and a pharmaceutically acceptable carrier, the dosage form when initially administered to at least 12 human patients in the fasted state in a crossover study providing: (a) a mean blood plasma concentration of celecoxib within 0.5 hour after administration (C_0.5) of at least about 0.9 ng/ml per mg of celecoxib dosed; (b) a mean blood plasma concentration of celecoxib 12 hours after administration (Ci2) of at least about 0.6 ng/ml per mg of celecoxib dosed; (c) a mean area under the blood plasma concentration versus time curve for the 12 hour period following administration (AUC₁₂) of at least 19 ng-hr/mL per mg of celecoxib dosed; and (d) a mean maximum blood plasma concentration (C_max) of celecoxib of less than about 4.9 ng/ml per mg of celecoxib dosed.

The utility model discloses an adhesive plaster for skin and a use method. The adhesive plaster comprises a fabric layer, a plaster layer and a protecting layer that are sequentially superposed and arranged, wherein the fabric layer elastically stretches along length stretching direction and is not elastic in width direction; the plaster is evenly distributed on the inside surface of the fabric layer, and the plaster takes the shape of continuous strap and is arranged at intervals along width direction; and the protecting layer is release paper or release film. In virtue of the sticky elastic property of the plaster layer and the mechanical direction of the fabric layer and in combination with the principles of kinesiology and biomechanics to influence the trend of skin and increase the gap between skin and muscle, the adhesive plaster further promotes the lymph and blood circulation, removes a number of fatigue metabolic substances in vivo, pain products, metabolic substances remaining after inflammatory reaction, small inner haemorrhage and the like, and achieves the purposes of relieving pain, slowing down inflammation, speeding up recovery and avoiding harm. The treatment process is suitable for all parts on the body surface, and widely applicable to various groups of people.

The present invention relates to a process for the preparation of solubilized ibuprofen, preferably in granular form, comprising the steps of: providing a mixture comprising solid ibuprofen and a first base, said first A base is selected from sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate and third generation sodium and potassium phosphates and mixtures thereof, and ibuprofen and the first base are mixed in a substantially dry state response. The granules and pharmaceutical compositions obtained and the dosage forms prepared therefrom are distinguished by their high solubility and fast disintegration and dissolution in aqueous media, good flowability and compressibility, fast onset of analgesic action.

A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-forming, hydrophilic or hydrophobic polymer and having the following in vitro dissolution rate relative to 100 wt. % of the 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol contained in the formulation: 3-35 wt. % released after 0.5 hour, 5-50 wt. % released after 1 hour, 10-75 wt. % released after 2 hours, 15-82 wt. % released after 3 hours, 30-97 wt. % released after 6 hours, more than 50 wt. % released after 12 hours, more than 70 wt. % released after 18 hours, and more than 80 wt. % released after 24 hours.

The invention provides external-use ointment for treating empyrosis and a preparation method thereof. The external-use ointment is empyrosis humectation ointment prepared from Chinese medicaments and Western medicaments through processing, and comprises the following components in part by weight: 10 to 30 parts of Chinese angelica, 10 to 25 parts of golden thread, 10 to 25 parts of amur corktree bark, 10 to 25 parts of baical skullcap root, 10 to 20 parts of prepared frankincense, 20 to 25 parts of prepared myrrh, 1 to 3 parts of musk, 10 to 20 parts of borneol, 150 to 270 parts of silver sulfadiazine powder, 500 to 1,000 parts of Vaseline and 40 to 80 parts of bees wax. The ointment adopts the Chinese angelica, the frankincense and the myrrh which have the effects of activating blood circulation, relieving pain and promoting tissue regeneration; the golden thread, the amur corktree bark and the baical skullcap root have the effects of clearing away heat and toxic materials and eliminating dampness; the borneol has bitter and cold properties, can clear away heat to be cool when in external use, and has the lasting effect of constringency, tissue regeneration and odynolysis when being compatible with the musk; and the silver sulfadiazine powder has the effects of sterilization and antiphlogosis. The whole medicament has the effects of promoting blood circulation by removing blood stasis, diminishing inflammation and relieving pain, changing rot and promoting tissue, inhibiting exudation and promoting wound healing, and has low incidence rate of scar.

A Chinese medicine in the form of ointment of spray for treating burn, scald and sore is prepared from 9 Chinese-medicinal materials including gypsum, calamine, cuttlefish bone, pearl, etc through respectively calcining and parching, pulverizing, proportional mixing, adding vaseline, and stirring. Its advantage is high curative effect.

Liquid formulations of celecoxib have been found to provide faster pain relief than conventional solid formulations of celecoxib. The present invention provides combinations of excipients in which celecoxib is highly soluble for formulation as pharmaceutical compositions.

The invention relates to traditional Chinese medicine for eliminating pain and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for eliminating pain is prepared from such raw materials as musk, safflower carthamus, panax notoginseng, dragon's blood, incised notopterygium, ligusticum wallichii, asarum sieboldii, peach kernel, radix angelicae, cassia twig and the like by independently soaking, steaming, fermenting and distilling in groups and mixing. The traditional Chinese medicine disclosed by the invention has beneficial effects that the traditional Chinese medicine for eliminating pain is prepared from natural Chinese herbal medicines through a fermentation process; the traditional Chinese medicine, which can be smeared on or sprayed to an affected part, can rapidly permeate skin so as to accelerate tissue repair, relieve capillary dilation, cell edema, soft tissue injury, local inflammation and like problems, to effectively improve local edema, pain or dermal inflammation, provide nutrition to tissue cell regeneration or soft tissue recovery, offer effective help to bone joint lubrication and cell reconstruction, significantly shorten recovery time in patients with bone and joint diseases and relieve the feeling of pain.

A portable, flexible, versatile athletic massage device with improved adjustable therapeutic massage is described. It is comprised of one or more vibrating units embedded in a pliant wrap-around material. The wrap may be optionally pneumatically inflated, deflated, heated, cooled to adjust comfort level and snugness of the device. The vibrating head(s) provide pulsating massage that is manually or programmatically adjustable. The wrap may additionally contain one or many electro-stimulation devices/electrodes for providing localized muscle stimulation. These device is controlled using electronic controller(s) powered by electrical, battery or known power sources. The controller is operated manually or through preset programs, remote controls and/or through voice control. The wrap provides comfortable intimate contact with the body facilitating better relief of the injury/pain. Individual customization of massage of the target area is possible through user variable power supply and user variable placement of vibrating heads and electro-stimulators in the wrap.

The invention relates to the field of drugs, in particular to an external-use drug for treating pain in waist and lower extremities, a process and application. The external-use drug is prepared from radix clematidis, rhizoma et radix notopterygii, radix angelicae pubescentis, rhizoma curcumae, radix notoginseng, radix aconiti, radix aconiti kusnezoffii, black pepper, radix angelicae dahuricae, herb of tuberculate speranskia, frankincense, myrrh, unprocessed rhizoma pinelliae, unprocessed arisaema cum bile, herbal asari, rhizoma drynariae, radix dipsaci, semen strychni, sophorra flavescens, cortex dictamni and fructus kochiae. The external-use drug can efficiently and rapidly treat cervical spondylosis, protrusion of lumbar intervertebral disc, lumbar muscle degeneration, chronic injury diseases and multiple kinds of internal and external rheumatic arthritis, and is wide in disease adaptation range.

A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.

The invention discloses a Chinese medicinal soft capsule for treating gastral cavity pain and a preparation method thereof. The soft capsule is prepared from 75 to 95 weight percent of litsea lancilimba, 5 to 25 weight percent of blumea camphor and appropriate amount of auxiliary materials. The Chinese medicinal soft capsule has the effects of promoting qi circulation and relieving pain, and is mainly used for treating symptoms such as gastral cavity pain, acid regurgitation during belching, tumescence, stethalgia, chest distress, short breath, palpitation and the like which are caused by qi stagnancy and blood stasis. The original stomach analgesic capsules are changed into the soft capsule preparations; and the Chinese medicinal soft capsule has improved stability and curative effect, accurate contents of the medicaments, beautiful appearance, high purity, little administration dosage, high bioavailability, stable quality, good curative effect and good safety.

The invention relates to an external traditional Chinese medicinal healthcare preparation with effects of beautifying features, relieving pain and relieving itching and a preparation method thereof. The effective ingredient of the traditional Chinese medicinal preparation is prepared from the following raw materials in parts by weight: 5-10 parts of pseudo-ginseng, 10-20 parts of costus roots, 10-20 parts of sappanwood, 10-20 parts of radix angelicae lateralis preparata, 10-20 parts of myrrh, 10-20 parts of coptis chinensis, 10-20 parts of cortex phellodendri, 10-20 parts of flos carthami, 20-30 parts of pittosporum roots, 20-30 parts of rheum officinale, 20-30 parts of mint, 5-10 parts of borneol, 10-20 parts of lithospermum purpurocaeruleum, 20-30 parts of salviae miltiorrhizae, 10-20 parts of philippine flemingia roots, 8-12 parts of rhizoma corydalis, 10-20 parts of menthol, 20-30 parts of shinyleaf pricklyash roots and 10-20 parts of honeysuckles. The external traditional Chinese medicinal healthcare preparation can play a role in quickly beautifying the features when externally used, has the effects of relieving pain and relieving itching vigorously, and has an obvious curative effect of quickly relieving pain on trauma symptoms of a traumatic injury, a knife wound, a burn and a scald.

The invention relates to a preparation method of a fast analgesic paste for treating gout and a formula of the fast analgesic paste and belongs to the preparation scope of external use medicines. The preparation method comprises the following steps: regularly soaking 30-50 cloth towels of which the areas are (1-5 cm)*(2-10 cm) respectively in ethanol soaking liquid prepared by 18 Chinese herbal medicines, i.e. 100g of lycopodium clavatum, 100g of phryma leptostachya, 50g of cinnamomum wilsonii, 60g of notopterygium root, 60g of radix angelicae pubescentis, 60g of angelica, 60g of prepared radix aconite, 60g of prepared kusnezoff monkshood root, 50g of asarum, 50g of polygonum cuspidatum, 60g of rhizoma smilacis glabrae, 120g of edible tulip, 60g of fevervine, 60g of salvia miltiorrhiza, 40g of climbing fern spore, 50g of fructus kochiae, 60g of borneol and 30g of liquorice and ethanol and is packed and sealed for standby. When the gout is acutely attacked, 1-2 pastes in the soaking liquid are clamped by forceps according to the area of a painful part and are externally applied to a pain position to quickly cool, disperse swelling, diminish inflammation and relieve pain.

The invention relates to a transdermal patch (or poultice) with functions of expelling wind and removing dampness and reducing swelling and easing pain and a preparation method thereof; the transdermal patch is composed of a backlining layer, a medicine storage layer and an anti-sticking layer; the medicine storage layer comprises the following ingredients: 20-30 percent of framework material, 22-32 percent of tackifier, 25-35 percent of stuffing bulking agent, 6-13 percent of lubricating agent, and 6-13 percent of medicine, the medicine mainly comprises more than 30 kinds of extract prepared by traditional Chinese medicines, such as suberect spatholobus stem, spathodea campanulata, schefflerakwangsiensis, climbing entada, Ilex godajam dry skin, fissistigma polyanthum and the like, the medicines are pasted to obtain tongzhongling transdermal patch the according to the process steps and the mixing proportion; as no solvent is used in the production, the production cost is reduced by 1/3, the pesticide effect is improved, the drug administration times are reduced, the usage is convenient, cutaneous anaphylaxis is reduced, and the compliance of patients is improved; the tongzhongling transdermal patch has the effect of expelling wind and removing dampness and reducing swelling and easing pain and is clinically used for rheumatoid arthritis and traumatic injury.

The present invention discloses Chinese medicine for curing traumatic injury and its preparation process. Its composition includes: notoginseng: ligusticum: dahurian angelica root: Chinese angelica root: wingless cockroach; carthamus flower: corydalis tuber=26-34:4-10:4-10:4-10:4-10:4-10:5:11. Its effective rate can be up to 100%.

The invention relates to a traditional Chinese medicine raw powder application patch for cancer pain and a preparation method thereof, wherein the traditional Chinese medicine raw powder application patch is used for various cancer pain symptoms. The traditional Chinese medicine raw powder application patch for cancer pain adopts 10-15 parts of hedyotis diffusa, 10-15 parts of herba portulacae, 10-12 parts of herba scutellariae barbatae, 10-12 parts of rhizoma sparganii, and 10-12 parts of curcuma zedoary. The traditional Chinese medicines are subjected to raw material quality testing firstly,crushed to 40 mesh at low temperature, then mixed evenly and loaded into aseptic non-woven bags. The invention relates to the novel preparation process of the traditional Chinese medicine raw powderapplication patch; the preparation process has the advantages of no boiling, energy saving and no pollution, and gives full play to the functions of traditional Chinese medicine raw powder, such as functions of clearing away heat and toxic materials, eliminating wind evil and damp evil, dampness and evil, eliminating swelling and diminishing inflammation, greatly reduces the production cost in theproduction process, and has good economic and social benefits.