Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof

A technology for wound healing and anorectal surgery, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc. It can solve the problems affecting the quality of life of patients and the time to return to work, affecting the healing of anorectal wounds, and the easy occurrence of anus in patients. Pain and other problems, to reduce capillary permeability, reduce local congestion or edema, and promote ulcer healing

Inactive Publication Date: 2014-04-16
武汉市第八医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its treatment method is mainly based on surgery, but because postoperative patients are prone to anal pain, bleeding, edema, swelling and other reactions and complications, which affect the healing of postoperative wounds of anorectal diseases and bring great pain to patients physically and mentally. Directly affect the quality of life of patients after surgery and the time to return to work

Method used

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  • Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof
  • Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof
  • Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A traditional Chinese medicine for wound healing after anorectal surgery, made of the following raw materials:

[0020] Nepeta 150g, Rhubarb 30g, Phellodendron 100g, Dandelion 75g, Sophora flavescens 100g, Fangfeng 50g, Burnet 100g, Mint 100g, Digupi 75g, Artemisia argyi 100g, Xuanming powder 150g, Speranthum 75g, Sophora japonica 75g, Forsythia 100g, salt 150g.

[0021] The preparation method is as follows: take Phellodendron cork, Dandelion, Sophora flavescens, Fangfeng, Burnet, Digubark, Speranthum, and Forsythia, add 6 times the water according to the weight, soak in cold for 40 minutes, heat and decoct for 40 minutes, and then add Nepeta chinensis . Add Xuanming powder and salt and concentrate to 2100ml.

[0022] Quality inspection results: the content of matrine is 1.3μg / ml.

Embodiment 2

[0024] A traditional Chinese medicine for wound healing after anorectal surgery, made of the following raw materials:

[0025] Nepeta 150g, Rhubarb 30g, Phellodendron 100g, Dandelion 75g, Sophora flavescens 100g, Fangfeng 50g, Burnet 100g, Mint 100g, Digupi 75g, Artemisia argyi 100g, Xuanming powder 150g, Speranthum 75g, Sophora japonica 75g, Forsythia 100g, salt 150g.

[0026] The preparation method is: take Phellodendron, Dandelion, Sophora flavescens, Fangfeng, Burnet, Digubark, Speranthum, Forsythia, Nepeta, Rhubarb, Mint, Artemisia argyi, Sophora japonica, add 40% ethanol, soak for 3 hours first, Then seep at a speed of 6ml / min for 12 hours, collect the seepage and add Xuanming powder and salt, recover ethanol and concentrate to 2100ml.

[0027] Quality inspection results: the content of matrine is 1.7μg / ml.

Embodiment 3

[0028] Embodiment 3 pharmacodynamics test

[0029] 1. Materials

[0030] 1.1 Drug Examples 1 and 2, concentrated to 1.2 g of medicinal materials per ml); Dragon Ball Ointment, provided by Wuhan Mayinglong Pharmaceutical Co., Ltd.

[0031] 1.2 Animal SD rats, weighing 250±20g, half male and half male, provided by Hubei Provincial Center for Disease Control and Prevention.

[0032] 1.3 Strain Staphylococcus aureus bacteria liquid, containing 300 million bacteria per ml, provided by the Microbiology Laboratory of Hubei University of Traditional Chinese Medicine.

[0033] 2. Method

[0034] 2.1 Effect on skin ecchymosis of guinea pigs

[0035] Depilate the back of the guinea pig, then pinch the skin with pliers, and apply force gradually to the degree of causing subcutaneous bleeding in the guinea pig. After 1 hour, ecchymosis appears, measure the area of ​​ecchymosis, and then apply the drug to the ecchymosis, twice a day, continuously Observe for a week, measure the diameter...

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Abstract

The invention discloses a traditional Chinese medicine used for anorectal surgery wound healing and a preparation method thereof. The medicine is made from fourteen traditional Chinese medicinal materials such as herba schizonepetae, rheum officinale, cortex phellodendri, dandelion, radix sophorae flavescentis, Chinese parsnip roots, garden burnet, mint, cortex lycii radicis, mugwort leaves, compound of glauber-salt and liquorice, garden balsam stems, flos sophorae and fructus forsythia, and edible salt. The invention further discloses a preparation method of the medicine. According to the invention, the method of hip bath is adopted, so that the liquid medicine can directly act on the wound surface. Results of clinical researches show that the medicine has efficacy of clearing away heat and toxic materials, removing rots, eliminating pus, promoting blood circulation to remove blood stasis and generating tissue and healing wound and the medicine is applicable to anorectal diseases such as downward flow of damp-heat hemorrhoids, anal fissure, anal fistula, anal carbuncle, perianal abscess and the like. The curative effect is superior to that of metronidazole in a control group.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for wound healing after anorectal surgery, and also relates to a preparation method of the traditional Chinese medicine. Background technique [0002] Anorectal disease refers to a series of diseases related to the anus and rectum, common ones include hemorrhoids, anal fissure, anal cryptitis, anal carbuncle (abscess around the anorectum), anal leak (anal fistula), prolapse of the anus (anorectal prolapse) , polyp hemorrhoids (rectal polyps) and clavicle hemorrhoids (anal canal cancer) etc., are common clinical diseases and frequently-occurring diseases. Its treatment method is mainly based on surgery, but because postoperative patients are prone to anal pain, bleeding, edema, swelling and other reactions and complications, which affect the healing of postoperative wounds of anorectal diseases and bring great pain to patients physically and mentally...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P17/02A61P9/14A61K33/04A61K33/14
Inventor 俞立民唐迎春刘红英高琼邱俊刘国保何佳
Owner 武汉市第八医院
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