28 results about "Arterial aneurysm" patented technology

Provided is a method for determining a plane in three-dimensional shape to obtain precise size information of an aneurysm. The method includes generating an aneurysm region including: generating a vessel mesh; obtaining at least one input point; generating a separating plane based on the at least one input point; and generating the aneurysm region based on the separating plane.

Provided is a method for generating an aneurysm region performed by an electronic device including: obtaining, by at least one processor, input images; generating, by the at least one processor, a vessel mesh based on the input images; determining, by the at least one processor, an adhered vessel from the vessel mesh; and separating, by the at least one processor, the adhered vessel based on user input.

The vascular prosthesis includes a luminal graft component that defines at least one fenestration and a crimped adapter at the at least one fenestration. The crimped adapter includes a perimeter and an opening with a diameter smaller than the diameter of the fenestration, and includes a crimped portion of generally concentric folds about the opening. The opening can move relative to the perimeter region of the crimped adapter to accommodate positioning of a branch prosthesis extending through the crimped adaptor. The vascular prosthesis is implanted in a patient to thereby treat, for example, an arterial aneurysm that spans a region of an artery that includes at least one arterial branch.

A stent graft for treating an arterial aneurysm includes loops fixed to struts of stents, wherein the struts define distal and proximal apices. The ends of a ligature can be linked by a wire in a stent graft delivery system that threads anchor loops longitudinally spanning ends of the ligature to maintain the stent in a radially constricted position during delivery to the aneurysm. A delivery system and method for implanting a stent graft prosthesis includes and employs a torque component at a distal end of the stent graft prosthesis, whereby following advancement of the stent graft to a surgical site in a constrained or partially constrained configuration, torque is applied to the torque component to rotationally align the stent graft about a longitudinal axis of the stent graft, followed by deployment of the stent graft in correct rotational alignment. A delivery system and method of its use includes an apex capture assembly, a leg clasp, and a leg stop for capturing a stent graft during orientation and stabilization at an implantation site of a surgical site.

The present invention provides a method and system for determining the aneurysm surgical process suitable for medical care. The method includes: creating a three-dimensional model of cerebral blood vessels corresponding to brain vascular tissue, and performing model recognition to determine each aneurysm tissue located therein; determining the side vascular tissue that is connected to each aneurysm tissue, and determining the thickness attribute and length attribute of the side vascular tissue; determining the clamping specification of the corresponding virtual clamping structure based on the thickness attribute, and determining the initial clamping position corresponding to the virtual clamping structure based on the length attribute; generating a virtual clamping structure corresponding to the clamping specification, and clamping the virtual clamping structure to the side vascular tissue based on the initial clamping position; judging whether the virtual clamping structure has an interference relationship with other entity parts other than the side vascular tissue, and adjusting the virtual clamping structure based on the initial clamping position if there is an interference relationship. The present invention at least improves the efficiency of medical diagnosis assistance.

The invention belongs to the field of biomedicine, and provides application of bile acid and derivatives thereof in prevention or treatment of intracranial aneurysm. The invention particularly relates to application of ursodesoxycholic acid and bile acid combined with ursodesoxycholic acid in preparation of drugs for preventing or treating intracranial aneurysm. According to the method, metabonomics analysis is carried out on a human blood sample, and the early warning effect of ursodesoxycholic acid and bile acid combined with ursodesoxycholic acid on intracranial aneurysm rupture is found; the verification of the influence effect of ursodesoxycholic acid and bile acid combined with ursodesoxycholic acid on the rupture probability of intracranial aneurysm in a mouse intracranial aneurysm model proves that the substance has a protective effect on intracranial aneurysm, namely the risk of intracranial aneurysm rupture is reduced; and an experimental basis is provided for the drug treatment of intracranial aneurysm and the reduction of clinical rupture risk.

The present disclosure relates to a method and system for acquiring and analyzing physiological signals of a subject to detect the risk or occurrence of stroke or cerebral infarction. A wearable wireless device may be used with one or more electrode clusters to record physiological signals during a sleep-wake cycle. The physiological signal may be utilized to perform sleep and wakefulness analysis. In some examples, physiological signals corresponding to each hemisphere of the brain may be compared, e.g., using coherence, to quantify asymmetry across the hemispheres and identify possible stroke, asymptomatic cerebral infarction (SBI), or aneurysm. Biomarkers may be extracted based on sleep and wakefulness analysis as well as coherence. Biomarkers may include an indication of obstructive sleep apnea or apnea risk, a reduction in slow wave sleep duration, or the presence of SBI or aneurysm. A stroke risk score may be generated from the biomarkers using a predictive model for the early detection of individuals that are potentially at risk of stroke.

The present application relates to a semi-automatic measurement method for morphological parameters of intracranial aneurysms, including: A1, based on a first mask combination of a single aneurysm, obtaining a first aneurysm diameter plane and a first blood flow direction vector; A2, based on the first aneurysm diameter plane, the first blood flow direction vector and the aneurysm mask in the first mask combination, according to the calculation rules of each parameter value in the parameter information, obtaining the parameter information of the aneurysm; A3, based on the predefined aneurysm circumscribed rectangular frame condition, according to the first aneurysm diameter plane, the first blood flow direction vector and the aneurysm mask in the first mask combination, obtaining the aneurysm circumscribed rectangular frame; A4, based on the first mask combination, the aneurysm circumscribed rectangular frame and the aneurysm parameter information, outputting a visualization result for doctors to view. The present method assists the segmentation of aneurysms and tumor-bearing vessels by manually adjusting tools, thereby ensuring the accuracy of parameter calculation.

The disclosure discloses a method for tracking a blood vessel center line and related products, which comprises: taking a starting point of a blood vessel contained in target angiography data as a center point, and intercepting an image block of a preset size; inputting the image block into a trained blood vessel center line tracking model for center line tracking to output a next center point of the center point; taking the next center point as a new center point, intercepting a new image block of a preset size; based on the new image block, proceeding to input the image block into the trained blood vessel center line tracking model for center line tracking to output a next center point of the center point, and continuing to execute until no new center point is output; and determining a center line of the blood vessel based on all the center points. By using the scheme of the disclosure, the influence of a large aneurysm on blood vessel center line extraction can be avoided, and the accuracy of blood vessel center line tracking is improved.

The invention provides an aneurysm identification method and device and a storage medium. The method comprises the following steps: acquiring a three-dimensional ultrasonic image for identification, and determining an aneurysm tissue in the three-dimensional ultrasonic image; performing morphological evaluation on the aneurysm tissue, and in response to an evaluation result meeting a preset tissue processing condition, constructing a processing demonstration model corresponding to the aneurysm tissue; acquiring a blood flow direction path of blood tissue in the artery of the patient in the aneurysm tissue, and determining each impact point location of the blood tissue for blood impact in the aneurysm tissue based on the blood flow direction path; determining risk assessment values based on a preset risk assessment strategy, determining the impact point location with the lowest risk assessment value as a coil starting point location, and determining the impact point location with the highest risk assessment value as a coil termination point location; and carrying out coil filling demonstration in the tissue demonstration model based on the coil starting point location and the coil ending point location. The medical auxiliary efficiency is at least improved.

This invention provides an auxiliary stent for intracranial aneurysm embolization, belonging to the field of medical device technology. The stent includes a stent body, which extends axially and includes a first anchoring section, a support section, a second anchoring section, and a third anchoring section integrally arranged sequentially. The first anchoring section has a semi-open loop structure and forms a funnel-shaped structure. The support section has a closed loop structure and is positioned at least directly opposite the neck of the aneurysm to provide the main radial support force to resist the outward pressure of the spring coil. The second anchoring section has a semi-open loop structure and a funnel-shaped structure. The third anchoring section has an open loop structure and forms a continuous funnel-shaped structure with the second anchoring section. Through its segmented structural design, this invention significantly improves the apposition and positional stability within the blood vessel, thereby effectively reducing the risk of complications related to stent displacement and poor apposition.

The present application relates to a method, computer device, readable storage medium and program product for obtaining the segmented position of an intracranial aneurysm in a blood vessel, comprising: obtaining the three-dimensional position coordinates of the aneurysm; obtaining a segmented intracranial arterial tree; combining the three-dimensional position coordinates of the aneurysm and the segmented intracranial arterial tree to obtain a three-dimensional intracranial vascular model including the intracranial arterial tree and aneurysm position information; establishing a standard intracranial vascular model and performing segmented annotation; spatially registering the three-dimensional intracranial vascular model with the standard intracranial vascular model to obtain a registered three-dimensional intracranial vascular model; on the registered three-dimensional intracranial vascular model, selecting pixel points on the aneurysm whose distance from the intracranial arterial tree is within a preset threshold range, obtaining mapping points corresponding to the pixel points on the standard intracranial vascular model, and obtaining the segmented position of the aneurysm on the intracranial arterial tree based on the positions of the mapping points.

Systems and a support structure for treating an aneurysm are provided. A system includes a stabilizing structure that is configured to surround a lumen structure that facilitates blood flow through the aneurysm where the support structure includes one or more elements that are configured to expand to fill a space in an aneurysmal sac.

The application relates to an intracranial aneurysm microfluidic blood vessel chip, system, preparation method and application, and belongs to the medical technical field.The intracranial aneurysm microfluidic blood vessel chip comprises a Y-shaped microfluidic channel, a negative pressure suction cavity and an elastic film, the negative pressure suction cavity is used for being connected with a negative pressure suction device to vacuumize the negative pressure suction cavity, the Y-shaped microfluidic channel meets at a crossing, the crossing is provided with an opening, the elastic film is arranged at the opening and separates the negative pressure suction cavity from the Y-shaped microfluidic channel, the elastic film is a treated polyisoprene film, and the treatment comprises plasma treatment; when the negative pressure suction cavity generates negative pressure, the elastic film can bulge towards the negative pressure suction cavity, and has different bulging degrees under different sizes of negative pressure. The application has good biocompatibility, can simulate the continuous change of a tumor, and has consistency with the intracranial aneurysm in the body in terms of hemodynamic characteristics.

The utility model relates to the technical field of arterial aneurysm embolism instrument conveying, in particular to an implant conveying system which comprises a pushing tube with a tube cavity; one end of the conveying piece is connected with one end of the pushing pipe through a connecting spring; the conveying piece is provided with a conveying cavity and a positioning hole communicated with the conveying cavity; one end of the releasing wire sequentially penetrates through the pipe cavity, the inner space of the connecting spring and the conveying cavity into the positioning hole, and the other end of the releasing wire is arranged at the other end of the pushing pipe through a fixator; when the implant is conveyed, the tail ring of the implant is arranged in the conveying cavity, and one end of the release wire sequentially penetrates through the pipe cavity, the inner space of the connecting spring, the conveying cavity and the tail ring to enter the positioning hole; and the end, located in the positioning hole, of the release wire is pulled out through the fixator, so that the implant is released. The tail ring of the implant is limited by arranging the release wire in the positioning hole, so that the implant is convenient to convey. Not only is the operation of the implant in the releasing process simplified, but also the releasing stability is improved.

The invention discloses an aneurysm virtual stent implantation simulation method based on a spring analogy method. The method comprises the following steps: reconstructing a three-dimensional model of a preoperative tumor-carrying main blood vessel and a mother blood vessel after aneurysm reduction based on clinical imaging data; extracting a first blood vessel center line, and constructing a virtual stent initialization model; expanding the virtual stent initialization model through a spring analogy virtual stent rapid algorithm, and determining a three-dimensional model of the virtual stent after being expanded in the individualized blood vessel; and calculating curative effect evaluation parameters through a rapid algorithm based on the porosity of the tumor neck cambered surface of the virtual stent. According to the method, the real movement form of stent unfolding can be simulated, the simulation calculation time and the curative effect evaluation duration of the stent unfolding in the blood vessel can be shortened in a large scale, and real-time guidance in the aneurysm virtual intervention process is achieved.

A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.

The present invention compromises a cerebral aneurysm device designed for insertion in various cerebral aneurysm types and block blood flow into a cerebral aneurysm to prevent it from rupturing.

A device (1) is provided for the treatment of aortic pathologies in the abdominal and thoracoabdominal aortic tract comprising a prosthesis (2) including an inlet duct (20) adapted to be sutured to a main blood vessel (V1) at an aneurysm and including a plurality of openings (20a) placed peripherally to the inlet duct (20), a pair of outlet ducts (21) formed by the bifurcation of the inlet duct (20) and each adapted to be sutured to a secondary blood vessel (V2), a plurality of secondary duct (22) each in fluid passage connection with the inlet duct (20) through a respective opening (20a) and each adapted to be sutured to an arterial branch (V3); and a plurality of radiopaque markers (3) each bound to a respective secondary duct (22) at the opening (20a).

The invention relates to an internal fixation type blood vessel puncture plugging device which comprises an internal fixation type patch, the internal fixation type patch comprises a plugging sheet, reinforcing ribs and supporting feet, the reinforcing ribs are evenly distributed on the lower surface of the plugging sheet, and the supporting feet are arranged at the two ends of the lower surface of the plugging sheet respectively. The intravascular fixed patch is made of a degradable shape memory material. Compared with an adhesion type patch, plugging is firmer, wrinkles formed on the blood vessel wall after suturing can be avoided, and the forming risk of thrombus and aneurysm is reduced; the intravascular fixed patch is used for blocking the inner wall of a blood vessel, and the effect is better; by adopting the degradable intravascular fixed patch, rejection reaction can be avoided; the intravascular fixed patch is suitable for blocking a large-diameter puncture opening of a vein or an artery.

The present invention provides a blood vessel segmentation method, device and storage medium, including: obtaining aneurysm image data through 3D-CTA scanning, extracting the blood vessel network in the aneurysm image, and optimizing the blood vessel network; reconstructing a polygonal blood vessel grid based on the aneurysm image data, determining the aneurysm orifice and the center line of the adjacent blood vessel that separate the aneurysm sac and the adjacent blood vessel; analyzing and processing the adjacent blood vessels, obtaining a transition area that separates the proximal blood vessel area from the distal blood vessel area, and obtaining an axial plane; calculating the axial plane so that the direction of the axial plane is at a minimum distance from the center point of the orifice contour and the adjacent blood vessel transition area; and obtaining a blood vessel segmentation image after blood vessel segmentation based on the calculation result of the axial plane. The adjacent blood vessels are decomposed into proximal blood vessel areas and distal blood vessel areas, and other geometric description values ​​are introduced, so that the blood vessels can be better distinguished for the flow field segments related to the function, so that the blood vessel segmentation is more accurate.

The invention discloses a method for tracking a center line of a blood vessel and a related product, and the method comprises the steps: taking a starting point of the blood vessel contained in target angiography data as a center point, and intercepting an image block with a preset size; inputting the image blocks into a trained blood vessel center line tracking model for center line tracking so as to output a next center point of the center point; taking the next central point as a new central point, and intercepting a new image block with a preset size; on the basis of the new image block, inputting the image block into the trained blood vessel center line tracking model for center line tracking, and continuing to execute at the next center point of the output center point until no new center point is output; and determining a center line of the blood vessel based on all the center points. By means of the scheme, the influence of large aneurysm on blood vessel center line extraction can be avoided, and the precision of blood vessel center line tracking is improved.

The present invention relates to the field of image analysis technology, and in particular to a method for reconstructing intracranial and extracranial blood vessels accompanying cerebral aneurysm surgery, the method comprising: obtaining a target three-dimensional image corresponding to the intracranial and extracranial blood vessels accompanying cerebral aneurysm surgery, and identifying each target blood vessel in each slice in the target three-dimensional image; performing a thickness analysis on each target blood vessel; determining a local difference index corresponding to each target blood vessel; determining a grayscale prominence corresponding to each pixel point in each target blood vessel; determining a grayscale change difference corresponding to each target blood vessel; and performing MIP reconstruction according to the local complex index and grayscale change difference corresponding to all target blood vessels in all slices, and the grayscale values ​​corresponding to all pixels therein. The present invention quantifies the local complex index and grayscale change difference of the target blood vessel by analyzing the target three-dimensional image, thereby realizing blood vessel reconstruction through MIP reconstruction and improving the effect of blood vessel reconstruction.

The invention relates to an intravascular device and a method of treating an aneurysm of an intracranial vessel. An intravascular device for positioning in a lumen of an intracranial vessel to transfer blood flow from an aneurysm of the intracranial vessel includes an elastically deformable tubular body including a braid having (1) at least 38 interlaced bioabsorbable polymeric fibers and (2) 2 to 12 elastically deformable interlaced metal wires, where when in an expanded configuration, the fibers are interlaced with one another, and when in an expanded configuration, the fibers are interlaced with one another. The porosity of the braid ranges from 60% to 80%, and the expanded configuration is selected to allow a small amount of blood to enter the aneurysm at a low speed, which results in thrombosis and occlusion of the aneurysm and heals the aneurysm. And wherein the elastically deformable metal wires (1) are each configured to promote and / or maintain radial and / or axial expansion of the polymeric fibers in the tubular body in the lumen, and (2) comprise a radiopaque material configured to promote imaging.

The present invention compromises a cerebral aneurysm device designed for insertion in various cerebral aneurysm types and block blood flow into a cerebral aneurysm to prevent it from rupturing.

The invention discloses a preparation method of a high-transparency elastic cerebral aneurysm model, and the method specifically comprises the following steps: S1, manufacturing a blood vessel model structure: selecting a transparent circular tube structure with a proper shape and size as a blood vessel structure, cutting an arc-shaped incision at a proper position of the middle part of the tube, the method comprises the following steps: S1, preparing an arc-shaped incision, and preparing an aneurysm spherical model of which the diameter is matched with the length of the arc-shaped incision, S2, preparing a container model, S3, installing a blood vessel model structure, S4, filling a filler, and S5, sealing and installing. The invention relates to the technical field of experimental models. According to the preparation method of the high-transparency elastic cerebral aneurysm model, the vasodilatation condition can be analyzed according to the actual simulated blood pressure condition while demonstration can be realized, the purposes of convenient demonstration and more comprehensive expression of the vascular elastic change condition can be well achieved, the functions of the cerebral aneurysm model are greatly enriched, and the development of the cerebral aneurysm model is facilitated. Therefore, experimental research on cerebral aneurysm is greatly facilitated.

Provided is a stent with which the complete recovery of a cerebral aneurysm can be accelerated. One aspect of the present invention is a stent 20 that is placed so as to be compression-bonded to a blood vessel wall and straddle a cerebral aneurysm 21, and has the function of promoting endothelialization prior to the complete occlusion of the cerebral aneurysm in a state of being compression-bonded to the blood vessel wall. This stent 20 is composed of a cylindrical braided body braided with a wire rod. The wire rod is obtained by coating the surface of an element wire, the element wire contains a magnesium alloy containing at least 90 at% of Mg, or pure magnesium, and the function is to promote neointimal formation on the neck of the cerebral aneurysm.

A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.