80 results about "Arterial aneurysm" patented technology

An implantable closure structure is delivered using minimally invasive techniques, and inhibits the migration of liquid and particulate matter from inside a physiological cavity or opening, such as an aneurysm or a septal defect, as well as inhibiting the flow of liquid and particulate matter, such as from an associated blood vessel or chamber, into the physiological cavity or opening. The device has a closure structure that covers the neck or opening of a cavity and has one or more anchoring structures for supporting and retaining the closure structure in place across the cavity or opening.

Described herein are flexible implantable devices or stents that can, for example, navigate tortuous vessels of the neurovasculature. The devices can also conform to the shape of tortuous vessels of the vasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Methods and structures are provided for adjusting, along a length of the device, the porosity of the device while maintaining a cross-sectional dimension. In some embodiments, a distal stent cover covers the distal end of the device and reduces friction between the stent and an inner surface of a delivery device, such as a catheter.

An apparatus and method for stabilization of aneurysm is disclosed. The apparatus comprises an ultraviolet radiation generator for generating UV radiation having a wavelength, strongly absorbed by the DNA and a catheter including means for delivering the ultraviolet radiation to the aneurysm. The distal end of the catheter is placed inside the aneurysm. Stabilization of the aneurysm is achieved by forming a mural arterial thrombus inside the aneurysm. To make irradiation possible, the blood is displaced from the aneurysm by a steady stream of UV radiation transparent fluid. The injury to the endothelium that triggers the thrombus formation is caused by UV radiation delivered to the aneurysm. In several days after intervention the thrombus becomes fully organized, leaving on the inside surface of the aneurysm a thick layer of fibrotic tissue that stabilizes the aneurysm.

The invention discloses an in vitro bionic cycle test system for simulating flowing of blood in arterial aneurysm of a human body under different heartbeat frequencies, relating to the field of biomedicine research on arterial aneurysm and being suitable for carrying out cycle simulating testing on the flowing condition of the blood in the arterial aneurysm of the human body under different heartbeat frequencies. The in vitro bionic cycle test system comprises an upper liquid storage box, a peristaltic pump, a laminar flow generator, an experimental section model, a flow meter, a lower liquid storage box, a cycle pump and a valve. The whole in vitro bionic cycle test system is communicated by a silicon rubber hose and a common rubber hose, fluid is controlled by the valve to flow or stop flowing; the silicon rubber hose is connected to the upper liquid storage box and is downwards connected with the laminar flow generator through the peristaltic pump, a pump head of the peristaltic pump is used for carrying out peristaltic extrusion on the silicon rubber hose; and the laminar flow generator is formed by banding a thin tube embedded in the common rubber hose. Fluid flows out of the laminar flow generator, enters the experimental section model through the common rubber hose, flows into the lower liquid storage box through the flow meter, and returns to the upper liquid storage box through the cycle pump, so that the whole cycle flowing process is completed.

The invention relates to a microcatheter moulding stent used for the intracranial aneurysm embolization and a preparation method of the microcatheter moulding stent. The microcatheter moulding stent comprises a first bending part and a second bending part, wherein the first bending part is connected with the second bending part, the length of the first bending part is 3-5 mm, the length of the second bending part is 5-15 mm, the diameter of the stent is 1-1.5 mm, the length of the stent is 30-50 mm, and the first bending part and the second bending part are used for closely fitting the intracranial vascular bending and arterial aneurysm positions. According to the microcatheter moulding stent and the preparation method, the bending degree of the stent closely fits the intracranial vascular bending and arterial aneurysm shapes, so that the accurate moulding of the microcatheter is guided, therefore, the accurate placement of the microcatheter in the surgery is facilitated, and further, the operative problems including the difficulty in placement of the microcatheter, the separation of the microcatheter, the floating of a spring ring, and the like caused by poor moulding of the microcatheter in the embolism process are avoided.

An occlusion device suitable for endovasculature treatment of an aneurysm in a blood vessel in a patient, including a substantially tubular structure having a proximal end region and a distal end region, having a first, expanded condition and a second, collapsed condition. The device has dimensions in the second, collapsed condition suitable for insertion through vasculature of the patient and through a neck of the aneurysm. The device further includes a control ring having a substantially annular body disposed on the proximal end region of the structure and at least substantially circumscribing the proximal end region to prevent radial expansion of the proximal end region and to provide an engagement feature during manipulation of the occlusion device.

Described are various embodiments of an improved endoprosthesis that includes at least one tubular graft section coupled to additional tubular graft sections which are then coupled to a tubular bifurcated main section. Various embodiments described and shown herein allow for a health care provider to design and select an appropriate AAA implant for AAA presentations other than an infrarenal AAA. The implants can also be utilized for other arterial aneurysms.

A filming support comprises a supporting structure and a film covering the supporting structure, wherein the film is composed of at least two stacked layers of allogeneic acellular tissue base film, the smooth side of each layer of the base film faces the supporting structure while the rough side faces out; the adjacent two layers of base film are arranged by crossing at a certain angle along a growth direction of a collagen bundle. In the at least two layers of the allogeneic acellular tissue base film, all base film is provided with a plurality of through holes expect for the innermost layer, and the hole diameter increases gradually from the inner layer to the outer layer. The use of the filming support is effective in reducing the formation of thrombus and endotheliosis, in enhancing film strength and reducing the axial tension of the film during the release of the filming support, and in adhering endothelial cells to promote cell differentiation to promote the ingrowth of tissues and vessels, and quickening the endothelialization of lesion areas of arterial aneurysm to give better effect in treating arterial aneurysm.

The invention relates to a stent model matching method and device for intracranial aneurysm and a stent simulation display method. The stent model matching method comprises the following steps of: acquiring image data related to intracranial artery blood vessels, and constructing a three-dimensional blood vessel model by processing the image data; obtaining a target area in the three-dimensional blood vessel model, and extracting a blood vessel center line in the target area and a plurality of pieces of center line data of points on the blood vessel center line; carrying out processing according to the blood vessel center line and the center line data to obtain a nominal diameter and a nominal length of the stent; and according to the nominal diameter and the nominal length of the stent, obtaining a matched stent model in a preset stent database. By adopting the method, the stent model matching efficiency and the blood vessel suitability can be improved.

The invention discloses a DNA library for detecting pathogenic genes of multiple genetic vascular diseases through a targeted high-throughput semiconductor sequencing technology and application thereof. The operating method specifically comprises the following steps: designing a primer pool according to 151 pathogenic genes of genetic vascular diseases, performing super-multiple PCR amplification on genomic DNA of samples, sequencing the amplification products by utilizing the high-throughput semiconductor sequencing technology, searching pathogenic mutations, and providing genetic and molecular biological theoretical basis for clinical diagnosis. The DNA library disclosed by the invention has the characteristics of accuracy, rapidness, flexibility and low cost, the 151 gene detection areas involved in the invention are capable of detecting multiple genetic vascular diseases such as aortic dissection, arterial aneurysm, hemorrhagic apoplexy and the like, and the DNA library has great significance and clinical values on diagnosis and differential diagnosis of the genetic vascular diseases.

The invention discloses a plugging device used in a tubular cavity. The plugging device is characterized by comprising a plugging end (1), a transition section (2) and an open end (3), wherein the plugging end (1) is used for plugging a neoplasia neck port in the tubular cavity, and the transition section (2) is connected with the plugging end (1) and the open end (3) and is located in the blood vessel cavity. After the plugging device used in the tubular cavity is implanted in the blood vessel, the plugging device can be stably arranged at the crotch of the blood vessels or the tail section of the corresponding blood vessel, is used for plugging the neoplasia neck port in the cavity, can directly plug an ending arterial aneurysm neck port and can also assist embolization of a spring ring of the ending wide-necked arterial aneurysm neck port after being put in.

The invention relates to a novel intracranial aneurysm plugging device and a manufacturing method thereof. The plugging device comprises a plugging device body, developing marks, a conveying guide wire, a separation point, a conveying tube and a separator. The developing marks are fixed to the far end and the near end of the plugging device body respectively. The plugging device body is in a net shape woven by 24-72 strands of nickel-titanium memory alloy wires. After the plugging device is completed expanded, the developing marks are arranged at the far end and the near end respectively, andthe nickel-titanium memory alloy wires at the far end and the near end of the plugging device body are bundled and fixed through the developing marks respectively. The conveying guide wire is locatedin the conveying tube. The separation point is arranged between the developing mark at the near end of the plugging device body and the far end of the conveying guide wire. The near end of the conveying guide wire is connected with the separator. According to the manufacturing method of the plugging device, shaping is carried out through a plugging device mold. Under the is condition of not opening the skull, for large arterial aneurysm with the upper portion narrower than the lower portion and forky arterial aneurysm, the plugging device body is implanted, the plugging device is stable in structure, a tumor cavity can be fast and densely filled after the plugging device is expanded, and therefore flowing of blood in an arterial aneurysm cavity is retarded, the impact pressure of the bloodon the tumor cavity is reduced, the restoration capacity is enhanced, and the aim of treating the arterial aneurysm is achieved.

The invention discloses a film-covered woven body system for embolic arterial aneurysms in the field of medical appliances. The film-covered woven body system comprises a meshed woven body and a delivery system connected with the woven body, the woven body is of a gourd-shaped double-layer spherical structure after being released, the bottom of the woven body is flat, and a connection part of the woven body and the delivery system is arranged inside the woven body, that is, the connection part is arranged not to protrude out of the woven body. The inner surface or the outer surface of the woven body is covered by a film. The film is made of polytetrafluoroethylene and the like and is arranged in one layer or a plurality of layers. Complete film coverage or partial film coverage can be adopted, but the bottom of the woven body needs be fully covered by the film. Compared with a woven body with no covering film, blood can be prevented more effectively from entering the arterial aneurysm to cause impact on the aneurysm wall. Effects can be improved along with increase of the number of film layers. Meanwhile, since the inner side of the woven body is covered by the film, meshes of the surface of the woven body can be made relatively sparse, the number of woven yarns for the woven body can be decreased, the size of the external contour can be reduced, and resistance in in-vivo delivery can also be reduced.

The invention discloses an intravascular prosthesis. Particularly, the prosthesis comprises i layers of tubular intravascular stents, wherein 2<=i<=8, and the prosthesis is used for treating aortic dissection and arterial aneurysm lesion, particularly ascending aortic aneurysm; the tubular intravascular stents are divided into dense mesh weaved stents and sparse mesh weaved stents, the dense meshweaved stents are large in mesh density, and the sparse mesh weaved stents are small in mesh density; the quantity of the dense mesh weaved stents is m, wherein 1<=m<=4; the quantity of the sparse mesh weaved stents is n, wherein 1<=n<=4, and i=m+n; the dense mesh weaved stents and the sparse mesh weaved stents are coaxially stacked together in the circumferential direction, are used for cooperatively supporting the blood vessel and mutually limit axial stretching or shortening deformation of the stents. By means of the prosthesis in the blood vessel, through a stent interventional operation,the aortic dissection can be effectively treated, particularly the aortic dissection or arterial aneurysm incapable of being subjected to interventional treatment by current clinical medicine.

Described herein are flexible implantable devices or stents that can, for example, navigate tortuous vessels of the neurovasculature. The devices can also conform to the shape of tortuous vessels of the vasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Methods and structures are provided for adjusting, along a length of the device, the porosity of the device while maintaining a cross-sectional dimension. In some embodiments, a distal stent cover covers the distal end of the device and reduces friction between the stent and an inner surface of a delivery device, such as a catheter.

The embodiment of the invention discloses an aneurysm rupture risk assessment method and system, and the method comprises the steps: obtaining to-be-processed data which comprises first data and / or second data; inputting the to-be-processed data into an aneurysm risk assessment model to obtain an aneurysm risk assessment result of the to-be-processed data, wherein the aneurysm risk assessment model is a model obtained in advance based on machine learning, and the aneurysm rupture risk assessment result comprises an aneurysm rupture probability and / or an important characteristic factor; and outputting an aneurysm risk assessment result of the to-be-processed data. According to the arterial aneurysm rupture risk assessment method and system, the participation of human factors can be eliminated or reduced, the consumed time is shortened, the arterial aneurysm rupture risk assessment can be simply and rapidly carried out, and the objective support is provided for arterial aneurysm rupturerisk assessment.

The invention discloses an intracranial dense mesh stent with an anticoagulant coating. The intracranial dense mesh stent comprises a dense mesh stent body and a hydrophilic polymer material covering the dense mesh stent body, wherein the dense mesh stent body is coated with the anticoagulant coating. According to the intracranial dense net stent, not only can a channel be reconstructed for blood vessels, but also antithrombotic treatment can be carried out on the blood vessel wall at the position of stent implantation, and embolism treatment can be carried out on aneurysm at the same time.

The embodiment of the invention discloses a prediction method and device for intracranial aneurysm operation planning and equipment , and belongs to the technical field of medical images and computers. The method comprises the following steps: performing three-dimensional reconstruction based on to-be-processed craniocerebral image data to obtain a reconstructed blood vessel image; based on the reconstructed blood vessel image, adopting a binary tree method to obtain a tree structure of a blood vessel center line network; and based on the aneurysm parameter and the parent artery parameter of the to-be-processed craniocerebral image data and the tree structure of the blood vessel center line network, obtaining the stent model of a stent for intervention and the release position of the stent for intervention. By adopting the method provided by the embodiment of the invention, the model selection of a stent for intervention can be automatically realized, the release position of a stent for intervention can be automatically determined, and reference is provided for clinical application.

The invention discloses a film-covered woven body system for embolic arterial aneurysms in the field of medical appliances. The film-covered woven body system comprises a meshed woven body and a delivery system connected with the woven body, the woven body is of a gourd-shaped double-layer spherical structure after being released, the bottom of the woven body is flat, and a connection part of the woven body and the delivery system is arranged inside the woven body, that is, the connection part is arranged not to protrude out of the woven body. The inner surface or the outer surface of the woven body is covered by a film. The film is made of polytetrafluoroethylene and the like and is arranged in one layer or a plurality of layers. Complete film coverage or partial film coverage can be adopted, but the bottom of the woven body needs be fully covered by the film. Compared with a woven body with no covering film, blood can be prevented more effectively from entering the arterial aneurysm to cause impact on the aneurysm wall. Effects can be improved along with increase of the number of film layers. Meanwhile, since the inner side of the woven body is covered by the film, meshes of the surface of the woven body can be made relatively sparse, the number of woven yarns for the woven body can be decreased, the size of the external contour can be reduced, and resistance in in-vivo delivery can also be reduced.

The present invention relates to the new use of alpha-ketoglutarate, amides, and salts and mixtures thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the in vivo therapeutic improvement of blood vessel elasticity, in particular arterial elasticity in a subject in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and / or prophylaxis of hypertension, pulmonary arterial hypertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension.

The invention discloses an oligopeptide ATR001 and a monoclonal antibody prepared through the oligopeptide and having bias AT1R regulating function and application. The oligopeptide ATR001 is characterized in that the amino acid sequence is AFHYESQ, the hybridoma cell is CQ8-A2D9; and the storage number is CCTCC NO: C2017108. According to the oligopeptide ATR001, the monoclonal antibody technologyis carried out to prepare the AT1R monoclonal antibody, and the antibody is capable of regulating the AT1R function in a bias manner and is capable of treating vascular remodeling diseases such as high blood pressure, atherosclerosis and arterial aneurysm.

The invention provides a covered stent and a making method thereof. The covered stent comprises a stent body and a covering membrane attached outside the stent body, thus, the covered stent can have a smaller appearance, and therefore the flexibility of the covered stent is improved; in addition, the surface of the stent body is not completely covered with the covering membrane, and therefore the covered stent does not block branch vessels. Furthermore, the covering membrane is made of biodegradable polymer materials, therefore, endothelialization of the covered stent can be promoted, arterial aneurysm is activated to shrink, formation of thrombus in the covered stent is avoided, blocking of the branch vessels is avoided, and blood flow reserve of a patient is increased. Further, the making method of the covered stent is simple, the covered stent can be made before an operation according to different clinic requirements, therefore, the covered stent can better adapt to the condition of the patient, and the product preparation cost of a hospital is reduced.

The embodiment of the invention discloses an aneurysm rupture risk assessment method and system. The method comprises the steps: converting a to-be-processed three-dimensional DSA image into an imagein an STL format, and measuring an aneurysm morphological parameter of an observed person as first data; acquiring medical record information parameters of the observed person corresponding to the to-be-processed three-dimensional DSA image as second data; inputting the first data and / or the second data into an aneurysm risk assessment model to obtain an aneurysm risk assessment result of the to-be-processed three-dimensional DSA image, wherein the aneurysm risk assessment model is a model obtained by pre-training based on a support vector machine algorithm; and outputting the aneurysm risk assessment result of the to-be-processed three-dimensional DSA image. According to the arterial aneurysm rupture risk assessment method and system, participation of human factors can be eliminated or reduced, consumed time is shortened, arterial aneurysm rupture risk assessment can be simply and rapidly carried out, and an objective basis is provided for arterial aneurysm rupture risk assessment.

An occlusion device suitable for endovascular treatment of an aneurysm in a blood vessel in a patient, including a substantially tubular structure having a proximal end region and a distal end region, having a first, expanded condition and a second, collapsed condition. The device has dimensions in the second, collapsed condition suitable for insertion through vasculature of the patient and through a neck of the aneurysm. The device further includes a control ring having a substantially annular body disposed on the proximal end region of the structure and at least substantially circumscribing the proximal end region to prevent radial expansion of the proximal end region and to provide an engagement feature during manipulation of the occlusion device.

The invention provides an aneurysm rupture state prediction method and device. The method comprises the steps of: receiving original sample data; preprocessing the original sample data to obtain processed data, and establishing a training set model; and training the machine learning model of each aneurysm rupture state by using the training set model to obtain the prediction result of the aneurysmrupture state. According to the aneurysm rupture state prediction method and device, the method for jointly predict the arterial aneurysm rupture by combining clinical information, morphological information and hemodynamic information can better utilize the known data and is more accurate in prediction result compared to a traditional method.

The invention discloses a multi-point electrolytic detachment system and method for detaching embolism materials. The system comprises a spring ring and a spring ring conveying system. The spring ring comprises a plurality of end-to-end small spring rings and detachment points for connecting the small spring rings. The spring ring conveying system comprises a conveying guide wire and a micro catheter. The conveying guide wire is arranged inside the micro catheter. The front end of the conveying guide wire is connected with the tail end of the spring ring through the last detachment point, an electrified wire is arranged at the front end of the micro catheter, a micro wire is arranged on the wall of the micro catheter, and the micro wire is connected with the electrified wire. Different detachment points are arranged on the spring ring, detachment is performed at nearby detachment points after arterial aneurysm embolism is satisfied, an existing multi-spring-ring implanting method is replaced, the operation time is shortened, and the operation cost of a patient is lowered.

The invention relates to an arterial aneurysm stent at an intracranial bifurcation. The arterial aneurysm stent comprises a stent body, a blocking part, a connecting rod and developing points, whereinthe sent body is net-shaped, the blocking part is flared, the stent body is connected with the blocking part through the connecting rod, and the developing points are distributed at the tail of the near end of the stent body and the far end of the blocking part. Compared with the prior art, the arterial aneurysm stent at the intracranial bifurcation has the advantages that the closure of an arterial aneurysm at the intracranial bifurcation is better solved, and the effectiveness and safety of the treatment are improved.

The invention relates to a heparin-loaded covered stent for treating arterial aneurysm and a preparation method thereof. The covered stent is characterized in that a covered layer is formed by heparin-loaded emulsion electrostatic spinning nanofibers, wherein the heparin-loaded nanofibers are provided with multi-core-layer structures. The preparation method of the covered stent comprises the following steps of arranging a preparation device, compounding a heparin sodium aqueous solution, preparing heparin sodium aqueous solution-sorbide oleate-dichloromethane emulsion, preparing an electrostatic spinning solution, and preparing a loading heparin covered stent. By adopting the covered stent, the problems which are common in treatment of small vessel diseases such as vascular endothelial proliferation and thrombosis can be effectively avoided; the heparin-loaded covered stent has a wide application prospect in the field of intravascular interventional treatment of small vessels arterial aneurysm; and the preparation method has the advantages that the preparation device is simple, procedure parameters are less, and the preparation process is stable.

The invention discloses a nanometer electro-spinning tectorial membrane etching support and method for curing intracranial aneurysm. The nanometer electro-spinning tectorial membrane etching support comprises a support main body of a cylindrical net structure. Four radio-opaque first mark points are arranged at each of two ends of the support main body and are used for accurate release of the support. Two radio-opaque second mark points used for developing positioning of the support in the release process are arranged at the starting point and the stop point of a tectorial membrane in the middle section of the support main body. The nanometer electro-spinning tectorial membrane etching support further comprises a push device. The push device is arranged at one end of the support main body and comprises a lead wire and a conveying pipe. The lead wire is located in the conveying pipe, and the front end of the lead wire is connected with the support main body. According to the nanometer electro-spinning tectorial membrane etching support and method, intracranial aneurysm haemodynamics changes simply by inserting the support, the aneurysmal neck can be directly blocked to promote thrombus forming and organizing in the arterial aneurysm, accordingly the purpose of rebuilding parent arteries anatomically is achieved, and the parent arteries are kept unblocked.