6 results about "Collagen fiber bundle" patented technology

A process for producing a multifilament collagen fiber bundle involves treating a multifilament support polymer-collagen fiber bundle having a plurality of monofilaments of collagen supported on a support polymer with a series of liquid media having a decreasing concentration of the support polymer to remove the support polymer from the multifilament support polymer-collagen fiber bundle. The support polymer is more soluble than the collagen in the liquid media and the gradual removal of the support polymer provides enough time for collagen molecules to self-assemble into fibrils. The resulting multifilament collagen fiber bundle has a D-band structure similar to natural collagen but shifted by 1 / 6th of the D-band. The multifilament collagen fiber bundle can be crosslinked with ultraviolet light in the absence of photo-initiator to provide a crosslinked collagen product with superior tensile strength and Young's modulus making the product useful in collagen-based biomaterials for tissue repair and regeneration.

This invention discloses a method for preparing acellular dermal matrix, belonging to the field of tissue engineering technology. The preparation method includes: selecting pelts from traceable animals aged one to three months, purifying them through steps such as soaking, fleshing, defatting, hair removal, liming, deliming, and softening in a tanning process to obtain acellular dermal matrix. The acellular dermal matrix obtained by this invention removes antigenic components such as cells, hair follicles, and extracellular proteins during the preparation process, minimizing its immunogenicity while preserving the collagen fiber structure in its extracellular matrix. Simultaneously, the preparation method of this invention moderately loosens the collagen fiber bundles. This process not only effectively alleviates the entanglement between fiber bundles but also successfully increases the exposure of hydrophilic groups, giving the acellular dermal matrix excellent hydrophilicity, which is more conducive to cell proliferation and migration.

The application provides a functionalized repair stent and a preparation method and application thereof. The functionalized repair stent comprises a tubular stent, a fiber membrane covering the tubular stent and physiologically active molecules specifically combined with the surface of the fiber membrane; or the functionalized repair stent comprises a collagen fiber bundle, a fiber membrane covering the collagen fiber bundle and physiologically active molecules specifically combined with the surface of the fiber bundle and the fiber membrane; or the functionalized repair stent comprises a collagen fiber bundle, physiologically active molecules specifically combined with the surface of the collagen fiber bundle and a tubular stent covering the collagen fiber bundle; the tubular stent comprises a tubular structure and a coating covering the tubular structure. In the application, the functionalized repair stent with certain strength and slow-release effect is prepared by designing the structure of the functionalized repair stent, the functionalized repair stent can be prepared semi-mechanically and automatically, the efficiency is high, the functionalized repair stent can be degraded in the body, a secondary operation is not needed and the size and shape are controllable.

The present invention addresses the problem of providing a method for evaluating a sagging / wrinkle state on the basis of a novel mechanism. The present inventors have found that frame-like collagen formed by collagen bundles is present in the dermal layer, and discovered that the frame-like collagen present in the dermal layer maintains skin shape and contributes to anti-sagging and anti-wrinkle of the skin. Therefore, the present disclosure relates to a method for evaluating a sagging / wrinkle state of skin by evaluating the frame-shaped collagen formed by collagen bundles in a target skin.

A method of producing a multifilament collagen fiber bundle involves treating a multifilament support polymer-collagen fiber bundle containing a plurality of collagen monofilaments supported on a support polymer to remove the support polymer from the multifilament support polymer-collagen fiber bundle using a series of liquid media containing a decreasing concentration of the support polymer. The support polymer is more soluble than collagen in a liquid medium, and the gradual removal of the support polymer provides sufficient time for collagen molecules to self-assemble to form fibrils. The resulting multifilament collagen fiber bundle has a D-band structure similar to native collagen, but is offset by 1 / 6 D-band. The multifilament collagen fiber bundle can be cross-linked through ultraviolet rays under the condition of no photoinitiator to form a cross-linked collagen product with excellent tensile strength and Young modulus, and the product is suitable for collagen-based biological materials in the field of tissue repair and regeneration.

The purpose of this disclosure is to find a novel function of an ergothioneine compound, and to provide a preparation using this function.　One embodiment of this disclosure is a composition for suppressing a decrease in the thickness of a collagen fiber bundle due to UVA irradiation, the composition containing an ergothioneine compound as an active ingredient.