43 results about "Collagen fiber bundle" patented technology

The invention discloses spun-laced cloth and a method for manufacturing the spun-laced cloth. The spun-laced cloth is composed of collagen fiber bundles, other textile-used staple fibers and interstitial fibers, wherein the collagen fiber bundles are mutually interpenetrated and interweaved with branches of the collagen fiber bundles to form stereo reticular braided structures, other textile-used staple fibers are located on skeleton of the stereo reticular braided structures, reticular entwining is formed between the textile-used staple fibers mutually or between the textile-used staple fibers and the collagen fiber bundles and the branches of the collagen fiber bundles, and fiber is adhered or bound by the interstitial fibers. The method of the invention can take animal raw hide as raw materials and can be realized through following technical steps: screening the raw materials, dipping, unhairing, degreasing, defibering liquid, tanning, dewatering and drying, mixed liganding, adding the interstitial fibers, health preserving, opening, combing,laying net, spunlacing, and hot rolling, furthermore, the method of the invention can also take the animal leather after tanning as the raw material and can be realized through following steps: screening the raw materials, dipping, defibering the liquid, dewatering and drying, mixed liganding, adding the interstitial fibers, health preserving, opening, combing, laying net, spunlacing, and hot rolling.

The invention discloses a method for preparing collagen/bioglass/hyaluronic acid tissue repairing materials, comprising the following steps: combining I-type collagen and bioglass, static layering, filtering, adjusting pH value, adding hyaluronic acid, cross linking, molding, freezing and drying and the like. In the process of preparing the collagen/bioglass/hyaluronic acid tissue repairing materials, the diameter of the collagenous fiber bundle composing the network structure of the tissue repairing materials is increased by adjusting the ratio of the I-type collagen and bioglass and the pH value of the combined solution, and the microstructure of the materials is adjusted, thus achieving the aim of improving mechanical strength thereof. The collagen/bioglass/hyaluronic acid tissue repairing materials prepared by the invention has improvement in mechanical property and degradation performance, can be widely used in medical field, also can be used in tissue engineering scaffolds and bone defects and soft tissue injuries repairing.

The invention discloses a core spun yarn taking collagenous fibers as a main material and as a leather layer and a processing method of the core spun yarn. The core spun yarn comprises a core yarn, wherein a leather layer formed by collagenous fiber bundles or a collagenous fiber bundle and other textiles covers or cover the core yarn; a collagenous fiber bundle and a branch thereof and an adjacent collagenous fiber bundle and a branch thereof form three-dimensional meshed structures which are mutually staggered, twisted and combined and axially arrayed. The processing method of the core spun yarn taking the collagenous fibers as the main material and as the surface layer comprises the following steps: (1) extracting collagenous fibers; (2) carding and striping the fibers; (3) drawing the fibers; and (4) performing spinning. According to the core spun yarn and the processing method thereof, the problem that the basic tensile strength cannot be achieved by extracting the collagenous fibers from leather and directly spinning the fibers in the prior art is solved, and the shortcoming that fine yarns are very hard to process or cannot be processed and the shortcoming that a product cannot fully exert the characteristic of the collagenous fibers as a large number of other textile fibers must be blended for spinning are overcome.

Isolated composites are disclosed comprising collagen fibers isolated from a Sarcophyton sp. coral. An exemplary composite comprises as a first component a bundle of collagen fibers, the collagen fibers being isolated from a Sarcophyton sp. coral, and a second component selected from the group consisting of a polysaccharide, a polypeptide, polylipid, a synthetic polymer, a metal and a mineral, wherein the bundle of collagen fibers comprise woven fibers, twisted fibers, braided fibers, knitted fibers, tied fibers, or sutured fibers. Uses thereof and method of generating are also disclosed.

A filming support comprises a supporting structure and a film covering the supporting structure, wherein the film is composed of at least two stacked layers of allogeneic acellular tissue base film, the smooth side of each layer of the base film faces the supporting structure while the rough side faces out; the adjacent two layers of base film are arranged by crossing at a certain angle along a growth direction of a collagen bundle. In the at least two layers of the allogeneic acellular tissue base film, all base film is provided with a plurality of through holes expect for the innermost layer, and the hole diameter increases gradually from the inner layer to the outer layer. The use of the filming support is effective in reducing the formation of thrombus and endotheliosis, in enhancing film strength and reducing the axial tension of the film during the release of the filming support, and in adhering endothelial cells to promote cell differentiation to promote the ingrowth of tissues and vessels, and quickening the endothelialization of lesion areas of arterial aneurysm to give better effect in treating arterial aneurysm.

The invention relates to a dyeing process for collagen fiber regenerated leather. The process successively comprises at least two dyeing treatment, at least one fixation treatment, at least one handfeel modification and drying treatment, wherein dyeing, fixation and handfeel modification are all carried out in an supersonic sound field, so a coloring agent, a fixing agent and a handfeel modifier can effectively penetrate into collagen fiber bundles so as to obtain a more uniform dyeing effect. The concentration of the coloring agent in sequentially used bath liquids increasingly decreases, temperatures of the bath liquids gradually increase, the power of the supersonic sound field increasingly decreases, so bath liquids with high concentration can infiltrate into a leather blank at first, and flooding which is serious in the process of filtration can be eliminated in subsequent dipping in liquids with low concentration; thus, flooding generated in subsequent procedures increasingly decreases, and uniform dyeing of the leather blank is realized. Moreover, surface flooding is eliminated in virtue of a brush of a brush roller in the invention. The invention also relates to a dyeing apparatus capable of realizing continuous uniform dyeing of cloth and leather.

The invention discloses a novel fabric and novel leather product in which a collagen fiber bundle forms a network structure. The fabric comprises a bottom yarn woven layer, and further comprises the collagen fiber bundle, the collagen fiber bundle is sleeved with the bottom yarn of the bottom yarn woven layer and protrudes from the surface of the bottom yarn woven layer, the protruding collagen fiber bundle and its branches are interwoven to form the network structure, and portions of the branches of the collagen fiber bundle are sleeved with the bottom yarn so that at least the ends of the portions of the branches protrude from the bottom yarn woven layer. The leather product includes the novel fabric and a leather surface course. The novel fabric and the leather product have good mechanical properties due to the formation of the network structure.

The invention relates to the field of tissue engineering technology, and in particular to a breast repair patch and a preparation method thereof. Problems in the prior that collagen bundles on the surface of a loose layer become free, floating and even falling off are solved; appearance quality of the finished product (the breast repair patch) is improved and service cycle of tissue preservation liquid and preservation cycle of the finished product are prolonged; and meanwhile, the breast repair patch, when used, can facilitate adhesion and fixation of the membrane tissue loose layer, accelerate in-growth and migration of breast cells and tissues, induce generation of new tissues and greatly relieve such symptoms as hard breasts, pain and the like after an operation. According to the embodiment, the breast repair patch provided by the invention comprises a mammal membrane tissue which comprises a dense layer and the loose layer and a collagen coating which is formed on the surface of the loose layer.

The invention discloses an artificial cornea, made by soaking animal decellularized corneal stroma in a photosensitizer first and performing uniform crosslinking in ultraviolet light. A photo-oxidation collagen crosslinking method comprises following steps: (1), soaking animal decellularized corneal stroma in a photosensitizer solution 1-5 mg/ml for 1-60 min; (2), taking the soaked animal decellularized corneal stroma, placing it in a culture vessel, and exposing it to ultraviolet light 100-400 nm in wavelength for 1-60 min; (3), soaking the stroma in a PBS solution for 0.5-4 h, and shaking for 0.5-2 h. The invention has the advantages that the biomechanic characteristics such as mechanical strength of the animal decellularized corneal stroma can be effectively improved; as the biomechanic characteristics are mainly determined by collage fiber, collagen fiber bundles and the composition of their spatial structures, the biomechanic properties and stability of the animal decellularized corneal stroma can be improved through photo-radiation/photosensitizer crosslinking.

The invention discloses artificial fur and a preparation method thereof. The fur comprises a leatherboard layer and a fleece layer, and is characterized in that: the leatherboard layer has a three-dimensional netlike weaving structure with a collagenous fiber bundle as a main body; and one end and/or the middle end of the fiber of the fleece layer is entangled on the collagenous fiber bundle of the leatherboard layer and is firmly locked by the collagenous fiber bundle. The preparation method comprises the following steps of: web formation, fiber web superposition, spunlaced consolidation, texturing and raising, and contraction shaping before and after the texturing and raising as required to prepare the artificial fur. The weaving structure, appearance and sanitation performance of the fur are consistent with those of natural fur leatherboard and the fur has higher stretching amplitude and wider application field than those of natural fur; the fiber of the fleece layer is embedded into the leatherboard layer by physical entanglement, and the fur does not contain any adhesive and has the operational performance far higher than that of artificial fur manufactured by flocking through an adhesive; and the artificial fur can be manufactured from various leather scraps and waste animal fur and is more environmental-friendly.

To increase a tissue regeneration ability of a living body such as a collagens production ability of fibroblast in the dermis in a skin defect area typified by a large wrinkle or wound, a flavanone derivative such as farrerol is used as an active ingredient of an external preparation for skin. Further, to efficiently screen a substance having an excellent effect on promoting wound healing, the remodeling action of collagen fiber bundle is tested by using skin wound model.

The invention relates to molding equipment for a collagen fiber bundle used for a hemostatic material, which effectively solves the problem in the prior art that product quality is reduced because fiber is not protected in the processing process. The molding equipment comprises a main body, wherein the lower part of the main body is a rack, a guide wire wheel set and a guide wire roller set are fixed at the upper part of the main body, a cover plate is arranged on the main body in a sliding way, the cover plate covers the upper part of the main body and is made from a transparent material, a fiber inlet is formed in the left side of the cover plate, a fiber outlet is formed in the right side of the cover plate, and a plurality of locking devices connected with the main body are arranged atthe rear side of the cover plate; the molding equipment is reasonable in structure, convenient to use, and is in a sealed environment all the time in the molding process of the collagen fiber bundle,so as to prevent contact with the external substances, and ensure the cleanness of the production environment; furthermore, liquid contained in the collagen fiber is cleared to a certain extent, so that the fiber is finer, and the produced product does not contain impurities and is better in quality.

Disclosed is solubilized collagen fiber ball: that is crimped and does not have fiber separation defects within which the amount of water content and the amount of hydrophilic organic solvent are evenly distributed; and that dissolve instantly and uniformly when used. The fiber ball has a composition that may comprise 66 to 87 wt % solubilized collagen, 2 to 6 wt % buffer salt, 10 to 22 wt % water content, and a trace amount to 6 wt % residual hydrophilic organic solvent, and is 3 to 25 mm in diameter, weighs 3 to 20 mg, has an average fiber size of 3 to 10 dtx, and a length of 1 to 20 cm. The fiber ball, which has a wavy shape and comprises uniform bundles of solubilized collagen fibers formed in a spherical shape, may have a bulk density of 4.0 to 8.0 mg/cm3, and a swab diameter of 3 to 25 mm.

The invention provides a modification method of collagen fiber bundles. The collagen fiber bundles are dipped into aqueous binders and then are dried, carding and opening are carried out, and the collagen fiber bundles can become a novel fiber material capable of being used for non-woven and woven technology.

An optical method for determining collagen bundle orientation in bovine pericardium includes the use of a system having a light source which transmits light through a first polarizer, a tissue for making a prosthetic valve leaflet, and a second polarizer, where the light then illuminates a detector plate. The light that illuminates the detector plate is used to determine the orientation of collagen fiber bundles. The orientation of the collagen fiber bundles is used to determine where to cut the leaflet edges.

The invention provides a comprehensive tanning agent. The comprehensive tanning agent is prepared from the following components in parts by mass: 10-20 parts of THPC (Tetrakis Hydroxymethyl Phosphonium Chloride) tanning agent, 2-3 parts of fatting agent, 70-90 parts of NaCl, 5-10 parts of silicon-aluminium tanning agent and 2000-3000 parts of water. The invention also provides a no-chromium tanning process of the furs. The comprehensive tanning agent provided by the invention has the beneficial effects that the novel comprehensive tanning agent combined with the silicon-aluminium THPC is adopted, the THPC is firstly used for pre-tanning, and new intermolecular bonds are formed in a collagen structure, so that the strength of collagen fiber bundles can be improved, the fiber can be primarily sized and the shrinking temperature can be increased; then the silicon-aluminium tanning agent is used for re-tanning, so that the shrinking temperature of a leather board can be further increased,the insufficient pre-tanning can be supplemented, the plumpness and the fullness of the leather board can be improved and the quality requirements of a finished product for the leather board can be met; due to no adoption of the chromium tanning agent, the condition of existence of chromium liquid on the furs is also avoided; the method is simple and is suitable for application and promotion in industrial large-scale production.

The invention relates to a collagen fiber quality judgment method, and belongs to the technical field of collagen detection. The method comprises the following steps of: (1) taking treated and extracted collagen fibers, performing mixing and kneading, carrying out moisture detection, then conducting calculating according to a moisture detection result, supplementing ice water into a collagen fibercluster, and uniformly mixing and kneading the substances; (2) carrying out centrifugal treatment on the collagen fiber cluster; taking out the product and measuring moisture at the upper end and thelower end, and if moisture has no difference, indicating that the fiber water absorption capacity is strong; if the lower moisture is higher than the upper moisture, indicating that the water absorption capacity is weak; and (3) detecting the surface viscosity of the collagen fiber cluster: detecting the surface viscosity of the fiber cluster, and under the condition of the same moisture, the smaller the viscosity is, the better the moisture is bound by the fibers, and the better the opening degree of the collagen fiber bundle is; if collagen fibers are damaged, the water absorption capacitybecomes poor, and the surface viscosity is high. The method is scientific, reasonable, easy and convenient to operate and low in cost, and can better guide production by rapidly judging the quality ofthe collagen fibers.

The invention relates to a biological repair mesh and a preparation method and application thereof. The preparation method of the biological repair mesh comprises the following steps of: slicing animal tendon tissues along the axial direction of fibers, then carrying out repeated freezing and thawing, and after repeated freezing and thawing, carrying out rolling and ageing to obtain a collagenousfiber bundle; carrying out decellularization, removal of DNA, removal of an alpha-Gal antigen an removal of a soluble hybrid protein on the collagenous fiber bundle by adopting chemical reagents to obtain the collagenous fiber bundle subjected to removal of immunogenicity; carrying out freeze-drying on the collagenous fiber bundle subjected to removal of immunogenicity, and then carrying out crosslinking under the vacuum condition and at a temperature of 100 DEG C to 115 DEG C to obtain the cross-linked collagenous fiber bundle; and carrying out rolling and fiber expansion on the cross-linkedcollagenous fiber bundle, and then carrying out weaving to obtain the biological repair mesh. By the preparation method of the biological repair mesh, the biological repair mesh with high immunizationsafety and a good mechanical property can be prepared.