420results about "Animal material" patented technology

This invention is directed to tissue engineered prostheses made from processed tissue matrices derived from native tissues that are biocompatible with the patient or host in which they are implanted. When implanted into a mammalian host, these prostheses can serve as a functioning repair, augmentation, or replacement body part or tissue structure.

Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue.

The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.

A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.

A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.

A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.

A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treating a biological tissue may be utilized as a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method. The aqueous sterilizing solution may be glutaraldehyde of about 0.625 weight percent buffered to a pH of about 7.4.

The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon implementation in vivo.

The invention discloses spun-laced cloth and a method for manufacturing the spun-laced cloth. The spun-laced cloth is composed of collagen fiber bundles, other textile-used staple fibers and interstitial fibers, wherein the collagen fiber bundles are mutually interpenetrated and interweaved with branches of the collagen fiber bundles to form stereo reticular braided structures, other textile-used staple fibers are located on skeleton of the stereo reticular braided structures, reticular entwining is formed between the textile-used staple fibers mutually or between the textile-used staple fibers and the collagen fiber bundles and the branches of the collagen fiber bundles, and fiber is adhered or bound by the interstitial fibers. The method of the invention can take animal raw hide as raw materials and can be realized through following technical steps: screening the raw materials, dipping, unhairing, degreasing, defibering liquid, tanning, dewatering and drying, mixed liganding, adding the interstitial fibers, health preserving, opening, combing,laying net, spunlacing, and hot rolling, furthermore, the method of the invention can also take the animal leather after tanning as the raw material and can be realized through following steps: screening the raw materials, dipping, defibering the liquid, dewatering and drying, mixed liganding, adding the interstitial fibers, health preserving, opening, combing, laying net, spunlacing, and hot rolling.

The main theme of the invention is to provide a method for manufacturing industrially, by mechanically comminuting silk yarn, crystalline silk fibroin powder below 3 mum in an average particle diameter, which can be used for various applications. A silk substance such as cocoon filament, silk yarn, or raw silk is brought into an alkali aqueous solution under a pressure of 1 through 5 atmospheric pressure at temperatures from 100° C. through 150° C. to reduce the tensile strength of the silk substance to around 0.02 g/d or less. Thereafter, the resultant silk substance is subjected to dealkalization and drying. Subsequently, the resultant dried silk substance is comminuted into powder below 3 mum in an average particle diameter. Thus, the crystalline silk fibroin powder below 3 mum in an average particle diameter is manufactured.

A spray fill device for delivering water to a washing machine is provided. The spray fill device includes a body defining an inlet, an outlet port, a mounting port, and a plurality of outlet apertures in flow communication with the inlet. The spray fill device also includes a first valve coupled to the inlet, the valve configured to control a flow rate of water into the inlet. The spray fill device also includes a pressure relief mechanism coupled to the mounting port, the pressure relief mechanism inhibiting flow through the outlet port when a pressure within the body is less than a predetermined pressure.

The invnetion relates to a spinning fiber rod comprised of 5-100% collagen fiber and residual textile fiber. Wherein, the process method comprises: screening material, dipping, defibering, degreasing, cleaning, dewatering, drying, opening to remove impurity, mixing, carding, and drafting. This invention can obtain material from wide source, has well applicability, high tensile strength, well moisture/oil absorption properties, and fit to spread in textile industry.

The invention relates to a silk nanofiber manufacturing method, and belongs to the technical field of nano material manufacturing. The manufacturing method includes the steps that silk obtained after degumming treatment is transferred to a solution composed of an inorganic salt or weak acid or weak alkali small molecule compound, deionized water and alcohols, after binding force between nano fibrils in the silk is weakened through soaking, the silk solution is transferred to a high-voltage cell crushing machine or an emulsification machine or a pulp refiner or a crushing machine of a high-speed stirring device, and the soaked silk is mechanically crushed to obtain silk nanofibers. A silk nanofiber solution obtained through the method is similar to the shape of hydrogel, the silk nanofibers are obtained through centrifuging or filtering separation, manufacturing time is short, equipment is simple, operation influence factors are few, and control is convenient. The adopted small molecule compound avoids influences of strong acid or strong alkali on the silk nano fibrils, and the crushing machine can be used for quickly manufacturing the silk nanofibers on a large scale.

The invention discloses a method for preparing collagen microfiber based on an imidazole type ionic liquid/dimethyl sulfoxide system. The animal leather is used as a raw material, and an imidazole type ionic liquid/dimethyl sulfoxide mixture is used as a treatment agent. The method comprises the following steps of treating at 90-130 DEG C to obtain a suspension, performing high-speed centrifugation to obtain a precipitate, and cleaning the obtained precipitate and freeze-drying to obtain the collagen microfiber. The collagen microfiber can be applied to the fields such as textile, high-molecular materials and the like. The adopted reagent ionic liquid is non-volatile and can be recycled, and dimethyl sulfoxide is a low-toxicity solvent, therefore, the preparation method is environment-friendly and has a relatively good application prospect.

The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one or more alkaline solutions. Incubation is optionally carried out with one or more debriding agents including inert dry granular or particulate material including for example beads, and the granular phase of an alkaline agent, including for example granular sodium hydroxide. The incubating may be carried out with agitation. In another embodiment, the medullary canal of the bone is subjected to a positive pressure stream of debriding solution under conditions sufficient to loosen the associated soft tissue from the bone at the interface of the soft tissue and bone. In a further embodiment, the debriding solution is provided as a gel.

The invention discloses a production method of natural colorful mulberry silk floss. The traditional common technology is difficult to reserve the natural color of the colorful cocoons, and the color is faded into white in the processing process. The production method disclosed by the invention comprises the following steps of: selecting cocoons and removing impurities from colorful cocoons; permeating with alkaline water; reeling silk from cocoons to remove the pupa; cleaning and dewatering; adding a degumming agent to keep color and refining; removing gum and grease; decontaminating, rinsing and dewatering; adding a spun silk softening agent; regulating the pH value to 4-8; and dewatering and drying to obtain the silk floss. The method has the advantage of simple technology, and the produced silk floss has the advantages of colorful appearance, even color and luster, low trash content, soft mouthfeel, good tearing toughness and no peculiar smell and can achieve the standard of producing high-quality mulberry silk floss quilts.

The present invention belongs to the field of silkworm cocoon silk reeling off method in filature, and is one kind of silkworm cocoon degumming and bleaching process. The technological process includes the successive steps of: compounding degumming liquid, soaking silkworm cocoon and steaming with water vapor for 20 min, eliminating liquid, rinsing with clear water, dewatering, compounding bleaching liquid, soaking silkworm cocoon and steaming with water vapor for 40 min, eliminating liquid, rinsing with clear water, dewatering, compounding silk protecting liquid, swinging and washing for 30 min, eliminating liquid and stoving. The silkworm cocoon degumming and bleaching process has greatly shortened degumming time from traditional 24 hr to 20 min, homogeneous bleaching and few silk corrosion, and the silk treated with the silk protecting liquid is bright, smooth and without silkworm cocoon smell.