Method for preparing collagen microfiber by use of ionic liquid mixing solvent

A technology of ionic liquids and mixed solvents, which is applied in the chemical post-treatment of fibers, fiber treatment, animal raw materials, etc., can solve problems such as difficulties, and achieve the effects of high utilization rate, wide range of sources, and simple reaction process

Active Publication Date: 2014-02-05
DALIAN ZHONGHUIDA SCI INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current research mostly stays in the direct preparation of collagen into gelatin, and then compounding, compo...

Method used

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  • Method for preparing collagen microfiber by use of ionic liquid mixing solvent

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The first step is to mix [Emim]Cl with dimethyl sulfoxide ([Emim]Cl concentration 80vol%) to make a treatment reagent.

[0024] Step 2: Add 0.5 g of dried pigskin powder into a reactor equipped with 50 ml of treatment agent, stir mechanically (500 rpm), and treat at 130° C. for 10 hours under nitrogen protection to prepare a suspension containing collagen microfibrils.

[0025] The third step is to centrifuge the suspension at high speed (10000rpm) to obtain a white precipitate. The precipitate was freeze-dried to obtain collagen microfibrils with a yield of about 22wt%. The microfibers are 3 μm in length and 0.5 μm in width.

Embodiment 2

[0027] The first step is to mix [Bmim]Cl with dimethyl sulfoxide ([Bmim]Cl concentration 80vol%) to make a treatment reagent.

[0028] Step 2: Add 0.5 g of dried pigskin powder into a reactor equipped with 50 ml of treatment agent, stir mechanically (500 rpm), and treat at 130° C. for 10 hours under nitrogen protection to prepare a suspension containing collagen microfibrils.

[0029] The third step is to centrifuge the suspension at high speed (10000rpm) to obtain a white precipitate. The precipitate was freeze-dried to obtain collagen microfibrils with a yield of about 27wt%. The microfibrils are 5 μm in length and 1 μm in width.

Embodiment 3

[0031] The first step is to mix [Amim]Cl with dimethyl sulfoxide ([Amim]Cl concentration 80vol%) to make a treatment reagent.

[0032] Step 2: Add 0.5 g of dried pigskin powder into a reactor containing 50 ml of treatment agent, stir mechanically (700 rpm), and treat at 130° C. for 12 hours under nitrogen protection to prepare a suspension containing collagen microfibrils.

[0033] The third step is to centrifuge the suspension at high speed (10000rpm) to obtain a white precipitate. The precipitate was freeze-dried to obtain collagen microfibrils with a yield of about 17wt%. The microfibers are 2 μm in length and 0.3 μm in width.

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Abstract

The invention discloses a method for preparing collagen microfiber based on an imidazole type ionic liquid/dimethyl sulfoxide system. The animal leather is used as a raw material, and an imidazole type ionic liquid/dimethyl sulfoxide mixture is used as a treatment agent. The method comprises the following steps of treating at 90-130 DEG C to obtain a suspension, performing high-speed centrifugation to obtain a precipitate, and cleaning the obtained precipitate and freeze-drying to obtain the collagen microfiber. The collagen microfiber can be applied to the fields such as textile, high-molecular materials and the like. The adopted reagent ionic liquid is non-volatile and can be recycled, and dimethyl sulfoxide is a low-toxicity solvent, therefore, the preparation method is environment-friendly and has a relatively good application prospect.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for preparing collagen microfibers by using animal leather and a solvent method. Background technique [0002] Collagen is the most important water-insoluble fibrin outside the cells. It has a triple helix structure and is the skeleton of the extracellular matrix. It is widely found in animal skin, tendon, cartilage and other connective tissues. As a renewable biomass resource, collagen has biocompatibility and degradability, and has been widely used in the fields of biology, food, medicine and daily chemicals. According to statistics, my country produces more than 1.4 million tons of collagen-rich leather waste every year, causing serious environmental pollution and loss of valuable collagen resources. How to effectively utilize this renewable biomass resource is an urgent issue to be solved. [0003] Since the direction of the collagen triple helix is ​​o...

Claims

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Application Information

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IPC IPC(8): C07K14/78
CPCD01C3/00Y02P20/54Y02P20/582
Inventor 魏立纲马英冲李坤兰马宁宁李慧张倩高明王奥博
Owner DALIAN ZHONGHUIDA SCI INSTR
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